Zobrazeno 1 - 10
of 1 058
pro vyhledávání: '"R Wray"'
Autor:
Ian B Hickie, Joanne S Carpenter, Jacob J Crouse, Enda M Byrne, Sarah E Medland, Lucia Colodro-Conde, Richard Parker, Naomi R Wray, Penelope Lind, Brittany L Mitchell, Mirim Shin, Emiliana Tonini
Publikováno v:
BMJ Mental Health, Vol 27, Iss 1 (2024)
Background The COVID-19 pandemic, while a major stressor, increased flexibility in sleep–wake schedules.Objectives To investigate the impact of the pandemic on sleep patterns in people with a history of depression and identify sociodemographic, cli
Externí odkaz:
https://doaj.org/article/4ea4b358e13a41f98e1072d6b261c993
Autor:
Kathryn E. Kemper, Julia Sidorenko, Huanwei Wang, Ben J. Hayes, Naomi R. Wray, Loic Yengo, Matthew C. Keller, Michael Goddard, Peter M. Visscher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The causes of temporal fluctuations in adult traits are poorly understood. Here, we investigate the genetic determinants of within-person trait variability of 8 repeatedly measured anthropometric traits in 50,117 individuals from the UK Biob
Externí odkaz:
https://doaj.org/article/d7ac6e5c622e4251826a4171034f62b2
Autor:
Alesha A. Hatton, Fei-Fei Cheng, Tian Lin, Ren-Juan Shen, Jie Chen, Zhili Zheng, Jia Qu, Fan Lyu, Sarah E. Harris, Simon R. Cox, Zi-Bing Jin, Nicholas G. Martin, Dongsheng Fan, Grant W. Montgomery, Jian Yang, Naomi R. Wray, Riccardo E. Marioni, Peter M. Visscher, Allan F. McRae
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA methylation is an ideal trait to study the extent of the shared genetic control across ancestries, effectively providing hundreds of thousands of model molecular traits with large QTL effect sizes. We investigate cis DNAm QTLs in three E
Externí odkaz:
https://doaj.org/article/390e05448833466fa9d5072be811c288
Autor:
Anna H. Ou, Sara B. Rosenthal, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Martin Alda, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, David A. Cousins, Cristiana Cruceanu, Piotr M. Czerski, Clarissa R. Dantas, Alexandre Dayer, Maria Del Zompo, Franziska Degenhardt, J. Raymond DePaulo, Bruno Étain, Peter Falkai, Frederike Tabea Fellendorf, Ewa Ferensztajn-Rochowiak, Andreas J. Forstner, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, Sarah Kittel-Schneider, Barbara König, Po-Hsiu Kuo, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Carlos A. López Jaramillo, Glenda MacQueen, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Manuel Mattheisen, Michael J. McCarthy, Susan L. McElroy, Francis J. McMahon, Philip B. Mitchell, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novák, Urban Ösby, Norio Ozaki, Sergi Papiol, Roy H. Perlis, Claudia Pisanu, James B. Potash, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Eva Z. Reininghaus, Marcella Rietschel, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, K. Oliver Schubert, Thomas G. Schulze, Barbara W. Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Naomi R. Wray, Adam Wright, L. Trevor Young, Peter P. Zandi, John R. Kelsoe
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipo
Externí odkaz:
https://doaj.org/article/4ffae4e761e24f54b9836464e5e374c0
Autor:
Luis M. Garcia-Marin, Aoibhe Mulcahy, Enda M. Byrne, Sarah E. Medland, Naomi R. Wray, Freddy Chafota, Penelope A. Lind, Nicholas G. Martin, Ian B. Hickie, Miguel E. Rentería, Adrian I. Campos
Publikováno v:
Annals of General Psychiatry, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Background Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographic characteristics, ps
Externí odkaz:
https://doaj.org/article/2cb0835bebff4b828331aeeaf7a68282
Autor:
Xiaotong Wang, Valentin Hivert, Shiane Groot, Ying Wang, Loic Yengo, John J McGrath, Kathryn E Kemper, Peter M Visscher, Naomi R Wray, Joana A Revez
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011033 (2023)
Vitamin D status-a complex trait influenced by environmental and genetic factors-is tightly associated with skin colour and ancestry. Yet very few studies have investigated the genetic underpinnings of vitamin D levels across diverse ancestries, and
Externí odkaz:
https://doaj.org/article/f88493a2708348eeb81b39239f4f8f1a
Autor:
Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100385- (2023)
Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) o
Externí odkaz:
https://doaj.org/article/97272e77d4a5469f8c556d16c5b5034e
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Microarray technology has been used to measure genome-wide DNA methylation in thousands of individuals. These studies typically test the associations between individual DNA methylation sites (“probes”) and complex traits or diseases. The
Externí odkaz:
https://doaj.org/article/dcc7c30d3c2e45608ba5a52f4a21878e
Autor:
Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, John J. McGrath
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of
Externí odkaz:
https://doaj.org/article/15845a4d45ac43fd9c945f9f49a9c9cc
Autor:
Zhen Qiao, Julia Sidorenko, Joana A. Revez, Angli Xue, Xueling Lu, Katri Pärna, Harold Snieder, Lifelines Cohort Study, Peter M. Visscher, Naomi R. Wray, Loic Yengo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demo
Externí odkaz:
https://doaj.org/article/6fde8113956e402caba8686de06ed2d1