Zobrazeno 1 - 10
of 58
pro vyhledávání: '"R T Holzbach"'
Autor:
G Yamashita, S Ginanni Corradini, R Secknus, A Takabayashi, C Williams, L Hays, A L Chernosky, R T Holzbach
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 6, Pp 1325-1333 (1995)
BACKGROUND/AIMS: Several proteins present in human bile have been reported to promote cholesterol crystallization and thus are potentially important in the formation of cholesterol crystals as the initial stage in gallstone pathogenesis. To be physio
Externí odkaz:
https://doaj.org/article/a12d82e80aba4db6bfcebfc2ea795139
Publikováno v:
Journal of Lipid Research, Vol 26, Iss 9, Pp 1102-1111 (1985)
We explored the influence of several compositional factors considered capable of influencing the nucleation time of model biles supersaturated in cholesterol. In addition to the classical techniques, e.g., electron microscopy and quasielastic light s
Externí odkaz:
https://doaj.org/article/4a59bc34ebec45f49a9f84dcd74bef4e
Publikováno v:
Journal of Lipid Research, Vol 27, Iss 3, Pp 295-306 (1987)
The presence of small vesicles composed of phospholipid and cholesterol has recently been demonstrated in super-saturated model and in dilute native human biles by several groups using differing methods. Among compositional factors shown to favor spo
Externí odkaz:
https://doaj.org/article/4ea0551a5c904ae399621b9f09d80b38
Publikováno v:
Journal of Gastroenterology and Hepatology. 11:738-745
Several proteins are known to modulate cholesterol crystallization. We recently demonstrated that haptoglobin has cholesterol crystallization promoting activity. However, this effect is still not well understood mechanistically. The current study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320cf5370eae2cf0350bcdb851ba3c58
https://doi.org/10.1111/j.1440-1746.1996.tb00324.x
https://doi.org/10.1111/j.1440-1746.1996.tb00324.x
Autor:
P. K. Kawczak, R T Holzbach, Jörg Schwarzendrube, Masato Abei, C. Williams, T. A. Broughan, H. Nuutinen
Publikováno v:
Journal of Lipid Research, Vol 34, Iss 7, Pp 1141-1148 (1993)
Concanavalin A (Con A)-binding glycoproteins accelerate the rate of cholesterol crystal formation as a prelude to gallstone formation. Immunoglobulins (IgM, IgA, and IgG), aminopeptidase N (APN), phospholipase C (pcPLC), and alpha 1-acid glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f84d5b97678405449f812a8858aab5
http://www.sciencedirect.com/science/article/pii/S0022227520377014
http://www.sciencedirect.com/science/article/pii/S0022227520377014
Publikováno v:
Journal of Lipid Research, Vol 32, Iss 4, Pp 695-702 (1991)
Pooled, normal human gallbladder biles were initially separated on a molecular sieving chromatography column to remove soluble mucin glycoproteins as well as high molecular weight proteins (greater than 200,000). The remaining lower molecular weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f7fd85a3fcb4e8de9c5904956b8e88
https://doi.org/10.1016/s0022-2275(20)42057-7
https://doi.org/10.1016/s0022-2275(20)42057-7
Autor:
N Busch, R T Holzbach
Publikováno v:
Gastroenterology Clinics of North America. 20:67-84
Among the factors affecting the stability of supersaturated bile that culminates in the nucleation and growth of cholesterol crystals are biliary lipids. The abundance and composition of these lipids affect the composition of biliary vesicles that, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3670fe1df15857254729584c0364504d
https://doi.org/10.1016/s0889-8553(21)00534-3
https://doi.org/10.1016/s0889-8553(21)00534-3
Publikováno v:
Journal of gastroenterology and hepatology. 14(5)
Apolipoprotein A-I (Apo A-I), conventionally purified by several steps including organic solvent-delipidation from plasma, inhibits cholesterol crystallization in bile. To observe a significant effect in vitro, however, supraphysiological concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8bafa67264a1a9dcec4d942d3bcdde4
https://pubmed.ncbi.nlm.nih.gov/10355509
https://pubmed.ncbi.nlm.nih.gov/10355509
Autor:
R, Secknus, R T, Holzbach
Publikováno v:
Zeitschrift fur Gastroenterologie. 35(1)
Cholelithiasis is a frequent disease in developed countries with significant economical implications. While the multifactorial pathogenesis of cholesterol gallstones has been widely accepted, the relative importance of the various contributing factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56bd17e2356845176b7002a479c30c2a
https://pubmed.ncbi.nlm.nih.gov/9123957
https://pubmed.ncbi.nlm.nih.gov/9123957
Autor:
M.-A. Secknus, R T Holzbach, R. Secknus, G. Yamashita, S. Ginanni Corradini, Ann Chernosky, L. Hays, C. Williams
Publikováno v:
Scopus-Elsevier
Crystallization-inhibiting proteins can explain longer nucleation times associated with bile from gallstone-free subjects as compared with bile from patients with cholesterol gallstones. We partially characterized and examined the crystallization inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d926d8016b15633427b0d8a84b3ce89a
http://hdl.handle.net/11573/107995
http://hdl.handle.net/11573/107995
