Zobrazeno 1 - 10
of 708
pro vyhledávání: '"R., Sunyaev"'
Autor:
Sung Chun, Sebastian Akle, Athanasios Teodosiadis, Brian E Cade, Heming Wang, Tamar Sofer, Daniel S Evans, Katie L Stone, Sina A Gharib, Sutapa Mukherjee, Lyle J Palmer, David Hillman, Jerome I Rotter, Craig L Hanis, John A Stamatoyannopoulos, Susan Redline, Chris Cotsapas, Shamil R Sunyaev
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010557 (2022)
Genetic association studies of many heritable traits resulting from physiological testing often have modest sample sizes due to the cost and burden of the required phenotyping. This reduces statistical power and limits discovery of multiple genetic a
Externí odkaz:
https://doaj.org/article/bc1959622b014966849522ae2a35201b
Autor:
Noah J Connally, Sumaiya Nazeen, Daniel Lee, Huwenbo Shi, John Stamatoyannopoulos, Sung Chun, Chris Cotsapas, Christopher A Cassa, Shamil R Sunyaev
Publikováno v:
eLife, Vol 11 (2022)
The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes. However, despite the availability of gene expressio
Externí odkaz:
https://doaj.org/article/5682a44ba09742f6bec90dd82c1d645c
Autor:
Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta, Andrey A. Mironov, Shamil R. Sunyaev, Alexander A. Gimelbrant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Allele-specific expression in diploid organisms can be quantified by RNA-seq and it is common practice to rely on a single library. Here, the authors show that the standard approach has variable error rate and present Qllelic as a tool to improve rep
Externí odkaz:
https://doaj.org/article/6708d342cd5e4c4980bf8799bffb923c
Shared associations identify causal relationships between gene expression and immune cell phenotypes
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, t
Externí odkaz:
https://doaj.org/article/b68e66cfdaa94729aa5b3c126fb5926d
Autor:
Huwenbo Shi, Steven Gazal, Masahiro Kanai, Evan M. Koch, Armin P. Schoech, Katherine M. Siewert, Samuel S. Kim, Yang Luo, Tiffany Amariuta, Hailiang Huang, Yukinori Okada, Soumya Raychaudhuri, Shamil R. Sunyaev, Alkes L. Price
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by
Externí odkaz:
https://doaj.org/article/2dfa2cb15c014c84868e29d583709f8c
Autor:
Evan M. Koch, Shamil R. Sunyaev
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Numerous studies have found evidence that GWAS loci experience negative selection, which increases in intensity with the effect size of identified variants. However, there is also accumulating evidence that this selection is not entirely mediated by
Externí odkaz:
https://doaj.org/article/3c50ac8de3484bfab77b15b9934cc6ab
An unresolved X-ray glow (at energies above a few kiloelectronvolts) was discovered about 25 years ago and found to be coincident with the Galactic disk -the Galactic ridge X-ray emission. This emission has a spectrum characteristic of a 1e8 K optica
Externí odkaz:
http://arxiv.org/abs/0904.4649
Autor:
Armin P. Schoech, Daniel M. Jordan, Po-Ru Loh, Steven Gazal, Luke J. O’Connor, Daniel J. Balick, Pier F. Palamara, Hilary K. Finucane, Shamil R. Sunyaev, Alkes L. Price
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic
Externí odkaz:
https://doaj.org/article/feb2ef5b1d054956892103cae50e6b53
Autor:
R. J. McGinty, S. R. Sunyaev
Publikováno v:
Nat Struct Mol Biol
Non-B DNA structures formed by repetitive sequence motifs are known instigators of mutagenesis in experimental systems. Analyzing this phenomenon computationally in the human genome requires careful disentangling of intrinsic confounding factors, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661296e70bda256c1248ba3b70102ca9
https://doi.org/10.1038/s41594-023-00936-6
https://doi.org/10.1038/s41594-023-00936-6
Autor:
Corneliu A. Bodea, Adele A. Mitchell, Alex Bloemendal, Aaron G. Day-Williams, Heiko Runz, Shamil R. Sunyaev
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Functional characterization of the noncoding genome is essential for biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts
Externí odkaz:
https://doaj.org/article/01dfcfcedd2d4a578c8bac8e1ec8674c