Zobrazeno 1 - 10
of 407
pro vyhledávání: '"R Wesolowski"'
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Dong Wang, Eric M. Pietras, Rachel C. Janssen, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102849- (2024)
Summary: Studying fetal hematopoiesis is challenging as hematopoiesis transitions from the liver to bone marrow. Obtaining human samples is not possible, and small animal models may not provide sufficient biological material. Here, we present a proto
Externí odkaz:
https://doaj.org/article/1408351a7a1948bd90187a6ca66f9581
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D’Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0014-e0014 (2023)
Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in
Externí odkaz:
https://doaj.org/article/6bcad75da676422bbcbdb90a6e13d609
Autor:
Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a
Externí odkaz:
https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Sean A. Newsom, Ilhem Messaoudi, Rachel C. Janssen, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Paul Kievit, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Maternal obesity affects nearly one-third of pregnancies and is a major risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescent offspring, yet the mechanisms behind NAFLD remain poorly understood. Here, we demonstrate that nonhuman pri
Externí odkaz:
https://doaj.org/article/74abddaa583647bc9452d4301229be48
Autor:
Eileen I. Chang, Byron Hetrick, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul J. Rozance, Laura D. Brown
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Intrauterine growth restricted (IUGR) fetuses are born with lower skeletal muscle mass, fewer proliferating myoblasts, and fewer myofibers compared to normally growing fetuses. Plasma concentrations of insulin, a myogenic growth factor, are lower in
Externí odkaz:
https://doaj.org/article/19521035d3f24affba43750c2b55aeb7
Autor:
Amanda K. Jones, Paul J. Rozance, Laura D. Brown, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Sean W. Limesand, Stephanie R. Wesolowski
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear. This study tested the effects of maternal hypoxemia (HOX) between 0.8 and
Externí odkaz:
https://doaj.org/article/6d39b3d4d081446c8544893989d2a34f
Autor:
Stephanie R. Wesolowski, Christopher M. Mulligan, Rachel C. Janssen, Peter R. Baker, II, Bryan C. Bergman, Angelo D'Alessandro, Travis Nemkov, Kenneth N. Maclean, Hua Jiang, Tyler A. Dean, Diana L. Takahashi, Paul Kievit, Carrie E. McCurdy, Kjersti M. Aagaard, Jacob E. Friedman
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 25-41 (2018)
Objective: Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dieta
Externí odkaz:
https://doaj.org/article/a28561519af14a2b8a154ec639481f85
Autor:
Alexander L. Pendleton, Stephanie R. Wesolowski, Timothy R. H. Regnault, Ronald M. Lynch, Sean W. Limesand
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Intrauterine growth restriction (IUGR) of the fetus, resulting from placental insufficiency (PI), is characterized by low fetal oxygen and nutrient concentrations that stunt growth rates of metabolic organs. Numerous animal models of IUGR recapitulat
Externí odkaz:
https://doaj.org/article/fb182e110b44438d8eb08377868b43c6