Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R W, Kozak"'
Publikováno v:
Blood. 80:2344-2352
We have previously shown that the variable domains of the monoclonal antibody anti-Tac [anti-Tac(Fv)] can be fused to derivatives of Pseudomonas exotoxin (PE) or diphtheria toxin (DT) to produce recombinant immunotoxins that kill interleukin-2 (IL-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77187b7de158c656a01a300ac7eabe0b
https://doi.org/10.1182/blood.v80.9.2344.bloodjournal8092344
https://doi.org/10.1182/blood.v80.9.2344.bloodjournal8092344
Publikováno v:
The Journal of Immunology. 148:63-71
The pattern of expression of receptors for insulin-like growth factors (IGF-I and IGF-II) and insulin was studied on monocyte-depleted human peripheral blood T cells activated via anti-CD3. Binding assays demonstrated the sequential appearance of rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6c81bd75892aa92b48959b3ae051ad
https://doi.org/10.4049/jimmunol.148.1.63
https://doi.org/10.4049/jimmunol.148.1.63
Autor:
R W Kozak, H Lorberboum-Galski, L Jones, R K Puri, M C Willingham, T Malek, D J Fitzgerald, T A Waldmann, I Pastan
Publikováno v:
The Journal of Immunology. 145:2766-2771
A number of different immunotherapeutic reagents are currently being developed to target IL-2R for the treatment of leukemia, graft rejection, and certain autoimmune diseases. Previously, we have shown that IL-2-PE40, a chimeric protein composed of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7ae3c7c1fb822d9c157366aba23ad6
https://doi.org/10.4049/jimmunol.145.8.2766
https://doi.org/10.4049/jimmunol.145.8.2766
Autor:
T K, Nikula, M R, McDevitt, R D, Finn, C, Wu, R W, Kozak, K, Garmestani, M W, Brechbiel, M J, Curcio, C G, Pippin, L, Tiffany-Jones, M W, Geerlings, C, Apostolidis, R, Molinet, O A, Gansow, D A, Scheinberg
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(1)
The alpha-particle-emitting radionuclides have several physical characteristics that make them attractive candidates for radioimmunotherapy: (a) high linear energy transfer; (b) short path lengths (50-80 microm); and (c) limited ability of cells to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a39d6ace035dc0448a7e18301ec6faa
https://pubmed.ncbi.nlm.nih.gov/9935073
https://pubmed.ncbi.nlm.nih.gov/9935073
Publikováno v:
Developments in biological standardization. 88
Several guidelines and recommendations have been published on assessing the potential risk of a biological product being contaminated with an agent causing a Transmissible Spongiform Encephalopathy (TSE). Basic principles which can be used during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfbd2b093dc701c275f2e22391488256
https://pubmed.ncbi.nlm.nih.gov/9119148
https://pubmed.ncbi.nlm.nih.gov/9119148
Autor:
F, Hartmann, E M, Horak, K, Garmestani, C, Wu, M W, Brechbiel, R W, Kozak, J, Tso, S A, Kosteiny, O A, Gansow, D L, Nelson
Publikováno v:
Cancer research. 54(16)
The efficacy, specificity, and toxicity of bismuth (212Bi) alpha particle-mediated radioimmunotherapy was evaluated in nude mice bearing a murine lymphoma transfected with the human CD25 [human Tac; interleukin 2 receptor alpha (IL-2R alpha)] gene. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c203f885dc7b3e396684be20935f0d2d
https://pubmed.ncbi.nlm.nih.gov/8044783
https://pubmed.ncbi.nlm.nih.gov/8044783
Publikováno v:
Cytotechnology. 9(1-3)
The Center for Biologics Evaluation and Research, whose regulatory authority includes monoclonal antibodies, cytokines, vaccines, toxins and somatic cellular therapies, communicates to sponsors issues for consideration in the development of biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96c3e25a523eb701e042aaaad7cdbf56
https://pubmed.ncbi.nlm.nih.gov/1369172
https://pubmed.ncbi.nlm.nih.gov/1369172
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(1)
The pattern of expression of receptors for insulin-like growth factors (IGF-I and IGF-II) and insulin was studied on monocyte-depleted human peripheral blood T cells activated via anti-CD3. Binding assays demonstrated the sequential appearance of rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::463a55edeaa8fa43f7940685d6c0f16d
https://pubmed.ncbi.nlm.nih.gov/1345791
https://pubmed.ncbi.nlm.nih.gov/1345791
Autor:
R W, Kozak
Publikováno v:
Developments in biological standardization. 76
Cell line characterization is an integral part of establishing quality control over the manufacturing process of a biological product. Characterizing the general and unique features of the continuous cell line and the absence or presence of contamina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c72ee76b7789464111e67315c96d0359
https://pubmed.ncbi.nlm.nih.gov/1478337
https://pubmed.ncbi.nlm.nih.gov/1478337
Autor:
R W, Kozak, D P, Fitzgerald, R W, Atcher, C K, Goldman, D L, Nelson, O A, Gansow, I, Pastan, T A, Waldmann
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(9)
The human allogeneic mixed lymphocyte reaction is the in vitro correlate of graft rejection. Cytotoxic effector cells generated during an allogeneic mixed lymphocyte reaction were previously shown to express the human p55 IL-2 receptor subunit, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7ab344b567f0a056baf61f2896db39d
https://pubmed.ncbi.nlm.nih.gov/2139454
https://pubmed.ncbi.nlm.nih.gov/2139454