Zobrazeno 1 - 10
of 484
pro vyhledávání: '"R Stanford"'
Publikováno v:
eLife, Vol 13 (2024)
The neural mechanisms that willfully direct attention to specific locations in space are closely related to those for generating targeting eye movements (saccades). However, the degree to which the voluntary deployment of attention to a location nece
Externí odkaz:
https://doaj.org/article/4e05784855a548a1893094eba0fa726d
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110488- (2024)
Summary: The ability to suppress inappropriate actions and respond rapidly to appropriate ones matures late in life, after puberty. We investigated the development of this capability in monkeys trained to look away from a lone, bright stimulus (antis
Externí odkaz:
https://doaj.org/article/539813d5763045d4b9bc47fe1bef7091
Autor:
Kyla B. Tooley, Ana J. Chucair-Elliott, Sarah R. Ocañas, Adeline H. Machalinski, Kevin D. Pham, Walker Hoolehan, Adam M. Kulpa, David R. Stanford, Willard M. Freeman
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-27 (2023)
Abstract Background Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific CNS cell types in hea
Externí odkaz:
https://doaj.org/article/773d1b37618b472fabb42ce59c6c91ce
Autor:
Emilio Salinas, Terrence R Stanford
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0297792 (2024)
Intuitively, combining multiple sources of evidence should lead to more accurate decisions than considering single sources of evidence individually. In practice, however, the proper computation may be difficult, or may require additional data that ar
Externí odkaz:
https://doaj.org/article/019c779b0ad14d3192d3dca04ea1fe29
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In primate area LIP, target selection and the accumulation of sensory evidence are considered a single process. Here, the authors use urgent choice tasks to show that spatial selection in LIP is distinct from, and may even conflict with, evidence acc
Externí odkaz:
https://doaj.org/article/ffbd428d5d7a4f11bb55b200e3a574ae
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106253- (2023)
Summary: Selecting where to look next depends on both the salience of objects and current goals (what we are looking for), but discerning their relative contributions over the time frame of typical visuomotor decisions (200–250 ms) has been difficu
Externí odkaz:
https://doaj.org/article/93b3cc780387419782497ad9402f790a
Publikováno v:
eLife, Vol 11 (2022)
To generate the next eye movement, oculomotor circuits take into consideration the physical salience of objects in view and current behavioral goals, exogenous and endogenous influences, respectively. However, the interactions between exogenous and e
Externí odkaz:
https://doaj.org/article/e9d37486ac034ed2bf6727e648f56434
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various C
Externí odkaz:
https://doaj.org/article/63e1a0afff5b4799ad0eb10f2eaeecc0
Autor:
Katherine R. Stanford, Joanne M. Ajmo, Parmvir K. Bahia, Stephen H. Hadley, Thomas E. Taylor-Clark
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Objective Redox-sensitive green fluorescent protein (roGFP) is a genetically-encoded redox-sensitive protein used to detect cellular oxidative stress associated with reactive oxygen species production. Here we replaced the cysteine at positi
Externí odkaz:
https://doaj.org/article/ec9720889dec49cfbe6dc9a46521b94d
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Saccades have been extensively used to report choices in perceptual decision making studies yet little is known about the influence of covert decision-related processes on saccade metrics. Here, the authors demonstrate that saccade kinematics is a re
Externí odkaz:
https://doaj.org/article/af94a07424a2420a985c0d2562d7adfb