Zobrazeno 1 - 10
of 20
pro vyhledávání: '"R W Buckheit"'
Publikováno v:
Chemistry of Heterocyclic Compounds. 40:37-42
New 2-[2-(3,5-dimethylphenoxy)ethyl]thio derivatives of pyrimidin-4(3H)-one containing various substituents at positions 5 and 6 of the pyrimidine ring were synthesized. It was shown that alkylation of 2-thiouracils with 1-bromo-2-(3,5-dimethylphenox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1861ee772663a73741bfa989af630c
https://doi.org/10.1023/b:cohc.0000023765.27571.40
https://doi.org/10.1023/b:cohc.0000023765.27571.40
Autor:
T C, McKee, J H, Cardellina, R, Riccio, M V, D'Auria, M, Iorizzi, L, Minale, R A, Moran, R J, Gulakowski, J B, McMahon, R W, Buckheit
Publikováno v:
Journal of Medicinal Chemistry. 37:793-797
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54180050801639aa3a5a82df97009fc3
https://doi.org/10.1021/jm00032a012
https://doi.org/10.1021/jm00032a012
Autor:
W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, J M Germany, J A Secrist, R Vince, W M Shannon
Publikováno v:
Journal of Biological Chemistry. 266:1754-1762
Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. Assays were developed to assess the mechanism of inhibition by the 5'-triphosphate of carbov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9af8f1c6457179ad5f8439b69df23f55
https://doi.org/10.1016/s0021-9258(18)52360-7
https://doi.org/10.1016/s0021-9258(18)52360-7
Publikováno v:
ChemInform. 37
The synthesis of novel 1-{[2-(phenoxy)ethoxy]methyl}uracil derivatives with different substituents in positions and 6 of the pyrimidine ring has been carried out. It has been shown that the alkylation of trimethylsilyl derivatives of uracil with 2-(4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b00aee17ec680e8aa2bd3d042e5442a
https://doi.org/10.1002/chin.200611215
https://doi.org/10.1002/chin.200611215
Autor:
B R, O'Keefe, T, Erim, J A, Beutler, J H, Cardellina, R J, Gulakowski, B L, Krepps, J B, McMahon, R C, Sowder, D G, Johnson, R W, Buckheit, S, Halliday, M R, Boyd
Publikováno v:
FEBS letters. 431(1)
Aqueous extracts of the New Zealand sponge Adocia sp. (Haplosclerida) displayed potent anticytopathic activity in CEM-SS cells infected with HIV-1. Protein fractions of the extract bound both to the viral coat protein gp120 and to the cellular recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b04f7332bdaee2a7afe820aa14953c79
https://pubmed.ncbi.nlm.nih.gov/9684871
https://pubmed.ncbi.nlm.nih.gov/9684871
Autor:
Stephen H. Hughes, M B Kroeger Smith, Paul L. Boyer, Koen Andries, Paul Adriaan Jan Janssen, Christopher J. Michejda, R W Buckheit, Ronald Smith
Publikováno v:
Protein engineering. 10(12)
A computer model of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) either alone, or complexed with a non-nucleoside inhibitor (NNI), was constructed using crystal coordinate data from a subset of the protein surrounding the bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06c2c4eee1188763dd2b0e57e2e05bd
https://pubmed.ncbi.nlm.nih.gov/9542999
https://pubmed.ncbi.nlm.nih.gov/9542999
Publikováno v:
Leukemia. 11
Oxathlin carboxanilide analogs (UC) and alpha APA, compounds recognized as nonnucleoside reverse transcriptase (RT) inhibitors (NNRTI), were evaluated for activity against the human immunodeficiency virus (HIV-1) and drug-resistant variants. These NN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4fe42112ad0d9193271d9f7315abf4d
https://pubmed.ncbi.nlm.nih.gov/9209308
https://pubmed.ncbi.nlm.nih.gov/9209308
Autor:
L Field, Catherine A. Schaeffer, R J Schultz, S Terpening, D. J. Clanton, P K Singh, D C Baker, Jim A. Turpin, R W Buckheit, J P Bader, M Bu, L Graham, William G. Rice
Publikováno v:
Antimicrobial agents and chemotherapy. 41(2)
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 protein contains two retrovirus-type zinc finger domains that are required for multiple phases of viral replication. Chelating residues (three Cys residues and one His residue) of the do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61a97e47efa532a7f9cde21143a9a79
https://pubmed.ncbi.nlm.nih.gov/9021201
https://pubmed.ncbi.nlm.nih.gov/9021201
Publikováno v:
Antiviral research. 33(2)
Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbca780ab6efbafd60f4d09601d211ec
https://pubmed.ncbi.nlm.nih.gov/9021050
https://pubmed.ncbi.nlm.nih.gov/9021050
Publikováno v:
Leukemia. 9
Current thrust in controlling the Acquired Immune Deficiency Syndrome (AIDS) focuses on antiviral drug development targeting the infection and replication of the human immunodeficiency virus (HIV), the causative agent of AIDS. To date, treatment of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b325db5a57638698d6d8d6530e0c333b
https://pubmed.ncbi.nlm.nih.gov/7475321
https://pubmed.ncbi.nlm.nih.gov/7475321