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Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I

Autor: Soo-Yon Rhee, Ravindra K. Gupta, Carlo Federico Perno, John Gregson, Rawlings Datir, Derache A, R S Shafer, Deenan Pillay

Publikováno v: The Journal of Infectious Diseases

Background M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to retain modest activity agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f1bf92186401fd9660d56827e58f63
http://europepmc.org/articles/PMC7459140

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