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Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts

Autor: Susan J. Atkinson, John J. Reynolds, R V Ward, Gillian Murphy

Publikováno v: Biochemical Journal. 304:263-269

We report that the isolated C-terminal domain of progelatinase A is inhibitory to the activation of this proenzyme by primary skin fibroblast plasma membranes but is unable to inhibit organomercurial-induced self-cleavage and activation. Ligand bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d36ef15e85133b0648d2b81f9c5a65
https://doi.org/10.1042/bj3040263

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Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases

Autor: Gillian Murphy, Susan J. Atkinson, John J. Reynolds, R V Ward

Publikováno v: Biochemical Journal. 288:605-611

The ability of normal rabbit dermal fibroblasts to degrade films of type IV collagen and gelatin when stimulated by phorbol ester was shown to be dependent on the induction, secretion and activation of 95 kDa gelatinase B and the secretion and activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a7167cc16eba38c8976218f2f74551
https://doi.org/10.1042/bj2880605

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The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

Autor: Gillian Murphy, R V Ward, Di Eaton, Andrew J. P. Docherty, Mark I. Cockett, F. Willenbrock

Publikováno v: Biochemical Journal. 283:637-641

Recombinant 72 kDa gelatinase A and a truncated form lacking the C-terminal domain were shown to be activated by organomercurials and to possess similar activities towards a number of substrates. The truncated proenzyme differed from the full-length

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5592c55ec4761a04913a2db7c4ff436e
https://doi.org/10.1042/bj2830637

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Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

Autor: C W, Gray, R V, Ward, E, Karran, S, Turconi, A, Rowles, D, Viglienghi, C, Southan, A, Barton, K G, Fantom, A, West, J, Savopoulos, N J, Hassan, H, Clinkenbeard, C, Hanning, B, Amegadzie, J B, Davis, C, Dingwall, G P, Livi, C L, Creasy

Publikováno v: European journal of biochemistry. 267(18)

Human HtrA2 is a novel member of the HtrA serine protease family and shows extensive homology to the Escherichia coli HtrA genes that are essential for bacterial survival at high temperatures. HumHtrA2 is also homologous to human HtrA1, also known as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f55bf163198540f74dc833d5aed19622
https://pubmed.ncbi.nlm.nih.gov/10971580

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Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide

Autor: R V, Ward, K H, Jennings, R, Jepras, W, Neville, D E, Owen, J, Hawkins, G, Christie, J B, Davis, A, George, E H, Karran, D R, Howlett

Publikováno v: The Biochemical journal.

The beta-amyloid (Abeta) peptide, a major component of senile plaques in Alzheimer's disease brain, has been shown previously to undergo a process of polymerization to produce neurotoxic forms of amyloid. Recent literature has attempted to define pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afd482d2329eb6ae224a9e0bb4327040
https://pubmed.ncbi.nlm.nih.gov/10794724

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Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

Autor: Andrew J. P. Docherty, Gillian Murphy, R V Ward, Mark I. Cockett

Publikováno v: Biochemical Journal. 277:277-279

The abilities of the matrix metalloproteinases 95 kDa and 72 kDa gelatinases (type IV collagenases), stromelysins-1 and -2 and punctuated metalloproteinase (PUMP) to degrade insoluble elastin, type IV collagen films and proteoglycan have been compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ebf932abdb5675cae5b1e4b83b5241
https://doi.org/10.1042/bj2770277

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Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation

Autor: D R, Howlett, A R, George, D E, Owen, R V, Ward, R E, Markwell

Publikováno v: The Biochemical journal.

One of the major pathological features of Alzheimer's disease is the deposition of beta-amyloid peptide (Abeta). Cellular toxicity has been shown to be associated with fibrillar forms of Abeta; preventing this fibril formation is therefore viewed as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fff331ed3a06bd2f6a869c397e3ba0f
https://pubmed.ncbi.nlm.nih.gov/10510309

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