Výsledky vyhledávání - "R W, Hendren"

Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures

Autor: C.L. Stevenson, P F Augustijns, R W Hendren

Publikováno v: International Journal of Pharmaceutics. 177:103-115

The transepithelial transport of a synthetic peptide combinatorial library containing 375,000 individual peptides was assessed using Caco-2 cell monolayers in order to screen for permeability and deliverability. A series of 150 pools, each containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7226066f5ba7f98ec4987e0804942321
https://doi.org/10.1016/s0378-5173(98)00331-7

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Synthesis, properties, and biodegradation of poly(1,3-trimethylene carbonate)

Autor: R. W. Hendren, C. G. Pitt, K. J. Zhu, K. Jensen

Publikováno v: Macromolecules. 24:1736-1740

Poly(1,3-trimethylene carbonate) (PTMC) synthesized by diethylzinc-catalyzed ring-opening polymerization was characterized by its thermal and mechanical properties, permeability, and susceptibility to hydrolytic chain scission in vitro and in vivo. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::439231214fd39371a2a613c7f5311048
https://doi.org/10.1021/ma00008a008

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Genetic monitoring of inbred rodents from controlled production colonies through biochemical markers and skin grafting procedures

Autor: S P, Whitmore, A F, Gilliam, R W, Hendren, S E, Lewis, G N, Rao, C C, Whisnant

Publikováno v: Laboratory animal science. 46(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48e76221961da4c83206aa63467020ae
https://pubmed.ncbi.nlm.nih.gov/8905598

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A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA

Autor: Avinash Kothavale, R. W. Hendren, Richard W. Wagner, Jason Lewis, Kuei-Ying Lin, W. M. Flanagan, Robert A. Mook, Mark D. Matteucci, R. B. Deprince

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 93(8)

Development of antisense technology has focused in part on creating improved methods for delivering oligodeoxynucleotides (ODNs) to cells. In this report, we describe a cationic lipid that, when formulated with the fusogenic lipid dioleoylphosphatidy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc67ed86c2ae09caeaa9bd0cf14636b
https://pubmed.ncbi.nlm.nih.gov/8622909

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CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells

Autor: L S, Gan, M A, Moseley, B, Khosla, P F, Augustijns, T P, Bradshaw, R W, Hendren, D R, Thakker

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(3)

Transport of cyclosporin A (CsA) across Caco-2 cells is modulated by its directional efflux, mediated by a p-glycoprotein-like pump (Augustijns et al., Biochem. Biophys. Res. Comm. 197:360-365, 1994). In addition to this unidirectional flux, oxidativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a6b8d195dedc02559145d5f9fe3dc1f
https://pubmed.ncbi.nlm.nih.gov/8820426

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Matrix-assisted laser desorption mass spectrometric analysis of a pegylated recombinant protein

Autor: E, Watson, B, Shah, R, DePrince, R W, Hendren, R, Nelson

Publikováno v: BioTechniques. 16(2)

Matrix-assisted laser desorption ionization mass spectrometry (MALDI) has been investigated as a technique for the characterization of recombinant stem cell factor that had been covalently modified with polyethylene glycol (PEG) chains. The attachmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0a10caf50def8c38789a33ad1d7495b
https://pubmed.ncbi.nlm.nih.gov/7514005

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