Výsledky vyhledávání - "R U, Jänicke"

Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin-cAMP pathway

Autor: S, Twarock, K, Röck, M, Sarbia, A A, Weber, R U, Jänicke, J W, Fischer

Publikováno v: British journal of pharmacology. 157(2)

Cyclooxygenase-2 (COX2) and hyaluronic acid (HA) are common in tumours and both independently promote tumour progression. Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffec646f943a69dd407d40dad9e51146
https://pubmed.ncbi.nlm.nih.gov/19338584

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Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells

Autor: C, Blanc, Q L, Deveraux, S, Krajewski, R U, Jänicke, A G, Porter, J C, Reed, R, Jaggi, A, Marti

Publikováno v: Cancer research. 60(16)

In this study, we sought to investigate in more detail the role of caspase-3 in apoptotic processes in cultured cells and in cell-free extracts of breast cancer cells. We present evidence that apoptosis of caspase-3-deficient MCF-7 breast cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7970d7f640d7c2c8632d4e092437dce
https://pubmed.ncbi.nlm.nih.gov/10969782

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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7

Autor: X, Yang, H R, Stennicke, B, Wang, D R, Green, R U, Jänicke, A, Srinivasan, P, Seth, G S, Salvesen, C J, Froelich

Publikováno v: The Journal of biological chemistry. 273(51)

Granzyme B (GrB) is predicted to trigger apoptosis by activating preferred caspases, but the zymogens that are directly processed by the granzyme and the requirements for these interactions remain unclarified. We examined this dilemma by comparing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5a2793d6f52328dcde70af2f5e685f0
https://pubmed.ncbi.nlm.nih.gov/9852092

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Death substrates come alive

Autor: A G, Porter, P, Ng, R U, Jänicke

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology. 19(6)

Interleukin 1 beta-converting enzyme (ICE)-like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01ead8a29b5972235ab62ae23bcdb874
https://pubmed.ncbi.nlm.nih.gov/9204767

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