Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R W, Niven"'
Publikováno v:
Pharmaceutical Research. 12:1889-1895
Purpose. The pulmonary pharmacokinetics and bioactivity of E. coli derived recombinant consensus interferon (CIFN) and a modified lactose-conjugated consensus interferon (LacCIFN) were evaluated in animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81beb2acdbd402c55ed1291a56ad4f7e
https://doi.org/10.1023/a:1016279503631
https://doi.org/10.1023/a:1016279503631
Publikováno v:
Pharmaceutical Research. 12:1343-1349
Purpose. The objective of this study was to highlight differences in the pulmonary absorption of a monoPEGylated rhG-CSF and rhG-CSF after intratracheal instillation and aerosol delivery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e48dd694c02af00c981f8d3b9408d11
https://doi.org/10.1023/a:1016281925554
https://doi.org/10.1023/a:1016281925554
Autor:
M. Kaltenbach, M. A. Myers, D. W. Soucy, Ricardo J. Gonzalez-Rothi, Hans Schreier, C. I. Hood, Leslie Straub, R. W. Niven, Dwayne A. Thomas
Publikováno v:
Experimental Lung Research. 19:1-19
Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e2a85e2f3aab5cb72ef8eb3cee4db0
https://doi.org/10.3109/01902149309071077
https://doi.org/10.3109/01902149309071077
Publikováno v:
Pharmaceutical research. 15(9)
To identify characteristics of lipid-DNA complexes that correlate with in vivo expression data.DOTIM:cholesterol liposomes (1:1 mole ratio) and DNA expressing chloramphenicol acetyl transferase (CAT) were complexed at a 4.2:1 mass ratio (cationic lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8aeaa9bead3d4459a920bededd18409
https://pubmed.ncbi.nlm.nih.gov/9755885
https://pubmed.ncbi.nlm.nih.gov/9755885
Autor:
D J, Freeman, R W, Niven
Publikováno v:
Pharmaceutical research. 13(2)
A plasmid containing the luciferase 'marker' cDNA was constructed to test non viral gene delivery formulations in vivo.A scale up procedure was devised to produce up to gram quantities of plasmid. Sufficient quantities were generated to process and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::747268ca8dc2c863352e1fabe77a56bf
https://pubmed.ncbi.nlm.nih.gov/8932437
https://pubmed.ncbi.nlm.nih.gov/8932437
Publikováno v:
Pharmaceutical research. 12(12)
The pulmonary pharmacokinetics and bioactivity of E. coli derived recombinant consensus interferon (CIFN) and a modified lactose-conjugated consensus interferon (LacCIFN) were evaluated in animals.Estimated doses of 20 and 100 micrograms/kg of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b1caea60f2da5b69098e14e5ad15099
https://pubmed.ncbi.nlm.nih.gov/8786962
https://pubmed.ncbi.nlm.nih.gov/8786962
Publikováno v:
Pharmaceutical research. 12(9)
The objective of this study was to highlight differences in the pulmonary absorption of a monoPEGylated rhG-CSF and rhG-CSF after intratracheal instillation and aerosol delivery.Male Sprague Dawley rats (250 g) were anesthetized and intratracheally i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bfddd1749fcde7d9f953f9d617b05c0
https://pubmed.ncbi.nlm.nih.gov/8570533
https://pubmed.ncbi.nlm.nih.gov/8570533
Publikováno v:
Pharmaceutical research. 12(1)
Ultrasonic nebulization of lactate dehydrogenase (LDH) was investigated using a DeVilbiss "Aerosonic" nebulizer. The enzyme (8ml, 0.025 mg/ml Na2HPO4, pH 7.0) was completely inactivated after 20 minutes of operation. However, the inactivation profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e327a6553d73fe480aed1f9cd3fe6a37
https://pubmed.ncbi.nlm.nih.gov/7724488
https://pubmed.ncbi.nlm.nih.gov/7724488
Publikováno v:
Pharmaceutical research. 11(8)
Two powder formulations (MMAD4 microns) containing rhG-CSF were insufflated (IF) via an endotracheal tube at doses of 5, 75 or 500 micrograms/kg to New Zealand white rabbits. Doses of 5 and 500 micrograms/kg of solutions were administered by intratra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0890193c7dfb0ac42f9b9c3db4119a2
https://pubmed.ncbi.nlm.nih.gov/7971709
https://pubmed.ncbi.nlm.nih.gov/7971709
Publikováno v:
Pharmaceutical research. 10(11)
Recombinant methionyl human granulocyte colony stimulating factor (G-CSF), a molecule of 18.8 kDa, has been shown to induce a systemic response after delivery by aerosol. In this work, rate and extent of absorption as well as the response were determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de30682de8cc29fdb5978b792ac17143
https://pubmed.ncbi.nlm.nih.gov/7507241
https://pubmed.ncbi.nlm.nih.gov/7507241