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Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 28:232-238
Autor:
Steinn Jonsson, Ingileif Jonsdottir, R. Schneerson, G. Schiffman, G. Vidarsson, H. Valdimarsson
Publikováno v:
European respiratory journal, 20(4), 813-818. European Respiratory Society
This paper examines how pneumococcal type 6B polysaccharide conjugated to tetanus toxoid (Pn6B-TT) compares to a 23 valent pneumococcal vaccine (pneumococcal polysaccharide (PPS)-23) with respect to immunogenicity and serum opsonic activity in patien
Autor:
K M Edwards, B D Baxter, J I Ward, Dace V. Madore, G R Siber, D C Phipps, Porter W. Anderson, H Käyhty, Holder P, C E Frasch, G M Carlone, R G Hamilton, C C Peeters, R Schneerson
Publikováno v:
Clinical Diagnostic Laboratory Immunology. 3:84-88
An interlaboratory study was conducted to determine whether an enzyme-linked immunosorbent assay (ELISA) with an antigen preparation composed of various-sized fragments of Haemophilus influenzae type b polysaccharide conjugated to human serum albumin
Publikováno v:
Infection and Immunity. 63:4429-4432
A search for human monoclonal antibodies to protective antigens of bacteria revealed an immunoglobulin M lambda chain [IgM(lambda); designated IgMBEN] reactive with the Vi capsular polysaccharide of Salmonella typhi. Vi, a linear homopolymer of alpha
Autor:
Ira Pastan, Dolores A. Bryla, R Schneerson, David J. FitzGerald, W W Karakawa, JohnB Robbins, A. Fattom, Douglas Watson, Xiuru Li, Joseph Shiloach
Publikováno v:
Infection and Immunity. 61:1023-1032
The synthesis, standardization, and immunogenicity in young outbred mice and clinical evaluation in adult volunteers of investigational vaccines designed to induce serum antibodies to the type 5 and type 8 capsular polysaccharides (CPs) of Staphyloco
Autor:
David J. FitzGerald, Joseph Shiloach, R Schneerson, A. Fattom, Ira Pastan, Dolores A. Bryla, W W Karakawa, JohnB Robbins
Publikováno v:
Infection and Immunity. 60:584-589
Staphylococcus aureus type 8 capsular polysaccharide (CP) was conjugated either to diphtheria toxoid or to Pseudomonas aeruginosa recombinant exoprotein A by using adipic acid dihydrazide (ADH) or N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) a
Publikováno v:
The Journal of Immunology. 147:2136-2140
Concurrent injection of monophosphoryl lipid A (MPL) in saline or as an oil-in-water emulsion enhanced both the primary and secondary serum antibody responses to the capsular polysaccharide (CP) components of seven conjugates: the enhanced responses
Publikováno v:
Infection and Immunity. 58:2547-2554
Healthy adult volunteers were injected either with one of two conjugates composed of Streptococcus pneumoniae type 12F polysaccharide (Pn12F) covalently coupled to diphtheria toxoid or with Pn12F alone (as a component of Pnu-Imune, a 23-valent pneumo