Zobrazeno 1 - 10
of 702
pro vyhledávání: '"R-SMAD"'
Publikováno v:
Biology Open, Vol 4, Iss 4, Pp 573-583 (2015)
Retina formation requires the correct spatiotemporal patterning of key regulatory factors. While it is known that repression of several signaling pathways lead to specification of retinal fates, addition of only Noggin, a known BMP antagonist, can co
Externí odkaz:
https://doaj.org/article/03f9b636daae4c609b4c05b6e3140f77
Autor:
Oluwafunke A. Ajayi, Moses C. Antiya, Dorcas Ibukun Akinloye, Adio Jamiu Akamo, Samuel O. Faseun, Gogonte Hezekiah Amah, O E Eteng, O. O. Adeleye, Regina Ngozi Ugbaja, Oluwatosin A. Dosumu
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1803-1813 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Naringin inhibits and/or scavenge in vitro free radicals. • Exposure to cyclophosphamide (CYCP) invoked erythrocytotoxicity. • Erythrocytotoxicity was characterized by oxidative stress and dyslipidaemia. •
Highlights • Naringin inhibits and/or scavenge in vitro free radicals. • Exposure to cyclophosphamide (CYCP) invoked erythrocytotoxicity. • Erythrocytotoxicity was characterized by oxidative stress and dyslipidaemia. •
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638b70b3cd7e017a33c222630706c3f1
http://www.sciencedirect.com/science/article/pii/S2214750021001839
http://www.sciencedirect.com/science/article/pii/S2214750021001839
Publikováno v:
JHEP Reports, Vol 4, Iss 2, Pp 100397-(2022)
JHEP Reports
JHEP Reports
TGF-β is a very strong effector in the liver, involved in a plethora of processes initiated upon liver injury. TGF-β affects parenchymal, non-parenchymal, and inflammatory cells in a highly context-dependent manner. Its bioavailability is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c6922f0d78109475d83c4ca70e310f
http://www.sciencedirect.com/science/article/pii/S2589555921001737
http://www.sciencedirect.com/science/article/pii/S2589555921001737
Autor:
Wook Jin, Min Soo Kim
Publikováno v:
Cancers, Vol 12, Iss 1048, p 1048 (2020)
Cancers
Volume 12
Issue 4
Cancers
Volume 12
Issue 4
TrkB-mediated activation of the IL6/JAK2/STAT3 signaling pathway is associated with the induction of the epithelial&ndash
mesenchymal transition (EMT) program and the acquisition of metastatic potential by tumors. Conversely, the transforming of
mesenchymal transition (EMT) program and the acquisition of metastatic potential by tumors. Conversely, the transforming of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333099414d2b8ecb29404d1db99f9cc4
https://www.mdpi.com/2072-6694/12/4/1048
https://www.mdpi.com/2072-6694/12/4/1048
Autor:
Feng Liu, Chunqun Wang, Caixian Zhou, Fangfang Li, Jia-Nan Shan, Li He, Wenda Di, Rui Fang, Min Hu, Robin B. Gasser
Publikováno v:
Parasites & Vectors
Parasites & Vectors, Vol 13, Iss 1, Pp 1-13 (2020)
Parasites & Vectors, Vol 13, Iss 1, Pp 1-13 (2020)
BackgroundSmad proteins are essential cellular mediators within the transforming growth factor-β (TGF-β) superfamily. They directly transmit incoming signals from the cell surface receptors to the nucleus. In spite of their functional importance, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18708e07b1e9ada2377cff2cf7cc66d
http://europepmc.org/articles/PMC7119156
http://europepmc.org/articles/PMC7119156
Publikováno v:
Applied Numerical Mathematics. 133:41-51
Mammalian cells respond in a variety of ways to concentrations of activated transforming growth factor (TGF) in the extracellular domain via intracellular Smad signaling pathways. TGF-β/Smad interaction is prevalent in a wide range of tumor environm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b55c22211fa7e8353da46aa80e7a435
https://doi.org/10.1016/j.apnum.2017.11.004
https://doi.org/10.1016/j.apnum.2017.11.004
Publikováno v:
Journal of Dermatological Science. 90:13-20
Background Histone deacetylase (HDAC) is an enzyme that regulates gene expression, cell cycle arrest, apoptosis and modulation of various pathways. HDAC inhibitors (HDACis) can modulate these pathways by hyper-acetylating target proteins, thereby act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd5dc12d2d2d4dd0cccdddf05813f60
https://doi.org/10.1016/j.jdermsci.2017.12.011
https://doi.org/10.1016/j.jdermsci.2017.12.011
Autor:
Chao Wu, Anna L. Means, James R. Goldenring, Anne R. Meyer, Charles L. Sawyers, Keith T. Wilson, R. Daniel Beauchamp, M. Kay Washington, Robert J. Coffey, Tanner J. Freeman, Hanbing An, Jinghuan Zi, Connie J. Weaver, Chanjuan Shi, J. Joshua Smith, Tasia D. Brown, Luke G. Woodbury, Natasha G. Deane, Paula Marincola-Smith, Chandrasekhar Padmanabhan, Jing Zhu, Bronson C. Wessinger, Sergey V. Novitskiy, Rupesh Chaturvedi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 257-276 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 257-276 (2018)
Background & Aims Chronic inflammation is a predisposing condition for colorectal cancer. Many studies to date have focused on proinflammatory signaling pathways in the colon. Understanding the mechanisms that suppress inflammation, particularly in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3157657e3f39f515abc45b7453c902
https://doi.org/10.1016/j.jcmgh.2018.05.006
https://doi.org/10.1016/j.jcmgh.2018.05.006
Akademický článek
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Autor:
Lindsay R. Stolzenburg, Ann Harris
Publikováno v:
Cell and Tissue Research. 371:325-338
Tissue fibrosis, the development of fibrous connective tissue as a result of injury or damage, is associated with many common diseases and cannot be treated effectively. The complex biological processes accompanying fibrosis often involve aberrant si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966a0cc27888a5b105d38ed17d52bd93
https://doi.org/10.1007/s00441-017-2697-6
https://doi.org/10.1007/s00441-017-2697-6