Zobrazeno 1 - 10
of 73
pro vyhledávání: '"R W Karr"'
Autor:
P A Morton, X T Fu, J A Stewart, K S Giacoletto, S L White, C E Leysath, R J Evans, J J Shieh, R W Karr
Publikováno v:
The Journal of Immunology. 156:1047-1054
CTLA-4 expressed on activated T cells binds to CD80 (B7-1) and CD86 (B7-2) molecules present on APC with high avidity and appears to deliver a negative regulatory signal to the T cell. We have investigated the kinetics of CTLA-4 binding to CD80 and C
Autor:
Dimitri S. Monos, A R Ahmed, K Bhol, R W Karr, Kai W. Wucherpfennig, Jack L. Strominger, B Yu, Elias G. Argyris
Publikováno v:
Proceedings of the National Academy of Sciences. 92:11935-11939
Human T-cell-mediated autoimmune diseases are genetically linked to particular alleles of MHC class II genes. Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is linked to a rare subtype of HLA-DR4 (DRB1*0402, 1 of 22 kno
Autor:
J M McNicholl, W C Whitworth, F Oftung, X Fu, T Shinnick, P E Jensen, M Simon, R M Wohlhueter, R W Karr
Publikováno v:
The Journal of Immunology. 155:1951-1963
We identified functionally important regions of the DR(alpha, beta 1*0401) peptide binding site and present a model of bound peptide. DR(alpha, beta 1*0401)-restricted T cell recognition and peptide binding of Mycobacterium leprae (ML) peptide 38-50
Autor:
Elisa Bono, R W Karr, J Hammer, Jeanmarie Guenot, Fabio Gallazzi, Zoltan A. Nagy, Francesco Sinigaglia, Paola Valsasnini
Publikováno v:
The Journal of Experimental Medicine
We have investigated whether sequence 67 to 74 shared by beta chains of rheumatoid arthritis (RA)-associated HLA-DR molecules imparts a specific pattern of peptide binding. The peptide binding specificity of the RA-associated molecules, DRB1*0401, DR
Publikováno v:
The Journal of Immunology. 153:5564-5571
The four members of the HLA-DR11 family of class II molecules vary only by three or fewer amino acids via dimorphisms among DR beta-chain residues 67, 71, and 86. However, they differ markedly in their abilities to induce proliferation of DR(alpha,be
Publikováno v:
Scandinavian Journal of Immunology. 39:539-550
A shared amino-acid sequence on the alpha helix of certain DR beta 1 chains is predicted to generate a 'shared epitope' that is implicated in susceptibility to the development of rheumatoid arthritis (RA). Different relative risks (RR) for disease su
Autor:
Xin-Ting Fu, R W Karr
Publikováno v:
Human Immunology. 39:253-260
The structure-function relationships of the HLA-DR alpha chain have been analyzed by identifying DR alpha residues involved in several nonpolymorphic and polymorphic antibody epitopes. Antibody binding to transfectants expressing a WT or mutant DR al
Publikováno v:
The Journal of Immunology. 148:2703-2708
We have examined the role of 12 polymorphic residues of the beta-chain of the HLA-DR1 class II molecule in T cell recognition of an epitope of pertussis toxin. Murine L cell transfectants expressing wild-type or mutant DR1 molecules (containing singl
Publikováno v:
Human Immunology. 32:150-155
cDNA sequencing of the first domains of DRB1, DRB3, DQA1, and DQB1 alleles was used to examine the extent of diversity in American black individuals expressing several DRw11 haplotypes. In addition to previously described DRw11 alleles, DRB1*1102 and
Publikováno v:
The Journal of Immunology. 146:4264-4270
The contributions to allorecognition of polymorphic amino acids in the HLA-DR7 beta 1 chain were analyzed by using mutant DR7 beta 1 chains with single amino acid substitutions at position 4, 11, 13, 25, 30, 37, 57, 60, 67, 70, 71, 74, or 78. Transfe