Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R T, Stravitz"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 12, Pp 2483-2491 (1997)
In primary cultures of rat hepatocytes, transcription of the cholesterol 7alpha-hydroxylase gene is induced synergistically by glucocorticoid and thyroid hormones. The objective of the present study was to evaluate the role of endogenous glucocortico
Externí odkaz:
https://doaj.org/article/07fadeb554a8476c893d58444424d6b5
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 12, Pp 2446-2454 (1997)
The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. To determine whether bile acids could activate PKC indirectly via generatio
Externí odkaz:
https://doaj.org/article/834e6267283645e9871a33373a71f4bd
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 6, Pp 1359-1369 (1995)
Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes. The addition of taurocholate (25 microM) for 6 h decreased cho
Externí odkaz:
https://doaj.org/article/7744bbdcc70544dfb899534631550d8d
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 2, Pp 239-247 (1994)
In the bile acid biosynthetic pathways of humans and the rat, hepatic 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSDH) catalyzes the stereospecific reduction of the 3-oxo group of bile acid precursors. In addition, 3 alpha-HSDH may serve to shuttl
Externí odkaz:
https://doaj.org/article/80c698880ed3496dbac6c584b8aa8b79
Autor:
J Mullick, Phillip B. Hylemon, Z. R. Vlahcevic, Y P Rao, R. T. Stravitz, Darrell H. Mallonee, Narayan G. Avadhani
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 70:1-14
In vitro and in vivo studies have shown that the sterol 27-hydroxylase (CYP27) gene is transcriptionally repressed by hydrophobic bile acids. The molecular mechanism(s) of repression of CYP27 by bile acids is unknown. To identify the bile acid respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ebcd3150c01540ed8074b7678609bea
https://doi.org/10.1016/s0960-0760(99)00099-0
https://doi.org/10.1016/s0960-0760(99)00099-0
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 272:G1109-G1115
Toxic bile salts induce hepatocyte apoptosis, a model relevant to liver injury during cholestasis. However, the signaling mechanisms culminating in bile salt-induced apoptosis remain unclear. Because protein kinase C (PKC) is activated by bile salts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d413fd080bd569adc4c14b331bbdd885
https://doi.org/10.1152/ajpgi.1997.272.5.g1109
https://doi.org/10.1152/ajpgi.1997.272.5.g1109
Autor:
Douglas M. Heuman, C. D. Schteingart, H.-T. Ton-Nu, Phillip B. Hylemon, R. T. Stravitz, Lee R. Hagey, Z. R. Vlahcevic, A. F. Hofmann
Publikováno v:
Journal of Biological Chemistry. 268:13987-13993
The role of bile acids in the regulation of cholesterol 7 alpha-monooxygenase (EC 1.14.13.17) was characterized using primary cultures of rat hepatocytes supplemented with dexamethasone and thyroxine. Taurocholate and taurodeoxycholate (50 microM) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f993efd0d15878e910d834ee186895
https://doi.org/10.1016/s0021-9258(19)85199-2
https://doi.org/10.1016/s0021-9258(19)85199-2
Autor:
A, Sethi, R T, Stravitz
Publikováno v:
Alimentary pharmacologytherapeutics. 25(3)
Survival 10 years after orthotopic liver transplantation now approaches 65%. Consequently, community doctors must manage the metabolic and neoplastic complications of orthotopic liver transplantation in an ageing population.To review common sources o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a85b4c17e2b8d62c99aad1a52050ea4d
https://pubmed.ncbi.nlm.nih.gov/17217455
https://pubmed.ncbi.nlm.nih.gov/17217455
Autor:
R K, Sterling, J J, Salvatori, V A, Luketic, A J, Sanyal, A S, Fulcher, R T, Stravitz, M J, Contos, A S, Mills, M L, Shiffman
Publikováno v:
Alimentary pharmacologytherapeutics. 20(9)
Ursodeoxycholic acid has been ineffective in the treatment of primary sclerosing cholangitis. Because the pathogenesis of primary sclerosing cholangitis is related to immune destruction of bile duct epithelium, several immune suppressive agents have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e586c7b2b005a499f0f20d7e360c2183
https://pubmed.ncbi.nlm.nih.gov/15882250
https://pubmed.ncbi.nlm.nih.gov/15882250
Autor:
Y P, Rao, Z R, Vlahcevic, R T, Stravitz, D H, Mallonee, J, Mullick, N G, Avadhani, P B, Hylemon
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 70(1-3)
In vitro and in vivo studies have shown that the sterol 27-hydroxylase (CYP27) gene is transcriptionally repressed by hydrophobic bile acids. The molecular mechanism(s) of repression of CYP27 by bile acids is unknown. To identify the bile acid respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4de256292cc84d42cb2845b9f2448d33
https://pubmed.ncbi.nlm.nih.gov/10528998
https://pubmed.ncbi.nlm.nih.gov/10528998