Zobrazeno 1 - 10
of 180
pro vyhledávání: '"R Tarjan"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and
Externí odkaz:
https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa5645
Autor:
Russell J.H. Ryan, Jelena Petrovic, Dylan M. Rausch, Yeqiao Zhou, Caleb A. Lareau, Michael J. Kluk, Amanda L. Christie, Winston Y. Lee, Daniel R. Tarjan, Bingqian Guo, Laura K.H. Donohue, Shawn M. Gillespie, Valentina Nardi, Ephraim P. Hochberg, Stephen C. Blacklow, David M. Weinstock, Robert B. Faryabi, Bradley E. Bernstein, Jon C. Aster, Warren S. Pear
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 784-797 (2017)
Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. We perfor
Externí odkaz:
https://doaj.org/article/38f5e0dad5ea46838f521f8dde4cb919
Autor:
Jeffrey M Skerker, Dacia Leon, Morgan N Price, Jordan S Mar, Daniel R Tarjan, Kelly M Wetmore, Adam M Deutschbauer, Jason K Baumohl, Stefan Bauer, Ana B Ibáñez, Valerie D Mitchell, Cindy H Wu, Ping Hu, Terry Hazen, Adam P Arkin
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-21 (2013)
Abstract The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material. Unfortunately, plant hydrolysates also contain many compounds that inhibit microbial growth a
Externí odkaz:
https://doaj.org/article/5b27a545429d4b08976dc36c2769d249
Autor:
Nauman M. Javed, Jason L. Hornick, Ewa Sicinska, Bradley E. Bernstein, Prafulla C. Gokhale, Benjamin K. Eschle, George D. Demetri, Esmat Hegazi, Matthew L. Hemming, Daniel R. Tarjan, Chandrajit P. Raut, Yotam Drier, Sarah J. Shareef, William A. Flavahan, Sarah E. Johnstone
Publikováno v:
Nature
Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1–3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e025a723c36f280f5610b300e74df6
https://doi.org/10.1038/s41586-019-1668-3
https://doi.org/10.1038/s41586-019-1668-3
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Nature Communications
Nature Communications
The human genome is folded into regulatory units termed ‘topologically-associated domains’ (TADs). Genome-wide studies support a global role for the insulator protein CTCF in mediating chromosomal looping and the topological constraint of TAD bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f69a84ce53e1dcc761e5ec5ecea0fd6
https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa5645
https://doaj.org/article/a3ca68a0d6b24effa3df235e4cfa5645
Autor:
Sangwon Lee, Jil T Geller, Tamas Torok, Cindy H Wu, Mary Singer, Francine C Reid, Daniel R Tarjan, Terry C Hazen, Adam P Arkin, Nathan J Hillson
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105689 (2014)
We are developing a laboratory-scale model to improve our understanding and capacity to assess the biological risks of genetically engineered bacteria and their genetic elements in the natural environment. Our hypothetical scenario concerns an indust
Externí odkaz:
https://doaj.org/article/e09666aeee9e4c86bb42fe3a6f7a80f6
Autor:
Caleb A. Lareau, Robert B. Faryabi, Yeqiao Zhou, Russell J.H. Ryan, Laura Donohue, Amanda L. Christie, David M. Weinstock, Michael J. Kluk, Winston Y. Lee, Shawn M. Gillespie, Jelena Petrovic, Ephraim P. Hochberg, Bingqian Guo, Warren S. Pear, Bradley E. Bernstein, Dylan M. Rausch, Daniel R. Tarjan, Stephen C. Blacklow, Jon C. Aster, Valentina Nardi
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 784-797 (2017)
Summary Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c7d173cc05e777303001dd655c4911
https://doi.org/10.1016/j.celrep.2017.09.066
https://doi.org/10.1016/j.celrep.2017.09.066
Autor:
George D. Demetri, Bradley E. Bernstein, Daniel R. Tarjan, Yotam Drier, Matthew L. Hemming, Chandrajit P. Raut, William A. Flavahan, Esmat Hegazi, Sarah E. Johnstone, Jason L. Hornick, Ewa Sicinska
Publikováno v:
Cancer Research. 78:2996-2996
Metabolic lesions with profound effects on epigenetic regulation are widely implicated in cancer, yet the mechanistic links between this epigenetic dysregulation and tumorigenesis remain unclear. Succinate dehydrogenase (SDH) deficiency, responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91779c0d690c93e948c9eb1fd650e714
https://doi.org/10.1158/1538-7445.am2018-2996
https://doi.org/10.1158/1538-7445.am2018-2996
Autor:
A. Hendrikx, J. E. Dutra de Oliveira, T. N. Maletnlema, M. Vannucchi, E. Morava, W. A. Krehl, H. D. Cremer, F. Fidanza, K. Bagchi, R. Tarjan, A. Valyasevi, Naiara Wiggers de Souza, K. B. Taylor, J. S. Ju, E. Sarakikya, E. F. P. Jelliffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25519c83bdd53cc03d40060ba7f9bea0
https://doi.org/10.1159/000403219
https://doi.org/10.1159/000403219
Autor:
Wenjun Shao, Kelly M. Wetmore, Dacia Leon, Daniel R. Tarjan, Adam P. Arkin, Jeffrey M. Skerker, Zhuchen Xu, Adam M. Deutschbauer, Morgan N. Price
Publikováno v:
Journal of bacteriology, vol 196, iss 20
Mutant phenotypes provide strong clues to the functions of the underlying genes and could allow annotation of the millions of sequenced yet uncharacterized bacterial genes. However, it is not known how many genes have a phenotype under laboratory con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557e6094ebbc325d01f1cccd44744a1c
https://escholarship.org/uc/item/78s6x9q5
https://escholarship.org/uc/item/78s6x9q5