Zobrazeno 1 - 10
of 50
pro vyhledávání: '"R W Stevenson"'
Autor:
Terrell A. Patterson, James V. Cassella, Paul DaSilva-Jardine, R W Stevenson, Li She, Diane M. Hargrove, Kelly A. Martin, Richard L. Elliott, Robert M. Oliver, Marlys Hammond, Christine M. Mack, J. Cory Kalvass, Tristan S. Maurer, Morgan Bradley P
Publikováno v:
Journal of Medicinal Chemistry. 46:670-673
To investigate the anorectic potential of NPY5 receptor antagonists, we have profiled the in vitro and in vivo properties of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt (1). This compound was found to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d1e1b4a42bca5bdaeb1525ab350af7
https://doi.org/10.1021/jm025584p
https://doi.org/10.1021/jm025584p
Autor:
Dennis J. Hoover, William H. Martin, R W Stevenson, Dennis E. Danley, Judith L. Treadway, Ingrid A. Stock, E J Barrett, Sandra J Armento, R K McPherson
Publikováno v:
Proceedings of the National Academy of Sciences. 95:1776-1781
An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro and in vivo . This substance, [R-(R*,S*)]-5-chloro- N -[3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide (CP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb57b765b8e36cceb3e42be1d20a779a
https://doi.org/10.1073/pnas.95.4.1776
https://doi.org/10.1073/pnas.95.4.1776
Publikováno v:
Diabetes. 47:179-185
The aim of this study was to compare the effects of insulin and the insulinomimetic agent, englitazone, on functional end points and putative mediators of insulin action in 3T3-L1 adipocytes. Cells were incubated with englitazone for 48 h or with ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2465d9940a1f277538f52141e5711
https://doi.org/10.2337/diabetes.47.2.179
https://doi.org/10.2337/diabetes.47.2.179
Autor:
Fran E. Kaiser, Beatrice J. Edwards, Horace M. Perry, John E. Morley, David K. Kreutter, D. Kraenzle, R W Stevenson
Publikováno v:
Mechanisms of Ageing and Development. 87:61-73
Falls following a meal occur commonly in older persons. These falls have been related to a decrease in postprandial blood pressure due to carbohydrates in the meal. The mechanism by which this occurs is not known. In this study, we examined the possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8793ce983a3663c0c57989d7001634
https://doi.org/10.1016/0047-6374(96)01688-0
https://doi.org/10.1016/0047-6374(96)01688-0
Autor:
R W Stevenson, J Spitzer, A G Swick, P. E. Genereux, K. M. Andrews, J J Herbst, R K McPherson, L M Persson, David K. Kreutter, E. M. Gibbs
Publikováno v:
Diabetes. 45:60-66
The effects of englitazone in male Wistar rats fed a high-fat diet (59% of calories as fat) were compared with control rats fed a high-carbohydrate diet (69% of calories as carbohydrate) (5–15 animals per group). Insulin-stimulated (17 nmol/l) 2-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b016a6f1f2956597a68c3bd521265e3d
https://doi.org/10.2337/diabetes.45.1.60
https://doi.org/10.2337/diabetes.45.1.60
Publikováno v:
Metabolism. 44:1231-1237
In vitro, truncated glucagon-like peptides [GLP-1(7-36)-amide and GLP-1(7-37)] increase insulin secretion in a glucose-dependent manner, and desensitization to the action of GLP-1(7-37) has been demonstrated acutely with high concentrations. The purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ed7847b8912684ae9ed5e79204906
https://doi.org/10.1016/0026-0495(95)90021-7
https://doi.org/10.1016/0026-0495(95)90021-7
Autor:
E M Gibbs, R W Stevenson, Scott C. McCoid, Anthony J. Milici, Jeffrey E. Pessin, H A Stukenbrok, John D. McNeish, Jeffrey L. Stock
Publikováno v:
Journal of Clinical Investigation. 95:1512-1518
The effects of increased GLUT4 (insulin-regulatable muscle/fat glucose transporter) expression on glucose homeostasis in a genetic model of non-insulin-dependent diabetes mellitus were determined by expressing a human GLUT4 transgene (hGLUT4) in diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a827913dd3dbf76cf28b53220954c1
https://doi.org/10.1172/jci117823
https://doi.org/10.1172/jci117823
Autor:
Nancy A. Nardone, J E Pessin, J F Russo, Diane M. Hargrove, R. K. Mcpherson, E M Gibbs, H A Stukenbrok, Anthony J. Milici, Judith L. Treadway, R W Stevenson
Publikováno v:
Journal of Biological Chemistry. 269:29956-29961
Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance compared with nontransgenic controls (Liu, M.-L., Gibbs, E. M., McCoid, S. C., Milici, A. J., S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf56a53d92a876557bd08d74bbb38f4b
https://doi.org/10.1016/s0021-9258(18)43974-9
https://doi.org/10.1016/s0021-9258(18)43974-9
Autor:
R W, Stevenson
Publikováno v:
Canadian family physician Medecin de famille canadien. 32
Sexual rehabilitation begins with an awareness of the potential for sex difficulties following any disruption in health. A thorough sex-functioning history and an exploration of the patient's (and partner's) expectations, limitations and potentials w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8a0bbff6f5e957fdbed996855e174f7
https://pubmed.ncbi.nlm.nih.gov/21267289
https://pubmed.ncbi.nlm.nih.gov/21267289
Publikováno v:
Metabolism. 42:1583-1587
We examined effects of a novel antidiabetic agent, racemic englitazone (CP 68,722, Pfizer), on normal rat hepatocytes in vitro. For optimal effects, CP 68,722 must be preincubated for approximately 20 minutes. CP 68,722 inhibited the actions of gluca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c69eced6244c3a66d2bdb5b5496c9e6
https://doi.org/10.1016/0026-0495(93)90154-g
https://doi.org/10.1016/0026-0495(93)90154-g