Zobrazeno 1 - 10
of 116
pro vyhledávání: '"R Schlimgen"'
Autor:
Roman R. Schlimgen, Francis C. Peterson, Raimond Heukers, Martine J. Smit, John D. McCorvy, Brian F. Volkman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target
Externí odkaz:
https://doaj.org/article/52636f4e898c4c9caf197813d718a9df
Autor:
Angela L. Zhou, Davin R. Jensen, Francis C. Peterson, Monica A. Thomas, Roman R. Schlimgen, Michael B. Dwinell, Brian C. Smith, Brian F. Volkman
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 163-169 (2023)
The mucosal chemokine CCL28 is a promising target for immunotherapy drug development due to its elevated expression level in epithelial cells and critical role in creating and maintaining an immunosuppressive tumor microenvironment. Using sulfotyrosi
Externí odkaz:
https://doaj.org/article/cda8960ad51a44dcad7771ca3279a769
Autor:
Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010355 (2022)
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1GT1) is a known agonist for CXCR1 and
Externí odkaz:
https://doaj.org/article/b58f3e9f294b4bb682ffd33432ab9a5c
Autor:
R P Taylor, E N Martin, M L Reinagel, A Nardin, M Craig, Q Choice, R Schlimgen, S Greenbaum, N L Incardona, H D Ochs
Publikováno v:
The Journal of Immunology. 159:4035-4044
We used Anger camera imaging in a monkey model to investigate the organ localization of a prototype particulate pathogen, 131I-labeled bacteriophage phi X174, after it was bound to the primate erythrocyte complement receptor and then cleared from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b2914b37a2c8f188d901f09516c847
https://doi.org/10.4049/jimmunol.159.8.4035
https://doi.org/10.4049/jimmunol.159.8.4035
Publikováno v:
European journal of immunology. 29(5)
Immune complexes (IC) bound to the primate erythrocyte (E) complement receptor (CR1) are cleared from the circulation of primates and localized to the liver. IC can be bound to E CR1 either via C3b opsonization or with cross-linked mAb complexes (het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28419f4e8532406a8f370f91f96b0e3f
https://pubmed.ncbi.nlm.nih.gov/10359112
https://pubmed.ncbi.nlm.nih.gov/10359112
Autor:
M. Kraus, R. Schlimgen
Publikováno v:
Antithrombin — Diagnostik und Therapie ISBN: 9783540636359
Die Verbrauchskoagulopathie (disseminierte intravasale Gerinnung, DIC) wird definiert als eine durch unterschiedliche Ursachen hervorgerufene, pathologische Aktivierung des Gerinnungssystems, die zum Verbrauch von Gerinnungsfaktoren und zur Bildung v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a61d98822450cdd0f3197a89ccc652c5
https://doi.org/10.1007/978-3-642-60305-1_7
https://doi.org/10.1007/978-3-642-60305-1_7
Publikováno v:
Kinderanästhesie ISBN: 9783540538486
Es sollte die Auswirkung der Intubation auf die mechanischen Eigenschaften der Lunge von Sauglingen und Kleinkindern wahrend der Exspiration untersucht werden.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde0132fb666561c7b97b6dfe3043f91
https://doi.org/10.1007/978-3-642-76519-3_44
https://doi.org/10.1007/978-3-642-76519-3_44
Autor:
McGuire, Tara K.1,2 (AUTHOR), Stasiewicz, Martyna1,2 (AUTHOR), Woods, Ian1,2 (AUTHOR), Dervan, Adrian G.1,2 (AUTHOR), O'Brien, Fergal J.1,2,3 (AUTHOR) fjobrien@rcsi.ie
Publikováno v:
Advanced Nanobiomed Research. Nov2023, Vol. 3 Issue 11, p1-26. 26p.
Publikováno v:
IFAC Proceedings Volumes. 15:205-211
Design and evaluation of a medical information system for the anaesthesiologist is the research application for which a two-operator design simulation configuration has been set up. A cognitive model is described to derive information structures and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96284f7963485edc7afcef0391bfd057
https://doi.org/10.1016/s1474-6670(17)62907-0
https://doi.org/10.1016/s1474-6670(17)62907-0