Effect of Automated Closed-loop ventilation versus convenTional VEntilation on duration and quality of ventilation in critically ill patients (ACTiVE) – study protocol of a randomized clinical trial

Autor: Michela Botta, Anissa M. Tsonas, Jante S. Sinnige, Ashley J. R. De Bie, Alexander J. G. H. Bindels, Lorenzo Ball, Denise Battaglini, Iole Brunetti, Laura A. Buiteman–Kruizinga, Pim L. J. van der Heiden, Evert de Jonge, Francesco Mojoli, Chiara Robba, Abraham Schoe, Frederique Paulus, Paolo Pelosi, Ary Serpa Neto, Janneke Horn, Marcus J. Schultz, The ACTiVE collaborative group

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background INTELLiVENT–Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of ventilation for use in critically ill patients. Evidence for benefit of INTELLiVENT–ASV in comparison to ventilation that is not fully aut

Externí odkaz: https://doaj.org/article/ec002e06129f482dbb326bf202f8e85e

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease

Autor: Sourav K. Bose, Brandon M. White, Meghana V. Kashyap, Apeksha Dave, Felix R. De Bie, Haiying Li, Kshitiz Singh, Pallavi Menon, Tiankun Wang, Shiva Teerdhala, Vishal Swaminathan, Heather A. Hartman, Sowmya Jayachandran, Prashant Chandrasekaran, Kiran Musunuru, Rajan Jain, David B. Frank, Philip Zoltick, William H. Peranteau

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Lysosomal storage diseases like mucopolysaccharidosis type I (MPS I) cause pathology before birth and result in early morbidity and mortality. Here, the authors show that in utero base editing mediates multi-organ phenotypic and survival benefits in

Externí odkaz: https://doaj.org/article/a932a6ec2ba7497281b8dba976e50d99

Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus

Autor: Marilza V. C. Rudge, Fátima P. Souza, Joelcio F. Abbade, Raghavendra L. S. Hallur, João Paulo C. Marcondes, Fernanda Piculo, Gabriela Marini, Giovana Vesentini, Lehana Thabane, Steven S. Witkin, Iracema M. P. Calderon, Angélica M. P. Barbosa, The Diamater Study Group, M. V. Rudge, A. M. P. Barbosa, I. M. P. Calderon, F. P. Souza, J. F. Abbade, L. S. R. Hallur, F. Piculo, G. Marini, G. Vesentini, L. Thabane, M. S. Palma, C. F. O. Graeff, R. K. Arni, R. D. Herculano, D. F. Salvadori, S. Mateus, M. Dal Pai Silva, C. G. Magalhães, R. A. Costa, S. A. M. Lima, S. L. Felisbino, W. Barbosa, A. Atallah, M. J. B. Girão, Z. Di Bella, S. M. Uchoa, S. Payão, A. Hijas, B. Berghman, R. De Bie, L. Sobrevia, B. Junginger, F. C. B. Alves, P. S. Rossignoli, C. B. Prudencio, M. I. G. Orlandi, M. I. Gonçalves, S. K. Nunes, B. B. Catinelli, S. Quiroz, B. V. Sarmento, F. A. Pinheiro, C. I. Sartorão, R. R. Lucas, D. R. A. Reyes, S. B. C. V. Quiroz, E. M. A. Enriquez, R. G. Oliveira, J. F. Floriano, J. P. C. Marcondes, S. Barneze, T. D. Dangió, T. Pascon, P. Rossignoli, J. V. Freitas, L. Takano, F. Reis, T. D. Caldeirão, J. N. Fernandes, A. M. Carr, M. V. C. Gaitero, J. E. Corrente, H. R. C. Nunes, A. F. Candido, S. M. B. Costa, J. V. F. Melo, F. V. D. S. Reis, G. A. Garcia, G. B. Rabadan, H. C. M. Bassin, K. S. Suyama, L. N. Damasceno, M. L. S. Takemoto, M. D. Menezes, D. G. Bussaneli, V. K. C. Nogueira, P. R. Lima, I. O. Lourenço, J. Marostica de Sá, R. A. Megid, I. P. Caruso, L. T. Rasmussen, G. M. Prata, M. A. Arantes, G. A. R. Ferraz, L. P. Camargo, M. R. Kron

Publikováno v: BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-14 (2020)

Abstract Background Pelvic floor muscles (PFM) and rectus abdominis muscles (RAM) of pregnant diabetic rats exhibit atrophy, co-localization of fast and slow fibers and an increased collagen type I/III ratio. However, the role of similar PFM or RAM h

Externí odkaz: https://doaj.org/article/0d3f99d86d9a433a8d562ed3ae0e852a

Advanced practice providers versus medical residents as leaders of rapid response teams: A 12-month retrospective analysis

Autor: Herman G. Kreeftenberg, Ashley J. R. De Bie, Eveline H. J. Mestrom, Alexander J. G. H. Bindels, Peter H. J. van der Voort

Publikováno v: PLoS ONE, Vol 17, Iss 8 (2022)

Purpose In a time of worldwide physician shortages, the advanced practice providers (APPs) might be a good alternative for physicians as the leaders of a rapid response team. This retrospective analysis aimed to establish whether the performance of A

Externí odkaz: https://doaj.org/article/5d1c3c9266034e128a0caa6efcfcc503

Multicenter validation of preoperative motor outcome prediction for deep brain stimulation in Parkinson’s disease

Autor: J. Habets, C. Herff, A. Fasano, M. Beudel, E. Kocabicak, A. Schnitzler, M. Abu Snineh, S. Kalia, C. Ramirez, M. Hodaie, R. Munhoz, E. Rouleau, O. Yildiz, E. Linetsky, R. Schuurman, C. Hartmann, A. Lozano, R. De Bie, Y. Temel, M. Janssen

Publikováno v: Brain and Spine, Vol 1, Iss , Pp 100707- (2021)

Externí odkaz: https://doaj.org/article/b8c6fac664cc43778ff804b23cad3704