Zobrazeno 1 - 10
of 71
pro vyhledávání: '"R Thomas Lumbers"'
Autor:
Yang Chen, Anoop Shah, Folkert W Asselbergs, R Thomas Lumbers, Daniel Higgins, Yogini Jani, Nausheen Saleem, Kris Chafer, Matthew Robert Sydes
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Introduction Acute heart failure (HF) is a major cause of unplanned hospitalisation characterised by excess body water. A restriction in oral fluid intake is commonly imposed on patients as an adjunct to pharmacological therapy with loop diuretics, b
Externí odkaz:
https://doaj.org/article/6675c522fe83485c843db2ae55065e9b
Autor:
Sam Hodgson, Qin Qin Huang, Neneh Sallah, Genes & Health Research Team, Chris J Griffiths, William G Newman, Richard C Trembath, John Wright, R Thomas Lumbers, Karoline Kuchenbaecker, David A van Heel, Rohini Mathur, Hilary C Martin, Sarah Finer
Publikováno v:
PLoS Medicine, Vol 19, Iss 5, p e1003981 (2022)
BackgroundType 2 diabetes (T2D) is highly prevalent in British South Asians, yet they are underrepresented in research. Genes & Health (G&H) is a large, population study of British Pakistanis and Bangladeshis (BPB) comprising genomic and routine heal
Externí odkaz:
https://doaj.org/article/62845c8652514e528a945b09500a0c31
Autor:
Marc-André Legault, Johanna Sandoval, Sylvie Provost, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Sonia Shah, R Thomas Lumbers, Simon de Denus, Benoit Tyl, Jean-Claude Tardif, Marie-Pierre Dubé
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236193 (2020)
BackgroundNaturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure despite i
Externí odkaz:
https://doaj.org/article/52a9a7b767ca4bfc96f14048d78d9942
Autor:
Valerie Kuan, MBBS, Spiros Denaxas, PhD, Arturo Gonzalez-Izquierdo, PhD, Kenan Direk, PhD, Osman Bhatti, FRCGP, Shanaz Husain, MBBS, Shailen Sutaria, FFPH, Melanie Hingorani, FRCOphth, Dorothea Nitsch, ProfMD, Constantinos A Parisinos, MRCP, R Thomas Lumbers, PhD, Rohini Mathur, PhD, Reecha Sofat, PhD, Juan P Casas, ProfPhD, Ian C K Wong, ProfPhD, Harry Hemingway, ProfFFPH FRCP, Aroon D Hingorani, ProfPhD
Publikováno v:
The Lancet: Digital Health, Vol 1, Iss 2, Pp e63-e77 (2019)
Summary: Background: To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know which sections of the population are susceptible to which health condi
Externí odkaz:
https://doaj.org/article/e5b06d849205495190a8a2bda5d4673a
Autor:
Maria-Carolina Borges, Phillip Haycock, Jie Zheng, Gibran Hemani, Laurence J Howe, A Floriaan Schmidt, James R Staley, R Thomas Lumbers, Albert Henry, Rozenn N Lemaitre, Tom R Gaunt, Michael V Holmes, George Davey Smith, Aroon D Hingorani, Deborah A Lawlor
Publikováno v:
Borges, M C, Haycock, P C, Zheng, J, Hemani, G, Howe, L J M S, Schmidt, A F, Staley, J R, Lumbers, R T, Henry, A, Lemaitre, R N, Gaunt, T R, Holmes, M V, Davey Smith, G, Hingorani, A & Lawlor, D A 2022, ' The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians : A Mendelian randomization study ', Human Molecular Genetics, vol. 31, no. 23, ddac153, pp. 4034-4054 . https://doi.org/10.1093/hmg/ddac153
Despite early interest, the evidence linking fatty acids to cardiovascular diseases remains controversial. We used Mendelian randomization to explore the involvement of polyunsaturated (PUFA) and monounsaturated (MUFA) fatty acids biosynthesis in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf682c1691b6898a34e0463f065fd39b
https://research-information.bris.ac.uk/en/publications/4e43c5d3-3af6-462d-aaa6-8e194ec51bf2
https://research-information.bris.ac.uk/en/publications/4e43c5d3-3af6-462d-aaa6-8e194ec51bf2
Autor:
Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Caroline E. Baker, Yoshihiko Kobayashi, Svati H. Shah, Christopher D. Kontos, Purushothama Rao Tata, R. Thomas Lumbers, Ravi Karra
Publikováno v:
Development. 149
Heart regeneration requires multiple cell types to enable cardiomyocyte (CM) proliferation. How these cells interact to create growth niches is unclear. Here, we profile proliferation kinetics of cardiac endothelial cells (CECs) and CMs in the neonat
Autor:
Qin Qin Huang, Neneh Sallah, Diana Dunca, Bhavi Trivedi, Karen A. Hunt, Sam Hodgson, Samuel A. Lambert, Elena Arciero, John Wright, Chris Griffiths, Richard C. Trembath, Harry Hemingway, Michael Inouye, Sarah Finer, David A. van Heel, R. Thomas Lumbers, Hilary C. Martin, Karoline Kuchenbaecker
Publikováno v:
Nature Communications
Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data from 22,000 British Pakistani and Bangladeshi individuals with linked electronic health recor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec3eb38dae236b091a3728f73c62d69
Autor:
Spiros Denaxas, Johanna Mielke, Suliang Chen, Amitava Banerjee, Dipak Kotecha, Mohamad Zeina, Harry Hemingway, Ghazaleh Fatemifar, Simrat Gill, Daniel F. Freitag, R. Thomas Lumbers
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
BMC Medicine
BMC Medicine
Background Machine learning (ML) is increasingly used in research for subtype definition and risk prediction, particularly in cardiovascular diseases. No existing ML models are routinely used for cardiovascular disease management, and their phase of
Autor:
Musaab Elkheder, Arturo Gonzalez-Izquierdo, Muhammad Qummer Ul Arfeen, Valerie Kuan, R Thomas Lumbers, Spiros Denaxas, Anoop D Shah
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA.
Objective Patient phenotype definitions based on terminologies are required for the computational use of electronic health records. Within UK primary care research databases, such definitions have typically been represented as flat lists of Read term
Autor:
Marjola Thanaj, Johanna Mielke, Kathryn A. McGurk, Wenjia Bai, Nicolò Savioli, Antonio de Marvao, Hannah V. Meyer, Lingyao Zeng, Florian Sohler, R. Thomas Lumbers, Martin R. Wilkins, James S. Ware, Christian Bender, Daniel Rueckert, Aidan MacNamara, Daniel F. Freitag, Declan P. O’Regan
Diastole is the sequence of physiological events that occur in the heart during ventricular filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal diastolic function is related to many cardiovascular disease processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee0dc54ca8ad7e41f99f5a09efce53c
http://hdl.handle.net/10044/1/95815
http://hdl.handle.net/10044/1/95815