Zobrazeno 1 - 10
of 49
pro vyhledávání: '"R T Okita"'
Autor:
David S. Wunschel, Janice Rice Okita, Robert J. Edwards, Amy L. Kimzey, Hyesook Kim, Richard C. Zangar, R. T. Okita
Publikováno v:
Molecular Pharmacology. 61:892-904
We characterize a novel microsome system that forms high-molecular-mass (HMM) CYP3A, CYP2E1, and ubiquitin conjugates, but does not alter CYP4A or most other microsomal proteins. The formation of the HMM bands was observed in hepatic microsomes isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67c6ead312ccd838dc9da563d8b1f96
https://doi.org/10.1124/mol.61.4.892
https://doi.org/10.1124/mol.61.4.892
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 46:93-98
The specific activity of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) was found to increase in the ovaries of pregnant and pseudopregnant rabbits. The mean specific activity of cytosolic ovarian PGDH in 14- to 28-day pregnant rabbits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbed25708813c1e59c716cdab3213aa7
https://doi.org/10.1016/0952-3278(92)90214-4
https://doi.org/10.1016/0952-3278(92)90214-4
Publikováno v:
Journal of Biological Chemistry. 265:14888-14891
NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase catalyzes the oxidation of many prostaglandins at C-15, resulting in a subsequent reduction in their biological activity. We report the isolation of the cDNA for this enzyme. A human placental la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1492c21d49f077f74758664aaf7ca5d5
https://doi.org/10.1016/s0021-9258(18)77199-8
https://doi.org/10.1016/s0021-9258(18)77199-8
Autor:
Jo Bergholte, R. T. Okita, Janice Rice Okita, Allan R. Sinning, Roger R. Markwald, Hsin-Hsiung Tai
Publikováno v:
Archives of Biochemistry and Biophysics. 279:242-248
A polyclonal antibody was produced in guinea pig against the lung NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) purified from pregnant rabbits. Western blot analysis demonstrated that the protein identified by this antibody in the 105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab684280dd20f519849e5b9def38b7c9
https://doi.org/10.1016/0003-9861(90)90488-k
https://doi.org/10.1016/0003-9861(90)90488-k
Publikováno v:
Textbook of Biochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c5c22a6121d315156538921166eb77
https://doi.org/10.1002/0471254959.dev011
https://doi.org/10.1002/0471254959.dev011
Autor:
R C, Zangar, J R, Okita, H, Kim, P E, Thomas, A, Anderson, R J, Edwards, D L, Springer, R T, Okita
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Calcium channel antagonists are widely prescribed for treatment of hypertension. In this study, we examined whether treatment with the calcium channel antagonists, nicardipine, nifedipine or diltiazem, alters cytochrome P-450 2B or 3A (CYP2B or CYP3A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46d2483f63881e57d3819a3a038fc6a5
https://pubmed.ncbi.nlm.nih.gov/10454523
https://pubmed.ncbi.nlm.nih.gov/10454523
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(8)
In the study of tissues that contain several forms of one cytochrome P450 subfamily, it is useful to develop immunoblotting techniques so that the various individual members of the family can be distinguished. This paper describes improvements in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e216409c648867190f913c5c32af56ba
https://pubmed.ncbi.nlm.nih.gov/9280410
https://pubmed.ncbi.nlm.nih.gov/9280410
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(2)
Lauramide diethanolamine (LDEA)--a compound used in cosmetics and soap products as an emollient, thickener, and foam stabilizer--was observed to be metabolized by rat liver microsomes to two major products that were identified by GC/MS to be the 11-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33011d0b205d5654245daa40574772fb
https://pubmed.ncbi.nlm.nih.gov/8742229
https://pubmed.ncbi.nlm.nih.gov/8742229
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(10)
Nine male and five female human liver microsomal sample were examined for laurate 11- and 12-hydroxylase activities. The mean specific activities for the 11- and 12-hydroxylation reactions were 0.78 +/- 0.33 and 1.07 +/- 0.12 nmol/min/mg protein, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d699b48b4b1c775d7fc2bfde6652b4e
https://pubmed.ncbi.nlm.nih.gov/8654190
https://pubmed.ncbi.nlm.nih.gov/8654190
Effects of diethyl phthalate and other plasticizers on laurate hydroxylation in rat liver microsomes
Autor:
R T, Okita, J R, Okita
Publikováno v:
Pharmaceutical research. 9(12)
Diethyl phthalate (DEP) is used in pharmaceutical coatings, cosmetics, and plastic films to wrap foods. There is a health concern associated with the exposure to certain phthalate esters because they belong to a class of compounds referred to as pero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9fe50cb69dc667cd7dc6e19af38c84a
https://pubmed.ncbi.nlm.nih.gov/1488412
https://pubmed.ncbi.nlm.nih.gov/1488412