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Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein

Autor: G P Hough, Davis C. Drinkwater, Susan Hama, L. A. Ross, S. Imes, M Navab, Hillel Laks, Judith A. Berliner, R W Bork, A J Valente

Publikováno v: Journal of Clinical Investigation. 88:2039-2046

Incubation of cocultures of human aortic endothelial (HAEC) and smooth muscle cells (HASMC) with LDL in the presence of 5-10% human serum resulted in a 7.2-fold induction of mRNA for monocyte chemotactic protein 1 (MCP-1), a 2.5-fold increase in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d745cc07bd6ff0c33aa3e155b252a80
https://doi.org/10.1172/jci115532

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Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

Autor: D. R. Umbenhauer, P H Beaune, R S Lloyd, R W Bork, F P Guengerich

Publikováno v: Proceedings of the National Academy of Sciences. 83:8064-8068

Human liver cytochrome P-450NF is the form of cytochrome P-450 responsible for the oxidation of the calcium-channel blocker nifedipine, which has been reported to show polymorphism in clinical studies. By screening a bacteriophage lambda gt11 express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0b10c9654d03ddcf9f7b44d8912e65
https://doi.org/10.1073/pnas.83.21.8064

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Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

Autor: Nariko Shinriki, C. Ged, D. R. Umbenhauer, F. P. Guengerich, R W Bork, Pramod K. Srivastava, R S Lloyd, T. M. Bellew

Publikováno v: Biochemistry. 27:6929-6940

A cytochrome P-450 (P-450) multigene family codes for several related human liver enzymes, including the P-450 responsible for (S)-mephenytoin 4'-hydroxylation. This enzyme activity has previously been shown to be associated with a genetic polymorphi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d7659cec626fe67096cb5ee100b603
https://doi.org/10.1021/bi00418a039

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Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

Autor: R S Lloyd, T Muto, Pramod K. Srivastava, F. P. Guengerich, R W Bork, P H Beaune

Publikováno v: Journal of Biological Chemistry. 264:910-919

P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a bacteriophage λgt11 expression library, a cDNA clone designated NF 10 with an insert length of 2.8 kilobases (kb) was iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a37bb286c4d938f3d299ccaf90bc7aa
https://doi.org/10.1016/s0021-9258(19)85029-9

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Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

Autor: Ghazi A. Dannan, Martha V. Martin, P Churchill, D. R. Umbenhauer, Philippe H. Beaune, R W Bork, R. Stephen Lloyd, Robert G. Knodell, F. Peter Guengerich

Publikováno v: Biochemical Society Transactions. 15:576-578

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b3681b065fb091c4994ddc4bb582c7
https://doi.org/10.1042/bst0150576

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Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes

Autor: D. R. Umbenhauer, Pramod K. Srivastava, Teresa M. Bellew, F. Peter Guengerich, William Brian, R. Stephen Lloyd, R W Bork, Cecile Gedt

Publikováno v: Drug metabolism reviews. 20(2-4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9efeaa65458fe24110d2151fd33e6f2
https://pubmed.ncbi.nlm.nih.gov/2680390

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