Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R W Setzer"'
Autor:
Gregory S Honda, Robert G Pearce, Ly L Pham, R W Setzer, Barbara A Wetmore, Nisha S Sipes, Jon Gilbert, Briana Franz, Russell S Thomas, John F Wambaugh
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic
Externí odkaz:
https://doaj.org/article/dd304bfaf4ec40dcb06257731d4d94e3
Autor:
Nisha S. Sipes, Ly Ly Pham, Robert G. Pearce, Jon Gilbert, R. W. Setzer, Russell S. Thomas, Gregory S. Honda, John F. Wambaugh, Briana Franz, Barbara A. Wetmore
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic
Autor:
R. W. Setzer, Janet J. Diliberto, Linda S. Birnbaum, Ralph J. Smialowicz, Wanda C. Williams, Deborah E. Burgin
Publikováno v:
Toxicology. 197:15-22
One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to sheep red blood cells (SRBCs) in mice. Immunosuppression occurs in concert with hepatom
Autor:
R. W. Setzer, C. A. Kimmel
Publikováno v:
Pure and Applied Chemistry. 75:2151-2158
The benchmark dose (BMD) is the dose of a substance that is expected to result in a prespecified level of effect, the benchmark response level or BMR. It is a general approach to characterizing dose response, applicable to any toxicant and endpoint.
Publikováno v:
Reproductive Toxicology. 11:179-184
The purpose of this study is to determine whether sperm nuclear size, shape, and chromatin texture parameters are associated with lifestyle exposures including smoking, caffeine, and alcohol consumption. Eighty-six healthy male volunteers (ages 18-35
Autor:
Robert J. Kavlock, R W Setzer
Publikováno v:
Environmental Health Perspectives
The goal of researchers working in the area of developmental toxicology is to prevent adverse reproductive outcomes (early pregnancy loss, birth defects, reduced birth weight, and altered functional development) in humans due to exposures to environm
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:1336-1345
Ozone may play a significant role in the exacerbation of airway disease in asthmatics, either by priming the airway mucosa such that cellular responses to allergen are enhanced or by exerting an intrinsic effect on airway inflammation. Previous inves
Publikováno v:
Environmental Health Perspectives
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses. In rat liver, 12 dose-response studies of 7 different promoters (phenobarbital,
Publikováno v:
Journal of General Virology. 72:2653-2660
Detailed analysis of the selection process in serial co-infections of cell cultures by wild-type Autographa californica nuclear polyhedrosis virus (AcNPV) strain E2 (AcNPV/E2) and Ac360-beta-gal, a genetically engineered strain, shows that the unalte
Autor:
J. M. Rogers, R. W. Setzer
Publikováno v:
Teratology. 46:105-107