Zobrazeno 1 - 10
of 59
pro vyhledávání: '"R W, Steger"'
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 87:176-182
The content of epinephrine (E), norepinephrine (NE) and dopamine (DA) was measured in the adrenals of male Snell dwarf mice, which are characterized by a genetically determined lack of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH), and i
Autor:
William J. Banz, Michael R. Peluso, R. W. Steger, Orsolya Mezei, Todd A. Winters, Neil F. Shay
Publikováno v:
The Journal of Nutrition. 133:1238-1243
The hypocholesterolemic and anti-atherosclerotic mechanism by which soy may exert a beneficial effect remains unclear. Peroxisome-proliferator activated receptors (PPAR) are promiscuous nuclear receptors that regulate the transcription of genes invol
Autor:
Andrzej Bartke, John J. Kopchick, Danyel R. Wernsing, Varadaraj Chandrashekar, Julie A. Mattison, Daniel Turyn, Natalia Danilovich, R. W. Steger, Luciano Debeljuk, Todd A. Winters, William Croson
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. 222:113-123
Transgenic mice overexpressing growth hormone (GH) exhibit alterations in the function of the hypothalamic-pituitary-gonadal (HPG) axis and the H-P-adrenal axis. Alterations in the turnover of hypo...
Autor:
June S. Yun, R. W. Steger, Thomas E. Wagner, Yunsheng Li, Xiao Z. Chen, John J. Kopchick, Andrzej Bartke
Publikováno v:
Transgenic Research. 7:61-71
In rodents, bovine (b) growth hormone (GH) binds only to GH receptors, while human (h) GH binds to both GH and PRL receptors. The phenotypic consequences of expression of bGH and hGH in transgenic mice are different and, in some cases, opposite. In t
Autor:
Andrzej Bartke, Varadaraj Chandrashekar, Daniel Turyn, R. W. Steger, Marcelo Cecim, Kechun Tang
Publikováno v:
Experimental Biology and Medicine. 206:345-359
Availability of recombinant growth hormone (GH) and development of long-acting formulations of this material will undoubtedly lead to widespread use of GH in animal industry and in medicine. GH can act, directly or indirectly, on multiple targets, bu
Autor:
Andrzej Bartke, Daniel Turyn, R. W. Steger, Claudio C. Aguilar, John J. Kopchick, Ana I. Sotelo, Xiao Z. Chen
Publikováno v:
Experimental Biology and Medicine. 206:190-194
Overexpression of human (h) or bovine (b) growth hormone (GH) in transgenic mice is associated with marked (2- to 12-fold) and significant increase in hepatic binding of GH and prolactin (PRL). This is due to an increase in the number of GH and PRL r
Autor:
R. W. Steger, Zhidong Chen
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 29:111-118
Microdialysis provides a means of continuous plasma sampling without repeated blood drawing. We report here the use of a specially designed and constructed microdialysis probe to sample plasma glucose, protein, and luteinizing hormone from the right
Publikováno v:
Life Sciences. 50:2037-2043
Cyclosporine (CyA) is extremely useful as an immunosuppressant and it is believed that at least some of its actions are due to antagonizing PRL effects. To determine whether the reported ability of CyA to inhibit gonadotropin release can be modified
Autor:
Kechun Tang, T.A. Parkening, R. W. Steger, T.J. Collins, Jun S. Yun, Andrzej Bartke, Thomas E. Wagner, Frances C. Buonomo
Publikováno v:
Neuroendocrinology. 53:365-372
The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations incl
Autor:
S. G. Kienast, R. W. Steger
Publikováno v:
Diabetes. 39:942-948
The ability of insulin replacement to reverse the adverse effects of streptozocin-induced diabetes (STZD) on neuroendocrine and sexual function was tested in adult male rats. Rats were injected with STZ (50 mg/kg) or vehicle and then either started i