Zobrazeno 1 - 10
of 385
pro vyhledávání: '"R., D'Alessio"'
Autor:
Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes
Externí odkaz:
https://doaj.org/article/aa0e19b78c824561aa71c9c28ac4ee3b
Autor:
A. Bassi de Toni, G. Culicchia, A. Del Casale, M. Tinè, A. V. Vallerga, L. Cutillo, S. Bernardi, I. Bilotta, A. Fattorini, R. D’Alessio, D. De Felici, M. Pompili, G. Angeletti
Publikováno v:
European Psychiatry, Vol 67, Pp S159-S159 (2024)
Introduction Peripartum mental disorders (PPMD) are characterized by heterogeneous psychopathological symptoms related to specific personality traits, which are only taken into account by a few preventive and therapeutic strategies. Traumatic experie
Externí odkaz:
https://doaj.org/article/e59873255f4c4f8290590e531e8d60b9
Autor:
Alvaro A. Ordonez, C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken, Sanjay K. Jain, Lorraine Jones-Brando
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Sulforaphane, a chemical found in broccoli, has known antioxidant and antiinflammatory effects. Here, the authors show that it can inhibit SARS-CoV-2 and other coronavirus infections in mammalian cells and can decrease viral load in mice when treated
Externí odkaz:
https://doaj.org/article/a6ee1679bea84b2b98163a24fb77681b
Autor:
Vickram Tejwani, Amanda McCormack, Karthik Suresh, Han Woo, Ningchun Xu, Meghan F. Davis, Emily Brigham, Nadia N. Hansel, Meredith C. McCormack, Franco R. D’Alessio
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionThere is evidence that obesity, a risk factor for asthma severity and morbidity, has a unique asthma phenotype which is less atopic and less responsive to inhaled corticosteroids (ICS). Peripheral blood mononuclear cells (PBMC) are import
Externí odkaz:
https://doaj.org/article/50375a8e19e54e6e9e99e4647ae6475e
Autor:
Santosh Dhakal, Camilo A. Ruiz-Bedoya, Ruifeng Zhou, Patrick S. Creisher, Jason S. Villano, Kirsten Littlefield, Jennie Ruelas Castillo, Paula Marinho, Anne E. Jedlicka, Alvaro A. Ordonez, Melissa Bahr, Natalia Majewska, Michael J. Betenbaugh, Kelly Flavahan, Alice R. L. Mueller, Monika M. Looney, Darla Quijada, Filipa Mota, Sarah E. Beck, Jacqueline Brockhurst, Alicia M. Braxton, Natalie Castell, Mitchel Stover, Franco R. D’Alessio, Kelly A. Metcalf Pate, Petros C. Karakousis, Joseph L. Mankowski, Andrew Pekosz, Sanjay K. Jain, Sabra L. Klein
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males than in females, including hospitalizations and deaths. Animal models
Externí odkaz:
https://doaj.org/article/c26a3303ffd040088f12495ee7b31392
Autor:
Bert K. Lopansri, Russell R. Miller III, John P. Burke, Mitchell Levy, Steven Opal, Richard E. Rothman, Franco R. D’Alessio, Venkataramana K. Sidhaye, Robert Balk, Jared A. Greenberg, Mark Yoder, Gourang P. Patel, Emily Gilbert, Majid Afshar, Jorge P. Parada, Greg S. Martin, Annette M. Esper, Jordan A. Kempker, Mangala Narasimhan, Adey Tsegaye, Stella Hahn, Paul Mayo, Leo McHugh, Antony Rapisarda, Dayle Sampson, Roslyn A. Brandon, Therese A. Seldon, Thomas D. Yager, Richard B. Brandon
Publikováno v:
Journal of Intensive Care, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and v
Externí odkaz:
https://doaj.org/article/58b777a2daf346e396ec3874647a0467
Autor:
Ye Xiong, Qiong Zhong, Tsvi Palmer, Alison Benner, Lan Wang, Karthik Suresh, Rachel Damico, Franco R. D’Alessio
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Current treatments for pneumonia (PNA) are focused on the pathogens. Mortality from PNA-induced acute lung injury (PNA-ALI) remains high, underscoring the need for additional therapeutic targets. Clinical and experimental evidence exists for potentia
Externí odkaz:
https://doaj.org/article/799e16b8da674ef0882b711b253315d2
Autor:
Julie R Brahmer, Patrick M Forde, Evan J Lipson, Jarushka Naidoo, Joanne Riemer, Daphne Wang, Janis M Taube, Cheng Ting Lin, Peter B Illei, Tricia R Cottrell, Lonny B Yarmus, K Ranh Voong, David Feller-Kopman, Hans Lee, Sonye K Danoff, Franco R D'Alessio, Karthik Suresh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Pneumonitis from immune checkpoint inhibitors (ICI) is a potentially fatal immune-related adverse event (irAE) from antiprogrammed death 1/programmed death ligand 1 immunotherapy. Most cases of ICI pneumonitis improve or resolve with 4–6
Externí odkaz:
https://doaj.org/article/244175d2173e40ba8ff2075dd57c06fb
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