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pro vyhledávání: '"R T, Premont"'
Autor:
R T, Premont, N, Vitale
Publikováno v:
Methods in enzymology. 329
Publikováno v:
The Journal of biological chemistry. 275(29)
We recently characterized a novel protein, GIT1, that interacts with G protein-coupled receptor kinases and possesses ADP-ribosylation factor (ARF) GTPase-activating protein activity. A second ubiquitously expressed member of the GIT protein family,
Publikováno v:
The Journal of biological chemistry. 274(41)
G protein-coupled receptor kinases (GRKs) desensitize G protein-coupled receptors by phosphorylating activated receptors. The six known GRKs have been classified into three subfamilies based on sequence and functional similarities. Examination of the
Publikováno v:
The Journal of biological chemistry. 274(16)
Previous studies have demonstrated that beta-arrestin1 serves to target G protein-coupled receptors for internalization via clathrin-coated pits and that its endocytic function is regulated by dephosphorylation at the plasma membrane. Using the yeast
Autor:
L, Ménard, S S, Ferguson, L S, Barak, L, Bertrand, R T, Premont, A M, Colapietro, R J, Lefkowitz, M G, Caron
Publikováno v:
Biochemistry. 35(13)
We recently reported that a beta2-adrenergic receptor (beta2AR) mutant, Y326A, defective in its ability to sequester in response to agonist stimulation was a poor substrate for G protein-coupled receptor kinase (GRK)-mediated phosphorylation; however
Publikováno v:
The Journal of biological chemistry. 270(25)
Upon illumination, rhodopsin kinase (RK) phosphorylates the visual pigment rhodopsin, which is thought to partially terminate the biochemical events that follow photon absorption. RK enzymology was explored by mutagenesis of the residues Ser488, Thr4
Publikováno v:
The Journal of biological chemistry. 269(45)
GRK6, a 66-kDa serine/threonine protein kinase, is a recently identified member of the G protein-coupled receptor kinase (GRK) family. GRKs are involved in the phosphorylation of seven-transmembrane receptors, a process mediating desensitization of s
Publikováno v:
The Journal of biological chemistry. 269(9)
A novel member of the family of G protein-coupled receptor kinases (GRKs), named GRK5, has been cloned from bovine taste epithelium. The cDNA sequence predicts a 590-amino acid protein with high overall similarity to rhodopsin kinase. GRK5 mRNA is fo
Autor:
R T, Premont
Publikováno v:
Methods in enzymology. 238
Publikováno v:
Methods in enzymology. 238