Zobrazeno 1 - 10
of 1 209
pro vyhledávání: '"R Sampson"'
Autor:
Adam M. Hamilton, Lisa Blackmer-Raynolds, Yaqing Li, Sean D. Kelly, Nardos Kebede, Anna E. Williams, Jianjun Chang, Sandra M. Garraway, Shanthi Srinivasan, Timothy R. Sampson
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Spinal cord injury (SCI) results in numerous systemic dysfunctions, including intestinal dysmotility and enteric nervous system (ENS) atrophy. The ENS has capacity to recover following perturbation, yet intestinal pathologies persist. With e
Externí odkaz:
https://doaj.org/article/15c1690b33ae465794ceaf50c419c3b4
Autor:
Pål Møller, Saskia Haupt, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Lone Sunde, Toni Seppälä, John Burn, Inge Bernstein, Gabriel Capella, D. Gareth Evans, Annika Lindblom, Ingrid Winship, Finlay Macrae, Lior Katz, Ido Laish, Elez Vainer, Kevin Monahan, Elizabeth Half, Karoline Horisberger, Leandro Apolinário da Silva, Vincent Heuveline, Christina Therkildsen, Charlotte Lautrup, Louise L Klarskov, Giulia Martina Cavestro, Gabriela Möslein, Eivind Hovig, Mev Dominguez-Valentin
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Colorectal cancers (CRCs) in the Lynch syndromes have been assumed to emerge through an accelerated adenoma-carcinoma pathway. In this model adenomas with deficient mismatch repair have an increased probability of acquiring additi
Externí odkaz:
https://doaj.org/article/b927da2164d549d2a1b8caf236ddd5ed
Autor:
Frederik C. Rust, Leslie R. Sampson, Adriana A. Cachia, Benoit M.J.A. Verhaeghe, Helena S. Fourie, Michelle A. Smit, Alwyn Hoffman, Wynand J.v.d.M. Steyn, Karien Venter, Samuel Lefophane
Publikováno v:
Journal of Transport and Supply Chain Management, Vol 18, Iss 0, Pp e1-e16 (2024)
Background: Foresight can be used to define futuristic orientated research and development (RD) that is required to position the road transport sector for a challenging future. Objectives: To develop a set of futuristic RD projects that could be add
Externí odkaz:
https://doaj.org/article/18e97282f5b64b5f955f328d32ada043
Autor:
Marianne J. Mullane, Hannah M. Thomas, Jonathan R. Carapetis, Catalina Lizama, Wesley Billingham, Matthew N. Cooper, Christine Everest, Claudia R. Sampson, Nelly Newall, Sarah Pearce, Francis Lannigan, Eamonn McNulty, Rebecca Cresp, Ariel O. Mace, Tina Barrow, Asha C. Bowen
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionGroup A streptococcus (GAS) infections, such as pharyngitis and impetigo, can lead to rheumatic fever and rheumatic heart disease (RHD). Australian Aboriginal and Torres Strait Islander populations experience high rates of RHD and GAS ski
Externí odkaz:
https://doaj.org/article/d444611d896b4eec82e109fd69401b0a
Autor:
Haydeh Payami, Gwendolyn Cohen, Charles F. Murchison, Timothy R. Sampson, David G. Standaert, Zachary D. Wallen
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-5 (2023)
Abstract Parkinson’s disease is the fastest-growing neurologic disease with seemingly no means of prevention. Intrinsic risk factors (age, sex, and genetics) are inescapable, but environmental factors are not. We identified repeated blows to the he
Externí odkaz:
https://doaj.org/article/9c8d1762417746bdbf7d1ad5f08d965c
Autor:
