Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R T, Bartus"'
Autor:
R T, Bartus
Publikováno v:
Current opinion in drug discoverydevelopment. 2(2)
The blood-brain barrier (BBB) serves as an exquisitely controlled, functional gate to the central nervous system (CNS). It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6b09c97b1ed4e492a318677eb3e3864
https://pubmed.ncbi.nlm.nih.gov/19649942
https://pubmed.ncbi.nlm.nih.gov/19649942
Publikováno v:
Neuro-oncology. 1(4)
Accumulating evidence suggests that dexamethasone might decrease permeability of the blood-brain tumor barrier, further limiting the delivery of agents into brain tumors. The bradykinin B2 receptor agonist, Cereport (RMP-7), selectively increases per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cde7943eeb90d2e3d8295ab44ec9564e
https://pubmed.ncbi.nlm.nih.gov/11550318
https://pubmed.ncbi.nlm.nih.gov/11550318
Autor:
D F, Emerich, P, Snodgrass, R L, Dean, D, Lafreniere, M, Agostino, T, Wiens, H, Xiong, B, Hasler, J, Marsh, M, Pink, B S, Kim, R T, Bartus
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(2)
Delivery of chemotherapeutic agents to solid peripheral tumors is compromised because the impaired microvasculature within and surrounding tumors limits diffusion and convection of agents from the vasculature to the tumor. Using a variety of rat tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01b370340b37c337da312c53cb72d1c7
https://pubmed.ncbi.nlm.nih.gov/11160651
https://pubmed.ncbi.nlm.nih.gov/11160651
Autor:
D F, Emerich, R L, Dean, P, Snodgrass, D, Lafreniere, M, Agostino, T, Wiens, H, Xiong, B, Hasler, J, Marsh, M, Pink, B S, Kim, B, Perdomo, R T, Bartus
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(2)
Intravenous infusions of the bradykinin agonist Cereport (labradimil, formerly RMP-7) enhance delivery of concomitantly administered hydrophilic chemotherapeutic agents to solid tumors. The enhanced delivery produces greater in vivo efficacy of chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84174aefb1cb3273d76ea63fa8afdfca
https://pubmed.ncbi.nlm.nih.gov/11160652
https://pubmed.ncbi.nlm.nih.gov/11160652
Publikováno v:
Pharmaceutical research. 17(10)
The following experiments determined whether intravenous infusions of Cereport enhance delivery of chemotherapeutics and prolong survival in rats with metastatic tumors in the brain.Autoradiography and scintillation were used to examine uptake of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88cdc14e137d26cb1b0150e4d4770c80
https://pubmed.ncbi.nlm.nih.gov/11145226
https://pubmed.ncbi.nlm.nih.gov/11145226
Publikováno v:
The Journal of comparative neurology. 427(1)
Bradykinin has long been known to exist in the central nervous system and has been hypothesized to mediate specific functions. Despite an increasing understanding of the functions of bradykinin, little is known about the cell types expressing the bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef9725e4b42908d723329032ec695c5e
https://pubmed.ncbi.nlm.nih.gov/11042588
https://pubmed.ncbi.nlm.nih.gov/11042588
Autor:
D F, Emerich, S R, Winn, P, Snodgrass, D, LaFreniere, M, Agostino, T, Wiens, H, Xiong, R T, Bartus
Publikováno v:
Pharmaceutical research. 17(7)
Delivery of chemotherapeutics using implantable, biodegradable polymers provides a potentially powerful method of treating brain tumors. The present studies examined the ability of injectable microspheres, formulated to release carboplatin or BCNU fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8e54e2e9cfafa4973efa6844e21e5bf
https://pubmed.ncbi.nlm.nih.gov/10990194
https://pubmed.ncbi.nlm.nih.gov/10990194
Autor:
D F, Emerich, S R, Winn, Y, Hu, J, Marsh, P, Snodgrass, D, LaFreniere, T, Wiens, B P, Hasler, R T, Bartus
Publikováno v:
Pharmaceutical research. 17(7)
Implantation of biodegradable polymers provides a powerful method to deliver high, sustained concentrations of chemotherapeutics to brain tumors. The present studies examined the ability of injectable polymeric microspheres, formulated to release car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::737e6b34313cd34a8df482aa982755f0
https://pubmed.ncbi.nlm.nih.gov/10990193
https://pubmed.ncbi.nlm.nih.gov/10990193
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(3)
Several experiments studied the effects of i.v. infusions of the bradykinin agonist, Cereport (RMP-7), on permeability of the blood-brain tumor barrier in rat gliomas. First, the ability of Cereport to increase uptake of two poorly blood-brain barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9a8d023398c8b4b5099363278acd54b
https://pubmed.ncbi.nlm.nih.gov/10869391
https://pubmed.ncbi.nlm.nih.gov/10869391
Publikováno v:
Alcoholism, clinical and experimental research. 23(11)
This study was planned to determine the feasibility of using a slow release naloxone preparation to treat alcoholism, because compliance with medication is a significant problem in alcoholics.Experiments were performed in alcohol-preferring P rats ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f197f3a4e9a0422d29bd2a27e6d1276
https://pubmed.ncbi.nlm.nih.gov/10591592
https://pubmed.ncbi.nlm.nih.gov/10591592