Výsledky vyhledávání

Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdiolate in the male C57BL/6 mouse

Autor: R. W. Nims, T. House, L. K. Keefer, J. E. Saavedra, S. F. Stinson, C. Bramhall

Publikováno v: Xenobiotica. 32:339-347

1. The single-dose plasma pharmacokinetics of O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) following intravenous (i.v.) and intraperitoneal (i.p.) bolus administration to the male C57BL/6 mouse was studied in an effort to chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ffe94c3f794c05924941236fa1aed
https://doi.org/10.1080/00498250110102665

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Reaction Kinetics for Nitrosation of Cysteine and Glutathione in Aerobic Nitric Oxide Solutions at Neutral pH. Insights into the Fate and Physiological Effects of Intermediates Generated in the NO/O2 Reaction

Autor: D A, Wink, R W, Nims, J F, Darbyshire, D, Christodoulou, I, Hanbauer, G W, Cox, F, Laval, J, Laval, J A, Cook, M C, Krishna

Publikováno v: Chemical Research in Toxicology. 7:519-525

The critical regulatory function of nitric oxide (NO) in many physiologic processes is well established. However, in an aerobic aqueous environment NO is known to generate one or more reactive and potentially toxic nitrogen oxide (NOx) metabolites. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3e8aa862a67ce37456436a1fc1cf56
https://doi.org/10.1021/tx00040a007

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Detection of adventitious viruses in biologicals--a rare occurrence

Autor: R W, Nims

Publikováno v: Developments in biologicals. 123

Adventitious virus assays are performed as part of raw materials testing, cell-line characterization, and lot-release testing of biologicals such as monoclonal antibodies, gene therapy vectors, recombinant proteins, and vaccines. The testing methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef8e99e6d6a1ce0520e448c44f25bda7
https://pubmed.ncbi.nlm.nih.gov/16566443

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In vivo induction and in vitro inhibition of hepatic cytochrome P450 activity by the benzodiazepine anticonvulsants clonazepam and diazepam

Autor: R W, Nims, R A, Prough, C R, Jones, D L, Stockus, K H, Dragnev, P E, Thomas, R A, Lubet

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(6)

The ability of the benzodiazepines, as a chemical class, to cause the induction and/or inhibition of cytochromes P450 has not been well characterized. In the present study, the induction of the cytochrome P450 2B subfamily (CYP2B) in vivo and the inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbbd054202ba4e203f2aa393f900fb5e
https://pubmed.ncbi.nlm.nih.gov/9193878

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Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat

Autor: R W, Nims, R M, McClain, P S, Manchand, P S, Belica, P E, Thomas, D W, Mellini, W E, Utermahlen, R A, Lubet

Publikováno v: The Journal of pharmacology and experimental therapeutics. 270(1)

To explore further the structural requirements for ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of CYP2B induction by 5,5-diphenylbarbituric acid, phenytoin (5,5-diphenylhydantoin), barbital (5,5-diethylbarbituric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d899bcf72b129ec352ca7ed5f8787303
https://pubmed.ncbi.nlm.nih.gov/8035330

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Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzne (TCPOBOP) in rat and cultured rat hepatocytes

Autor: R W Nims, J. F. Sinclair, D. W. Mellini, Konstantin H. Dragnev, Ronald A. Lubet, P. R. Sinclair, Paul E. Thomas, Collins R. Jones

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 23(12)

1. The dose-response relationships for hepatic CYP2B induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) were examined in the male F344/NCr rat. TCPOBOP, administered for 14 days at 0-1000 ppm in the diet, caused concentration-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b13825a7e87432fcb915bd34d6254b9
https://pubmed.ncbi.nlm.nih.gov/7510916

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