Zobrazeno 1 - 10
of 237
pro vyhledávání: '"R Spengler"'
Autor:
Elif Karaaslan, Teresa E. Sorvillo, Florine E. M. Scholte, Troy Justin O’Neal, Stephen R. Welch, Katherine A. Davies, JoAnn D. Coleman-McCray, Jessica R. Harmon, Jana M. Ritter, Scott D. Pegan, Joel M. Montgomery, Jessica R. Spengler, Christina F. Spiropoulou, Éric Bergeron
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Immunizing mice with Crimean-Congo hemorrhagic fever virus (CCHFV) nucleoprotein (NP), glycoprotein precursor (GPC), or with the GP38 domain of GPC, can be protective when the proteins are delivered with viral vectors or as a DNA or RNA vacc
Externí odkaz:
https://doaj.org/article/c721bc91b40f410a9bf386bc947427cd
Autor:
Teresa E. Sorvillo, Jana M. Ritter, Stephen R. Welch, JoAnn D. Coleman-McCray, Katherine A. Davies, Heather M. Hayes, Scott D. Pegan, Joel M. Montgomery, Éric Bergeron, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Crimean-Congo haemorrhagic fever virus (CCHFV) causes human disease ranging from subclinical to a fatal haemorrhagic syndrome. Determinants of CCHF pathogenesis are largely unknown and animal models that recapitulate human disease are limited. A rece
Externí odkaz:
https://doaj.org/article/1c808a917ff543498e491dd36c1538ff
Autor:
Teresa E. Sorvillo, Elif Karaaslan, Florine E. M. Scholte, Stephen R. Welch, JoAnn D. Coleman-McCray, Sarah C. Genzer, Jana M. Ritter, Heather M. Hayes, Shilpi Jain, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lack of efficacious vaccines and antivirals. A CCHF virus replicon particle (VRP) has previously shown protecti
Externí odkaz:
https://doaj.org/article/b8ba679dc1ff413493a3bbf4a114e16c
Autor:
Florine E.M. Scholte, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Katherine A. Davies, Scott D. Pegan, Joel M. Montgomery, Christina F. Spiropoulou, Éric Bergeron
Publikováno v:
Virus Research, Vol 345, Iss , Pp 199398- (2024)
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus with a wide geographic spread that can cause severe and lethal disease. No specific medical countermeasures are approved to combat this illness. The CCHFV L protein contains an
Externí odkaz:
https://doaj.org/article/11d89857f10b4fc099fb394c35126e4e
Autor:
Jonathan C. Guito, Shannon G. M. Kirejczyk, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, James Graziano, Jessica R. Spengler, Jessica R. Harmon, David M. Wozniak, Joseph B. Prescott, Jonathan S. Towner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bats are increasingly recognized as reservoirs of emerging zoonotic pathogens. Egyptian rousette bats (ERBs) are the known reservoir of Marburg virus (MARV), a filovirus that causes deadly Marburg virus disease (MVD) in humans. However, ERBs
Externí odkaz:
https://doaj.org/article/681c496e7b3340dbb8f18289ffb53d6e
Autor:
Katherine A. Davies, Stephen R. Welch, Teresa E. Sorvillo, JoAnn D. Coleman-McCray, María Laura Martin, Julia M. Brignone, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Reverse-transcription quantitative polymerase chain reaction assays are frequently used to evaluate gene expression in animal model studies. Data analyses depend on normalization using a suitable reference gene (RG) to minimize effects of va
Externí odkaz:
https://doaj.org/article/a5d3c87bfb844e439ea727a71d54082b
Autor:
Jessica A. Belser, Troy J. Kieran, Zoë A. Mitchell, Xiangjie Sun, Kristin Mayfield, Terrence M. Tumpey, Jessica R. Spengler, Taronna R. Maines
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/73b082c9a78642089970fbfda09f67ef
Autor:
Jonathan C. Guito, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Jessica R. Harmon, Joann D. Coleman-McCray, Mariano Sanchez-Lockhart, Gustavo F. Palacios, Jonathan S. Towner, Joseph B. Prescott
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, Rousettus aegyptiacus), the only known MARV reservoir, shows no overt illness upon natural or e
Externí odkaz:
https://doaj.org/article/64f5d5cf07a84829b6bb43092a35316d
Autor:
Stephen R. Welch, Sarah C. Genzer, JoAnn D. Coleman-McCray, Jessica R. Harmon, Florine E.M. Scholte, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1390-1393 (2022)
Lassa fever (LF) is endemic to broad regions of West Africa. Infection with Lassa virus (LASV), the etiologic agent of LF, results in a spectrum of clinical signs in humans, including severe and lethal hemorrhagic disease. Person-to-person transmissi
Externí odkaz:
https://doaj.org/article/f6887cdc509741ae8a6c2d7048b6af7c
Autor:
Ian A. Durie, Zahra R. Tehrani, Elif Karaaslan, Teresa E. Sorvillo, Jack McGuire, Joseph W. Golden, Stephen R. Welch, Markus H. Kainulainen, Jessica R. Harmon, Jarrod J. Mousa, David Gonzalez, Suzanne Enos, Iftihar Koksal, Gurdal Yilmaz, Hanife Nur Karakoc, Sanaz Hamidi, Cansu Albay, Jessica R. Spengler, Christina F. Spiropoulou, Aura R. Garrison, Mohammad M. Sajadi, Éric Bergeron, Scott D. Pegan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide in
Externí odkaz:
https://doaj.org/article/ab186bd397154dcabe6fc31995264ac7