Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells.

Autor: Kim MS; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Kim H; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lee G; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2024 Aug; Vol. 13 (21), pp. e2303041. Date of Electronic Publication: 2024 Feb 11.

Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy

Autor: D F, Emerich, P, Snodgrass, R L, Dean, D, Lafreniere, M, Agostino, T, Wiens, H, Xiong, B, Hasler, J, Marsh, M, Pink, B S, Kim, R T, Bartus

Publikováno v: The Journal of pharmacology and experimental therapeutics. 296(2)

Delivery of chemotherapeutic agents to solid peripheral tumors is compromised because the impaired microvasculature within and surrounding tumors limits diffusion and convection of agents from the vasculature to the tumor. Using a variety of rat tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01b370340b37c337da312c53cb72d1c7
https://pubmed.ncbi.nlm.nih.gov/11160651

Intravenous cereport (RMP-7) enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tumors in the brain

Autor: D F, Emerich, R L, Dean, J, Marsh, M, Pink, D, Lafreniere, P, Snodgrass, R T, Bartus

Publikováno v: Pharmaceutical research. 17(10)

The following experiments determined whether intravenous infusions of Cereport enhance delivery of chemotherapeutics and prolong survival in rats with metastatic tumors in the brain.Autoradiography and scintillation were used to examine uptake of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88cdc14e137d26cb1b0150e4d4770c80
https://pubmed.ncbi.nlm.nih.gov/11145226

Injectable chemotherapeutic microspheres and glioma II: enhanced survival following implantation into deep inoperable tumors

Autor: D F, Emerich, S R, Winn, P, Snodgrass, D, LaFreniere, M, Agostino, T, Wiens, H, Xiong, R T, Bartus

Publikováno v: Pharmaceutical research. 17(7)

Delivery of chemotherapeutics using implantable, biodegradable polymers provides a potentially powerful method of treating brain tumors. The present studies examined the ability of injectable microspheres, formulated to release carboplatin or BCNU fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8e54e2e9cfafa4973efa6844e21e5bf
https://pubmed.ncbi.nlm.nih.gov/10990194

Intravenous cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival

Autor: R T, Bartus, P, Snodgrass, J, Marsh, M, Agostino, A, Perkins, D F, Emerich

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(3)

Several experiments studied the effects of i.v. infusions of the bradykinin agonist, Cereport (RMP-7), on permeability of the blood-brain tumor barrier in rat gliomas. First, the ability of Cereport to increase uptake of two poorly blood-brain barrie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9a8d023398c8b4b5099363278acd54b
https://pubmed.ncbi.nlm.nih.gov/10869391