Zobrazeno 1 - 9
of 9
pro vyhledávání: '"R T McConnell"'
Publikováno v:
Molecular pharmacology. 47(6)
Many functions of the immune and inflammatory responses are inhibited by agents that increase intracellular levels of cAMP. Recent investigations have revealed that cAMP levels in inflammatory cells are regulated by cyclic nucleotide phosphodiesteras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd2fd221fe8eb2198a1c28c6eac5a614
https://pubmed.ncbi.nlm.nih.gov/7603456
https://pubmed.ncbi.nlm.nih.gov/7603456
Autor:
M W, Verghese, R T, McConnell, A B, Strickland, R C, Gooding, S A, Stimpson, D P, Yarnall, J D, Taylor, P J, Furdon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(3)
Elevation of cAMP downregulates certain functions of inflammatory cells, including the release of TNF alpha and IL-1 beta by macrophages. Intracellular cAMP levels can be modulated pharmacologically by adding cell-permeable cAMP analogs, by stimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a47a53fe5bcecc711b3b71735379763f
https://pubmed.ncbi.nlm.nih.gov/7891349
https://pubmed.ncbi.nlm.nih.gov/7891349
Publikováno v:
Journal of Biological Chemistry. 263:9285-9291
The mechanism of transport of the antiviral agent acyclovir (ACV) into human erythrocytes has been investigated. Initial velocities of ACV influx were determined with an "inhibitor-stop" assay that used papaverine to inhibit ACV influx rapidly and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee37a4ac8a19a905a1957c75e088cd9
https://doi.org/10.1016/s0021-9258(19)76537-5
https://doi.org/10.1016/s0021-9258(19)76537-5
Publikováno v:
Journal of Biological Chemistry. 259:13199-13203
The biochemical events underlying the ability of thrombin to enhance the metabolism of inositol phospholipids in human platelets have been investigated using platelets prelabeled with [3H]inositol. Thrombin treatment caused rapid formation of radioac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0849384293bcf98d064e6fa21791af
https://doi.org/10.1016/s0021-9258(18)90677-0
https://doi.org/10.1016/s0021-9258(18)90677-0
Publikováno v:
Biochemical Journal. 226:831-837
The present study investigates the pathway of metabolism of inositol phospholipids in human platelets exposed to collagen. Platelet activation by collagen was preceded by a lag phase usually lasting 10-20 s. Formation of [3H]inositol trisphosphate (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312c94ac3e4f59df882b7e0ef457f769
https://doi.org/10.1042/bj2260831
https://doi.org/10.1042/bj2260831
Publikováno v:
Biochemical Journal. 232:61-66
Platelets rapidly convert 1,2-didecanoyl-sn-glycerol into its corresponding phosphatidic acid and lysophosphatidic acid derivatives, thereby providing a means of introducing these two compounds into platelets. 1-Decanoyl-2-lyso-3-sn-phosphatidic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef0305cfcb829cab46146da4477a6ba
https://doi.org/10.1042/bj2320061
https://doi.org/10.1042/bj2320061
Publikováno v:
The Journal of biological chemistry. 263(19)
The mechanism of transport of the antiviral agent acyclovir (ACV) into human erythrocytes has been investigated. Initial velocities of ACV influx were determined with an "inhibitor-stop" assay that used papaverine to inhibit ACV influx rapidly and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1286127d2cad389347fa81c63e2b3bbf
https://pubmed.ncbi.nlm.nih.gov/3379070
https://pubmed.ncbi.nlm.nih.gov/3379070
Autor:
M. I. Siegel, R. T. McConnell, N. A. Porter, J. L. Selph, J. E. Truax, R. Vinegar, P. Cuatrecasas
Publikováno v:
Inflammation: Mechanisms and Treatment ISBN: 9789401094252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de1724f11642a0a90a91b9c8c093c88
https://doi.org/10.1007/978-94-010-9423-8_36
https://doi.org/10.1007/978-94-010-9423-8_36
Publikováno v:
Molecular pharmacology. 21(3)
Neutrophils isolated from the pleural cavity of rats 3 hr after the intrapleural injection of carrageenan metabolize exogenously added arachidonic acid via cyclooxygenase and lipoxygenase. In addition, these cells esterify arachidonic acid to produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c4f83fda87885bd5d3c0c678ada7fd6
https://pubmed.ncbi.nlm.nih.gov/6810089
https://pubmed.ncbi.nlm.nih.gov/6810089