Zobrazeno 1 - 10
of 477
pro vyhledávání: '"R Steinert"'
Autor:
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β sup
Externí odkaz:
https://doaj.org/article/52604fc9b84246b693fbae8899b28894
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011309 (2023)
Prion diseases, also known as transmissible spongiform encephalopathies, are rare, progressive, and fatal neurodegenerative disorders, which are caused by the accumulation of the misfolded cellular prion protein (PrPC). The resulting cytotoxic prion
Externí odkaz:
https://doaj.org/article/82443dbd323f4996be39df97ac4f9fd3
Autor:
Aelfwin Stone, Oliver Cujic, Angel Rowlett, Sophia Aderhold, Emma Savage, Bruce Graham, Joern R. Steinert
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 15 (2023)
IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals. One such prote
Externí odkaz:
https://doaj.org/article/51c005a7a45d43ba8aadd3eb06271b38
Autor:
Ella Dunn, Joern R. Steinert, Aelfwin Stone, Virender Sahota, Robin S. B. Williams, Stuart Snowden, Hrvoje Augustin
Publikováno v:
Cells, Vol 12, Iss 17, p 2163 (2023)
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterised by progressive degeneration of the motor neurones. An expanded GGGGCC (G4C2) hexanucleotide repeat in C9orf72 is the most common genetic cause of ALS and fr
Externí odkaz:
https://doaj.org/article/e183861f2de04cafaf6c2fb2b7866f6d
Autor:
Amy Richardson, Victoria Ciampani, Mihai Stancu, Kseniia Bondarenko, Sherylanne Newton, Joern R Steinert, Nadia Pilati, Bruce P Graham, Conny Kopp-Scheinpflug, Ian D Forsythe
Publikováno v:
eLife, Vol 11 (2022)
Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited thi
Externí odkaz:
https://doaj.org/article/7a5ebf62e769488487d88c858f972480
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 3, Pp 387-390 (2019)
Neurodegenerative disorders are often associated with cellular dysfunction caused by underlying protein-misfolding signalling. Numerous neuropathologies are diagnosed at late stage symptomatic changes which occur in response to these molecular malfun
Externí odkaz:
https://doaj.org/article/022e6e05f49446d0828eab31f74f1b38
Autor:
Jereme G. Spiers, Hsiao-Jou Cortina Chen, Tiffany L. Barry, Julie-Myrtille Bourgognon, Joern R. Steinert
Publikováno v:
Free Radical Biology and Medicine. 192:182-190
Neurodegenerative diseases are associated with a multitude of dysfunctional cellular pathways. One major contributory factor is a redox stress challenge during the development of several protein misfolding conditions including Alzheimer's (AD), Parki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3131bdb77c09db66635076f476aa06ec
https://doi.org/10.1016/j.freeradbiomed.2022.09.025
https://doi.org/10.1016/j.freeradbiomed.2022.09.025
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Many neurodegenerative conditions and age-related neuropathologies are associated with increased levels of reactive oxygen species (ROS). The cap “n” collar (CncC) family of transcription factors is one of the major cellular system that fights ox
Externí odkaz:
https://doaj.org/article/c122bce7c06c4d45a5e0e67f4c057172
Autor:
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2003611 (2018)
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl
Externí odkaz:
https://doaj.org/article/9e9cf68bba724e81a075808600ab4057
Autor:
Joern R. Steinert, Haitham Amal
Publikováno v:
Free radical biologymedicine. 194
Nitric oxide and other redox active molecules such as oxygen free radicals provide essential signalling in diverse neuronal functions, but their excess production and insufficient scavenging induces cytotoxic redox stress which is associated with num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba65c6ab093bbbeb1204ebc10e09d32
https://pubmed.ncbi.nlm.nih.gov/36435368
https://pubmed.ncbi.nlm.nih.gov/36435368