Zobrazeno 1 - 10
of 71
pro vyhledávání: '"R Weyhenmeyer"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 42:543-549
Background and objectives: The antimuscarinic drug trospium chloride is hydrophilic and therefore does not enter the CNS when used for the treatment of overactive bladder disturbances. However, the same property is the main reason for low and variabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37591d636ec0d11ee98297790d33aff9
https://doi.org/10.5414/cpp42543
https://doi.org/10.5414/cpp42543
Autor:
S Beckmann-Knopp, R Weyhenmeyer, S Rietbrock, W Lang, K T Beckurts, R. Böcker, M Hunz, Uwe Fuhr
Publikováno v:
Pharmacologytoxicology. 86(6)
Silibinin, the main constituent of silymarin, a flavonoid drug from silybum marianum used in liver disease, was tested for inhibition of human cytochrome P-450 enzymes. Metabolic activities were determined in liver microsomes from two donors using se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1d6a5322045448fb06e77555fb406
https://pubmed.ncbi.nlm.nih.gov/10895987
https://pubmed.ncbi.nlm.nih.gov/10895987
Publikováno v:
Pharmacologytoxicology. 85(6)
Trospium chloride, an atropine derivative used for the treatment of urge incontinence, was tested for inhibitory effects on human cytochrome P450 enzymes. Metabolic activities were determined in liver microsomes from two donors using the following se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cebf6921711e86d7f61972834529992
https://pubmed.ncbi.nlm.nih.gov/10628907
https://pubmed.ncbi.nlm.nih.gov/10628907
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
The biochemical influence of flavonolignans from the milk thistle Silybum marianum has been tested on kidney cells of African green monkeys. Two nonmalignant cell lines were selected, with the focus of the work on the fibroblast-like Vero line. Proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b643e4818269d526c89385ec65cbf85c
https://pubmed.ncbi.nlm.nih.gov/10454517
https://pubmed.ncbi.nlm.nih.gov/10454517
Autor:
K, Weber, U, Mengs, T, Schwarz, T, Hajto, K, Hostanska, T R, Allen, R, Weyhenmeyer, H, Lentzen
Publikováno v:
Arzneimittel-Forschung. 48(5)
The immune response-modifying drug Lektinol is a mistletoe preparation which is standardized with respect to bioactive viscum album agglutinin, the most active component of mistletoe. The present study was designed to evaluate the antimetastatic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::349a63e167c591c99494f16b758da528
https://pubmed.ncbi.nlm.nih.gov/9638318
https://pubmed.ncbi.nlm.nih.gov/9638318
Publikováno v:
Arzneimittel-Forschung. 48(3)
Low density lipoprotein (LDL) oxidation and smooth muscle cell growth represent key events in atherogenesis. Any mean to reduce these two phenomena may decrease the risk of coronary artery disease and atherosclerosis in general. The effects of silibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::027568d24d181682b140ad10e578c0e1
https://pubmed.ncbi.nlm.nih.gov/9553679
https://pubmed.ncbi.nlm.nih.gov/9553679
Publikováno v:
Arzneimittel-Forschung. 47(12)
Hepatic stellate cells and the derived myofibroblasts play a central pathogenic role in liver fibrogenesis. In order to identify the still unknown hepatoprotective properties of the flavonoid silibinin and the related pyridylchromone NH40 x HCl (2-(3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1c296fd832e39b9e54cb122eaea4ec5
https://pubmed.ncbi.nlm.nih.gov/9450168
https://pubmed.ncbi.nlm.nih.gov/9450168
Publikováno v:
Arzneimittel-Forschung. 46(6)
The mistletoe preparation Lektinol is standardized with respect to bioactive mistletoe lectin, the active component of mistletoe. This standardized mistletoe preparation and its active components (mistletoe lectins) were compared in the skin2 bioassa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6eebe427193c3937cae50915b53fcf50
https://pubmed.ncbi.nlm.nih.gov/8767360
https://pubmed.ncbi.nlm.nih.gov/8767360
Publikováno v:
Journal of chromatography. B, Biomedical applications. 670(2)
A combination of two stereoselective assays was developed using column-switching HPLC with electrochemical detection for the determination of free (unconjugated) silibinin and RP-HPLC with UV detection for the measurement of total (free and conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be4e46de60fbf28b68a77c04649f52b
https://pubmed.ncbi.nlm.nih.gov/8548017
https://pubmed.ncbi.nlm.nih.gov/8548017
Publikováno v:
Arzneimittel-Forschung. 45(1)
Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin (CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f8048e139251c9beae52128dc613c6b
https://pubmed.ncbi.nlm.nih.gov/7893272
https://pubmed.ncbi.nlm.nih.gov/7893272