Zobrazeno 1 - 10 of 224 pro vyhledávání: '"R W Colman"'
2
Kallikrein-kininogen system activation and bradykinin (B2) receptors in indomethacin induced enterocolitis in genetically susceptible Lewis rats
Autor: A. A. Adam, C Blais, I Stadnicka, R. Janardham, Antoni Stadnicki, Ryan Balfour Sartor, R. W. Colman
Publikováno v: Gut. 43:365-374
Background—The plasma kallikrein-kinin (K-K) system is activated in acute and chronic relapsing intestinal inflammation induced in Lewis rats by intramural injection of exogenous bacterial components.Aims—To determine whether this effect is model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf95b427b2bdaaf736d7d4369b38c919
https://doi.org/10.1136/gut.43.3.365
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3
Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass
Autor: Drake Ta, L. H. Edmunds, Judith H. Chung, R. W. Colman, A. K. Rao, Nicolas Gikakis
Publikováno v: Circulation. 93:2014-2018
Background Coagulation during cardiopulmonary bypass (CPB) traditionally has been attributed to activation of the contact system of plasma proteins and the intrinsic coagulation pathway by blood contact with negatively charged surfaces not lined by e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1059cf1a965500762e07c0d308cedfde
https://doi.org/10.1161/01.cir.93.11.2014
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4
Inhibition of factor XII in septic baboons attenuates the activation of complement and fibrinolytic systems and reduces the release of interleukin-6 and neutrophil elastase
Autor: M.C. Brouwer, Fletcher B. Taylor, I. W. De Jong, R. W. Colman, P. M. Jansen, A. C. K. Chang, R. A. Pixley, C. E. Hack
Publikováno v: Blood. 87:2337-2344
In previous studies, we have shown that administration of monoclonal antibody (MoAb) C6B7 against human factor XII to baboons challenged with a lethal dose of Escherichia coli abrogates activation of the contact system and modulates secondary hypoten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::751b6842678f4d15b0219a4279c57899
https://doi.org/10.1182/blood.v87.6.2337.bloodjournal8762337
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6
Platelet cAMP and cGMP Phosphodiesterases
Autor: R. W. Colman, S. B. Sheth
Publikováno v: Platelets. 6(2)
Platelets respond to a wide variety of exogenous agonists that bind to distinct receptors on the platelet surface resulting in the intracellular generation of second messengers or the opening of ion channels, setting off a cascade of events leading t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722976717117230ab05b42e6596154ff
https://pubmed.ncbi.nlm.nih.gov/21043695
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7
Human factor XII (Hageman factor) autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies
Autor: R A Pixley, German B. Villanueva, R W Colman, M A Villanueva, Mathew Samuel
Publikováno v: Journal of Biological Chemistry. 267:19691-19697
The first event leading to the activation of the plasma kallikrein-kinin system is the surface-dependent conversion of factor XII to an active enzyme. Factor XII autoactivation was investigated using dextran sulfate as a soluble activating surface, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29cf4cde7d5ce42a1aea4badf3c6598
https://doi.org/10.1016/s0021-9258(18)41830-3
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8
Alpha 2-macroglobulin-kallikrein complexes detect contact system activation in hereditary angioedema and human sepsis
Autor: N, Kaufman, J D, Page, R A, Pixley, R, Schein, A H, Schmaier, R W, Colman
Publikováno v: Blood. 77:2660-2667
Activation of the contact system has been documented in severe sepsis and hereditary angioedema, but a sensitive, specific, and quantitative assay for assessing the degree of involvement of this proteolytic enzyme cascade is not yet available. We hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3092e56dd184fc2e007c110f644924eb
https://doi.org/10.1182/blood.v77.12.2660.bloodjournal77122660
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9
Membrane expression of platelet calpain
Autor: A H, Schmaier, H N, Bradford, D, Lundberg, A, Farber, R W, Colman
Publikováno v: Blood. 75:1273-1281
Platelet calpain has many platelet substrates, including external membrane proteins. We thus investigated whether platelet calpain II was associated with platelet membranes in unstimulated and thrombin- activated platelets. A monospecific, goat polyc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d402863c998bdc360a8092c795b92d20
https://doi.org/10.1182/blood.v75.6.1273.bloodjournal7561273
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10
Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases
Autor: J M, Manns, K J, Brenna, R W, Colman, S B, Sheth
Publikováno v: Thrombosis and haemostasis. 87(5)
Platelets contain two cAMP phosphodiesterases (PDEs) which regulate intracellular cAMP levels, cGMP-inhibited cAMP PDE (PDE3A) and cGMP-stimulated PDE (PDE2A). Using the PDE3 inhibitor, milrinone and the PDE2 inhibitor, erythro-9-(2-hydroxyl-3-nonyl)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f05e71132a2e7356e416b5d05dd7b03f
https://pubmed.ncbi.nlm.nih.gov/12038792
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