Zobrazeno 1 - 10
of 1 438
pro vyhledávání: '"R Wahl"'
Autor:
Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-l
Externí odkaz:
https://doaj.org/article/b60128e341cf4e8c9deb69669f6c0187
Autor:
Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M
Externí odkaz:
https://doaj.org/article/1951e061c7ab4540990fd8c2ffa35723
Publikováno v:
Communications Earth & Environment, Vol 3, Iss 1, Pp 1-14 (2022)
The ongoing bidecadal drought in the Southwest USA is thed most severe since 800 CE, with the moisture regime projected to remain consistently drier in the region, according to paleoclimate reconstructions, modern data and numerical climate model sim
Externí odkaz:
https://doaj.org/article/f211fb47d02d4e01b417377cdc9b0ed2
Autor:
Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, Roya AminiTabrizi, Hardik Shah, Rosa Elena Menjivar, Andrew J Scott, Zeribe C Nwosu, Zhou Zhu, Riona N Chen, Moses Oh, Colin Sheehan, Daniel R Wahl, Marina Pasca di Magliano, Costas A Lyssiotis, Kay F Macleod, Christopher R Weber, Alexander Muir
Publikováno v:
eLife, Vol 12 (2023)
Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is criti
Externí odkaz:
https://doaj.org/article/c5f718ce140e4a6fa50f1ed1f45d288d
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
Externí odkaz:
https://doaj.org/article/0d2d630dc0a747b8807be46604e76da1
Autor:
McKinley, B., Tingay, S. J., Carretti, E., Ellis, S., Bland-Hawthorn, J., Morganti, R., Line, J., McDonald, M., Veilleux, S., Olsen, R. Wahl, Sidonio, M., Ekers, R., Offringa, A. R., Procopio, P., Pindor, B., Wayth, R. B., Hurley-Walker, N., Bernardi, G., Gaensler, B. M., Haverkorn, M., Kesteven, M., Poppi, S., Staveley-Smith, L.
We present new radio and optical images of the nearest radio galaxy Centaurus A and its host galaxy NGC 5128. We focus our investigation on the northern transition region, where energy is transported from the ~5 kpc (~5 arcmin) scales of the Northern
Externí odkaz:
http://arxiv.org/abs/1711.01751
Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 37, Iss , Pp 100881- (2023)
Diffuse intrinsic pontine glioma (DIPG) is a rare but highly lethal pediatric and adolescent tumor located in the pons of the brainstem. DIPGs harbor unique and specific pathological and molecular alterations, such as the hallmark lysine 27-to-methio
Externí odkaz:
https://doaj.org/article/5c4a8a9a375f4f1aa8daa5602e314018
Autor:
Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel GW Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 36, Iss , Pp 100872- (2023)
Purpose: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities. Experimental design: We developed a
Externí odkaz:
https://doaj.org/article/a0132180ec4b462dbadc5529f928818b
Publikováno v:
BMC Nutrition, Vol 7, Iss 1, Pp 1-5 (2021)
Abstract Background Sugar overconsumption is a major contributor to overweight and obesity, with daily consumption greatly exceeding the WHO’s recommendations. The aim of the present study was to determine whether using a functionally modified suga
Externí odkaz:
https://doaj.org/article/401df3aa65c74a9cab6aeec760bfe174
Autor:
Nicholas R. Rydzewski, Erik Peterson, Joshua M. Lang, Menggang Yu, S. Laura Chang, Martin Sjöström, Hamza Bakhtiar, Gefei Song, Kyle T. Helzer, Matthew L. Bootsma, William S. Chen, Raunak M. Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel R. Wahl, Felix Y. Feng, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, w
Externí odkaz:
https://doaj.org/article/683460200e2546bd8518fb156fad7efa