Pal Møller, Toni T. Seppälä, Aysel Ahadova, Emma J. Crosbie, Elke Holinski-Feder, Rodney Scott, Saskia Haupt, Gabriela Möslein, Ingrid Winship, Sanne W. Bajwa-ten Broeke, Kelly E. Kohut, Neil Ryan, Peter Bauerfeind, Laura E. Thomas, D. Gareth Evans, Stefan Aretz, Rolf H. Sijmons, Elizabeth Half, Karl Heinimann, Karoline Horisberger, Kevin Monahan, Christoph Engel, Giulia Martina Cavestro, Robert Fruscio, Naim Abu-Freha, Levi Zohar, Luigi Laghi, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Carlos Vaccaro, Adriana Della Valle, Benedito Mauro Rossi, Leandro Apolinário da Silva, Ivana Lucia de Oliveira Nascimento, Norma Teresa Rossi, Tadeusz Dębniak, Jukka-Pekka Mecklin, Inge Bernstein, Annika Lindblom, Lone Sunde, Sigve Nakken, Vincent Heuveline, John Burn, Eivind Hovig, Matthias Kloor, Julian R. Sampson, Mev Dominguez-Valentin, On behalf of the Prospective Lynch Syndrome Database (www.plsd.eu) and The European Hereditary Tumour Group (www.ehtg.org)
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract The recognition of dominantly inherited micro-satellite instable (MSI) cancers caused by pathogenic variants in one of the four mismatch repair (MMR) genes MSH2, MLH1, MSH6 and PMS2 has modified our understanding of carcinogenesis. Inherited
Externí odkaz:
https://doaj.org/article/952d37829e8040c192582717c1ee47f5
Autor:
Kitty Sherwood, Joseph C. Ward, Ignacio Soriano, Lynn Martin, Archie Campbell, Raheleh Rahbari, Ioannis Kafetzopoulos, Duncan Sproul, Andrew Green, Julian R. Sampson, Alan Donaldson, Kai-Ren Ong, Karl Heinimann, Maartje Nielsen, Huw Thomas, Andrew Latchford, Claire Palles, Ian Tomlinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract DNA repair defects underlie many cancer syndromes. We tested whether de novo germline mutations (DNMs) are increased in families with germline defects in polymerase proofreading or base excision repair. A parent with a single germline POLE o
Externí odkaz:
https://doaj.org/article/68fc09053a5a40998172c3984f36be2c
Autor:
Frederik C. Rust, Leslie R. Sampson, Adriana A. Cachia, Benoit M. Verhaeghe, Helena S. Fourie, Michelle A. Smit
Publikováno v:
Journal of Transport and Supply Chain Management, Vol 17, Iss 0, Pp e1-e13 (2023)
Background: In view of limited funding, research and development (RD) investment needs to be optimised for future impact. Road transport RD is complex and vary from road materials, design and traffic control to safety. Objectives: Future drivers, tr
Externí odkaz:
https://doaj.org/article/3531c6b2b6c54062a384d08fb5408cd7
Autor:
Jennifer L. Ridgeway, Erin O. Wissler Gerdes, Andrew Dodge, Chad P. Liedl, Michael B. Juntunen, Wendy J. S. Sundt, Amy Glasgow, Michelle A. Lampman, Angela L. Fink, Sara B. Severson, Grace Lin, Richard R. Sampson, Robert P. Peterson, Brian M. Murley, Aaron B. Klassen, Anuradha Luke, Paul A. Friedman, Tamara E. Buechler, James S. Newman, Rozalina G. McCoy
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background New patient-centered models of care are needed to individualize care and reduce high-cost care, including emergency department (ED) visits and hospitalizations for low- and intermediate-acuity conditions that could be managed outs
Externí odkaz:
https://doaj.org/article/a7774334900f48fb959a554859946023
Autor:
Zachary D. Wallen, Ayse Demirkan, Guy Twa, Gwendolyn Cohen, Marissa N. Dean, David G. Standaert, Timothy R. Sampson, Haydeh Payami
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Here, the authors perform large-scale high-resolution Parkinson’s disease metagenomics analyses, revealing widespread dysbiosis characterized by overabundance of pathogens, immunogens, toxicants, and curli, reduction in neuroprotective and antiinfl
Externí odkaz:
https://doaj.org/article/36926e90f9f04cf1aa145085ad06354e