Výsledky vyhledávání - "R T Streeper"

In vitro metabolic transformations of 2,4-dipyrrolidinylpyrimidine: a chemical probe for P450-mediated oxidation of tirilazad mesylate

Autor: J J Vrbanac, Paul G. Pearson, P E Sanders, R T Streeper, Larry C. Wienkers, Z Zhao, S A Mizsak

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(11)

1. We have determined that 2,4-dipyrrolidinylpyrimidine (2,4-DPP), used as a model for studies of the metabolism of therapeutic agents containing this moiety, undergoes three characteristic hydroxylations when incubated with male rat liver microsomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7e5de145c917fb5c7f6cdeb5438c52
https://pubmed.ncbi.nlm.nih.gov/9413917

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Molecular pharmacology of hepsulfam, NSC 3296801: identification of alkylated nucleosides, alkylation site, and site of DNA cross-linking

Autor: R T, Streeper, R J, Cotter, M E, Colvin, J, Hilton, O M, Colvin

Publikováno v: Cancer research. 55(7)

We have determined that hepsulfam, in common with its structural homologue busulfan, alkylates both free guanosine and GMP in DNA at the 7 nitrogen. Mass spectral analysis of the products of the reaction of hepsulfam with guanosine has identified the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e6cf3550837614710487915e129a45f
https://pubmed.ncbi.nlm.nih.gov/7882358

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Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione

Autor: M G, Bolton, J, Hilton, K D, Robertson, R T, Streeper, O M, Colvin, D A, Noe

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(6)

The reaction kinetics of the hydrolysis, phosphatolysis, glutathionyl conjugation, and alpha-glutathione-S-transferase (GST)-catalyzed glutathione conjugation of [3H-ring]melphalan were investigated at pH 6.5 and 7.4. The distribution of products rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28f5711e7cdc11a57df8b8fbe6b239e2
https://pubmed.ncbi.nlm.nih.gov/7905404

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Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance

Autor: D K, Armstrong, G B, Gordon, J, Hilton, R T, Streeper, O M, Colvin, N E, Davidson

Publikováno v: Cancer research. 52(6)

Hepsulfam (NSC 329680, 1,7-heptanediol disulfamate) is an alkylating agent that showed excellent activity against mouse and human mammary carcinoma in preclinical studies. We therefore studied the cytotoxicity of this drug in six human breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a1b0262c83f33553ff631f4fca08ee6
https://pubmed.ncbi.nlm.nih.gov/1540950

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