Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R W, Kosley"'
Autor:
G M, Bores, F P, Huger, W, Petko, A E, Mutlib, F, Camacho, D K, Rush, D E, Selk, V, Wolf, R W, Kosley, L, Davis, H M, Vargas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer's disease; however, the therapeutic success of these compounds has been limited. Recently, another AChE inhibitor, galant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adbfcdf2868fbefad406fd3f2a33a8ca
https://pubmed.ncbi.nlm.nih.gov/8627552
https://pubmed.ncbi.nlm.nih.gov/8627552
Autor:
Y, Lebedinsky, S T, Nordstrom, S E, Aschoff, J F, Kapples, G J, O'Malley, R W, Kosley, S, Fielding, J W, Hubbard
Publikováno v:
Journal of cardiovascular pharmacology. 19(5)
Forskolin and milrinone both increase cyclic AMP concentrations to enhance cardiac contractility and cause vascular dilation in vitro and in vivo. However, forskolin acts via direct stimulation of adenylate cyclase while milrinone inhibits phosphodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1adfbc1bb46ce42a44ad12acb0f82ca
https://pubmed.ncbi.nlm.nih.gov/1381777
https://pubmed.ncbi.nlm.nih.gov/1381777
Autor:
J W, Hubbard, P G, Conway, L C, Nordstrom, H B, Hartman, Y, Lebedinsky, G J, O'Malley, R W, Kosley
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(2)
A series of in vitro studies were conducted examining the adenylate cyclase stimulation, positive chronotropic and inotropic effects of forskolin and nine analogs which exhibited a range of [3H]forskolin binding site affinities (K1) from 0.020 to 3.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b1618909afdc2edeba00d270ab52caa
https://pubmed.ncbi.nlm.nih.gov/1993999
https://pubmed.ncbi.nlm.nih.gov/1993999
Autor:
Harry M. Geyer, Gregory M. Shutske, S. Fielding, R. W. Kosley, J. C. Wilker, Michael Cornfeldt, Arthur R. McFadden, Richard C. Allen, Victor J. Bauer
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c0db0783f107f96e42f5f59d1dea5a
https://doi.org/10.1002/chin.197912245
https://doi.org/10.1002/chin.197912245
Autor:
V J, Bauer, B J, Duffy, D, Hoffman, S S, Klioze, R W, Kosley, A R, McFadden, L L, Martin, H H, Ong
Publikováno v:
Journal of medicinal chemistry. 19(11)
Synthesis of 1'-methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] (7a, HP 365) and the demethyl analogue 9a (HP 505) was prompted by recognition of an aminoalkyl(aryl)isobenzofuran moiety common to the antidepressants talopram (Lu 3-010) and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26bb5c27b8de2fb9a320686ce1dfbdb9
https://pubmed.ncbi.nlm.nih.gov/1003409
https://pubmed.ncbi.nlm.nih.gov/1003409
Autor:
R C, Allen, V J, Bauer, R W, Kosley, A R, McFadden, G M, Shutske, M L, Cornfeldt, S, Fielding, H M, Geyer, J C, Wilker
Publikováno v:
Journal of medicinal chemistry. 21(11)
The synthesis of 1'-[3-(4-fluorobenzyoyl)propyl]-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] (2a) and eight halo and methoxy analogues is described. The compounds were generally more potent per os than chlorpromazine in the Sidman avoidance para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248dc1ca87aad4a72509edca3a2c17a6
https://pubmed.ncbi.nlm.nih.gov/31478
https://pubmed.ncbi.nlm.nih.gov/31478