Zobrazeno 1 - 10
of 676
pro vyhledávání: '"R Sparrow"'
Autor:
J Peyton, M Hadjistylli, I Tziortzis, E Erotokritou, M Demetriou, Y Samuel, V Anastasi, G Fyttis, L Hadjioannou, C Ieronymidou, N Kassinis, P Kleitou, D Kletou, A Mandoulaki, N Michailidis, A Papatheodoulou, G Payiattas, D Sparrow, R Sparrow, K Turvey, E Tzirkalli, A I Varnava, O L Pescott
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0256777 (2022)
Biodiversity monitoring plays an essential role in tracking changes in ecosystems, species distributions and abundances across the globe. Data collected through both structured and unstructured biodiversity recording can inform conservation measures
Externí odkaz:
https://doaj.org/article/d8b0c52287fa47e9aabfd51e1d875233
Autor:
Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A. Jenny, Nicholas D. Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang, Janet R. Sparrow, Chyuan-Sheng Lin, Stephen H. Tsang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing therapies for retinal di
Externí odkaz:
https://doaj.org/article/f06c541ff511434ab196ba88974fd001
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
AimIron dysregulation in conjunction with other disease processes may exacerbate retinal degeneration. We employed models of iron overload and iron chelation to explore the interactions between iron-catalyzed oxidation and photoreactive bisretinoid l
Externí odkaz:
https://doaj.org/article/a7610c600fc24bcd8b4c8261a335b3c0
Autor:
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-20 (2023)
Abstract Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to syste
Externí odkaz:
https://doaj.org/article/dad16b5228fa4f2aae01a11f4bb1e21e
Autor:
Jin Kyun Oh, José G. Vargas Del Valle, Jose Ronaldo Lima de Carvalho, Young Joo Sun, Sarah R. Levi, Joseph Ryu, Jing Yang, Takayuki Nagasaki, Andres Emanuelli, Nailyn Rasool, Rando Allikmets, Janet R. Sparrow, Natalio J. Izquierdo, Jacque L. Duncan, Vinit B. Mahajan, Stephen H. Tsang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract Background Inherited retinal dystrophies describe a heterogeneous group of retinal diseases that lead to the irreversible degeneration of rod and cone photoreceptors and eventual blindness. Recessive loss-of-function mutations in Tubulin Tyr
Externí odkaz:
https://doaj.org/article/1e65e94f0222440682536d647ca33028
Autor:
Masha Kolesnikova, Jose Ronaldo Lima de Carvalho Jr., Rait Parmann, Angela H. Kim, Vinit B. Mahajan, Stephen H. Tsang, Janet R. Sparrow
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Introduction Leber congenital amaurosis (LCA) type 2, due to disease‐causing variants in RPE65, is characterized by severe visual loss in early infancy. Current treatments include voretigene neparvovec‐rzyl (VN) for RPE65‐associated LC
Externí odkaz:
https://doaj.org/article/01889da9e93d413c8c49643b3efd6c2b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12327 (2023)
The method of quantitative fundus autofluorescence (qAF) can be used to assess the levels of bisretinoids in retinal pigment epithelium (RPE) cells so as to aid the interpretation and management of a variety of retinal conditions. In this review, we
Externí odkaz:
https://doaj.org/article/ea647f276b8e44c5b6fecc753ac364ea
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Characterization of vascular impairment in Best vitelliform macular dystrophy (BVMD) is essential for the development of treatment modalities and therapy trials. As such, we seek to characterize the choriocapillaris (CC) at each stage of the
Externí odkaz:
https://doaj.org/article/9f88910d479745578728bcfac9cc86fe
Autor:
AtLee T. D. Watson, Victor J. Johnson, Michael I. Luster, Gary R. Burleson, Dawn M. Fallacara, Barney R. Sparrow, Mark F. Cesta, Michelle C. Cora, Keith R. Shockley, Matt D. Stout, Chad R. Blystone, Dori R. Germolec
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 1-12 (2021)
Sulfolane is a solvent used in the petrochemical industry and a groundwater contaminant in areas near refineries. The current studies were conducted to assess the impact of oral exposure to sulfolane on the immune system using two models: (1) a perin
Externí odkaz:
https://doaj.org/article/dedc6a16c38a4f61826536e8e9921adf
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Fundus autofluorescence is a valuable imaging tool in the diagnosis of inherited retinal dystrophies. With the advent of gene therapy and the numerous ongoing clinical trials for inherited retinal degenerations, quantifiable and reliable out
Externí odkaz:
https://doaj.org/article/636c6ae62e4144d8be8ee7b4ab5a007a