Zobrazeno 1 - 10
of 31
pro vyhledávání: '"R Scott Dunn"'
Autor:
Yu-Yo Sun, Yury M Morozov, Dianer Yang, Yikun Li, R Scott Dunn, Pasko Rakic, Pak H Chan, Koji Abe, Diana M Lindquist, Chia-Yi Kuan
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98807 (2014)
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-eda
Externí odkaz:
https://doaj.org/article/46b6060a8b7243149c112cf5d943802f
Autor:
Istvan Pirko, Yi Chen, Anne K Lohrey, Jeremiah McDole, Jeffrey D Gamez, Kathleen S Allen, Kevin D Pavelko, Diana M Lindquist, R Scott Dunn, Slobodan I Macura, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31459 (2012)
MRI is sensitive to tissue pathology in multiple sclerosis (MS); however, most lesional MRI findings have limited correlation with disability. Chronic T1 hypointense lesions or "T1 black holes" (T1BH), observed in a subset of MS patients and thought
Externí odkaz:
https://doaj.org/article/62624d18afa148c58f91e3203c4c2c51
Autor:
Istvan Pirko, Rhonda Cardin, Yi Chen, Anne K Lohrey, Diana M Lindquist, R Scott Dunn, Robert Zivadinov, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32767 (2012)
Recent evidence in multiple sclerosis (MS) suggests that active CMV infection may result in more benign clinical disease. The goal of this pilot study was to determine whether underlying murine CMV (MCMV) infection affects the course of the Theiler's
Externí odkaz:
https://doaj.org/article/14c633209a9746139b2e53de79829582
Autor:
June Goto, Diana M. Lindquist, R. Scott Dunn, A. Scott Emmert, Preston A. Schultz, Francesco T. Mangano, Crystal Shula, Eri Iwasawa, Yueh-Chiang Hu, Elizabeth M. Fugate
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
Neonatal hydrocephalus affects about one child per 1000 births and is a major congenital brain abnormality. We previously discovered a gene mutation within the coiled-coil domain-containing 39 (Ccdc39) gene, which causes the progressive hydrocephalus
Autor:
Yu Michael Zhou, Jinbang Guo, Cynthia Davidson, Zackary I. Cleveland, William D. Hardie, Teckla G. Akinyi, R. Scott Dunn, Jason C. Woods
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L488-L499
Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To understand the mechanisms underlying pulmonary fibrosis and assess potential therapies, mouse mode
Autor:
Edwin Jousma, Mi-Ok Kim, AeRang Kim, Nancy Ratner, Timothy P. Cripe, Jianqiang Wu, Brigitte C. Widemann, Eva Dombi, Beverly Schnell, R. Scott Dunn, Diana M. Lindquist
Publikováno v:
Pediatric Blood & Cancer. 58:173-180
Background Neurofibromatosis type 1 (NF1) is an inherited disease predisposing affected patients to variable numbers of benign neurofibromas. To date there are no effective chemotherapeutic drugs available for this slow growing tumor. Molecularly tar
Publikováno v:
Neuromuscular Disorders. 21:68-73
Delta-sarcoglycan (δ-sarcoglycan) null, Scgd(-/-), mice develop cardiac and skeletal muscle histopathological alterations similar to those in humans with limb-girdle muscular dystrophy. The objective of this study was to assess the feasibility of us
Autor:
Yury M. Morozov, Marsha Wills-Karp, Noboru Mizushima, Scott K. Holland, Pasko Rakic, Roger J. Davis, Faisal Adhami, Jay L. Degen, Chia-Yi Kuan, Bernard J. Dardzinski, John N. Lorenz, Charles V. Vorhees, Aryn Schloemer, Guanghong Liao, Vincent J. Schmithorst, R. Scott Dunn, Frank R. Sharp
Publikováno v:
The American Journal of Pathology. 169:566-583
Hypoxia is a critical factor for cell death or survival in ischemic stroke, but the pathological consequences of combined ischemia-hypoxia are not fully understood. Here we examine this issue using a modified Levine/Vannucci procedure in adult mice t
Autor:
Feng Shiun Shie, Claire A. Chougnet, Ian P. Lewkowich, Yi Hsuan Lee, Jessica M. Baumann, Diana M. Lindquist, Chia-Yi Kuan, Siddhartha Kumar Bhaumik, Shang Hsuan Lin, Chia-Yang Liu, Dianer Yang, Yu-Yo Sun, Yikun Li, Suhas G. Kallapur, R. Scott Dunn, Kaja Murali-Krishna, Marsha Wills-Karp, Yujin Zhang, Xiaoyi Lin
Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic–ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to the CNS damage remain uncertain. Here we report evidence for brain influx of T-helper 17 (TH17)-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d2822ce6f8285d89a3a9f6461855bb
https://europepmc.org/articles/PMC4252554/
https://europepmc.org/articles/PMC4252554/
Autor:
Vincent J. Schmithorst, Scott K. Holland, Jerzy P. Szaflarski, Michael Privitera, R. Scott Dunn
Publikováno v:
Epilepsy & Behavior. 5:244-252
Functional MRI (fMRI) studies of memory with coarse resolution of 4 x 4 x 5 mm often fail to demonstrate blood oxygenation level-dependent (BOLD) activation in the hippocampal formation. This failure occurs when nonactivating white matter is averaged