Zobrazeno 1 - 10
of 93
pro vyhledávání: '"R W Chesnut"'
Autor:
G Y, Ishioka, J, Fikes, G, Hermanson, B, Livingston, C, Crimi, M, Qin, M F, del Guercio, C, Oseroff, C, Dahlberg, J, Alexander, R W, Chesnut, A, Sette
Publikováno v:
The Journal of Immunology. 162:3915-3925
We engineered a multiepitope DNA minigene encoding nine dominant HLA-A2.1- and A11-restricted epitopes from the polymerase, envelope, and core proteins of hepatitis B virus and HIV, together with the PADRE (pan-DR epitope) universal Th cell epitope a
Autor:
S, Southwood, J, Sidney, A, Kondo, M F, del Guercio, E, Appella, S, Hoffman, R T, Kubo, R W, Chesnut, H M, Grey, A, Sette
Publikováno v:
The Journal of Immunology. 160:3363-3373
The peptide binding specificities of HLA-DRB1*0401, DRB1*0101, and DRB1*0701 have been analyzed by the use of large collections of synthetic peptides corresponding to naturally occurring sequences. The results demonstrated that nearly all peptides bi
Publikováno v:
Scopus-Elsevier
The present study was designed to determine if highly conserved hepatitis B virus (HBV)-derived peptides that bind multiple HLA class I alleles with high affinity are recognized as cytotoxic T lymphocyte (CTL) epitopes in acutely infected patients. P
Autor:
Rafi Ahmed, S Southwood, J Sidney, J Alexander, R. J. Concepcion, R W Chesnut, R G van der Most, Alessandro Sette, C Oseroff
Publikováno v:
Journal of Virology. 71:5110-5114
The cytotoxic T-lymphocyte response against lymphocytic choriomeningitis virus (LCMV) in BALB/c mice is predominantly directed against a single, Ld-restricted epitope in the viral nucleoprotein (residues 118 to 126). To investigate whether any Kd/Dd-
Autor:
A Vitiello, L Yuan, R W Chesnut, J Sidney, S Southwood, P Farness, M R Jackson, P A Peterson, A Sette
Publikováno v:
The Journal of Immunology. 157:5555-5562
In the present study, a systematic analysis of the influenza (Flu) PR8 determinants recognized by H-2b mice was undertaken. A single Db-restricted immunodominant epitope (NP(366)) was previously known in this system. Twenty-three different Flu PR8-de
Autor:
R G van der Most, A Sette, C Oseroff, J Alexander, K Murali-Krishna, L L Lau, S Southwood, J Sidney, R W Chesnut, M Matloubian, R Ahmed
Publikováno v:
The Journal of Immunology. 157:5543-5554
The cytotoxic T cell response against lymphocytic choriomeningitis virus (LCMV) in BALB/c (H-2d) mice is predominantly directed against a single immunodominant Ld-restricted epitope in the viral nucleoprotein (NP118-126). Here we report that the immu
Publikováno v:
The Journal of Immunology. 157:3480-3490
The HLA-B7-like binding supertype includes several different HLA-B molecules. Herein, the primary and secondary anchor specificities of the five most common HLA-B7-like molecules (B*0702, B*3501, B51, B*5301, and B*5401) were defined by the use of mo
Autor:
A Vitiello, Howard M. Grey, R W Chesnut, P A Wentworth, Alessandro Sette, Elissa Keogh, J Sidney
Publikováno v:
European Journal of Immunology. 26:97-101
HLA-A2.1-binding peptides (n = 38) were screened for immunogenicity with human peripheral blood mononuclear cells in cytotoxic T lymphocyte (CTL) induction experiments in vitro and with splenocytes from HLA-A2.1/Kb transgenic mice following immunizat
Autor:
A Kondo, J Sidney, S Southwood, M F del Guercio, E Appella, H Sakamoto, E Celis, H M Grey, R W Chesnut, R T Kubo, A Sette
Publikováno v:
The Journal of Immunology. 155:4307-4312
The binding capacity of large sets of peptides corresponding to naturally occurring sequences and carrying previously defined A24-specific motifs was analyzed. It was found that only a minority (9-25%) of the motif-carrying peptides bound the relevan
Publikováno v:
The Journal of Experimental Medicine
Transgenic murine lines have been constructed that express a chimeric class I molecule composed of the alpha 1 and alpha 2 domains of HLA-A2.1 and the alpha 3, transmembrane, and cytoplasmic domains of H-2Kb. Upon immunization with influenza virus, t