A Customized Next-Generation Sequencing-Based Panel to Identify Novel Genetic Variants in Dementing Disorders: A Pilot Study

Autor: Raffaele Ferri, Teresa Mattina, R. S. Spada, Giuseppe Lanza, Filomena I.I. Cosentino, Mariangela Tripodi, Rita Bella, Francesco Calì, Mirella Vinci, Mariagiovanna Cantone

Publikováno v: Neural Plasticity
Neural Plasticity, Vol 2020 (2020)

Purpose. The advancements in the next-generation sequencing (NGS) techniques have allowed for rapid, efficient, and cost-time-effective genetic variant detection. However, in both clinical practice and research setting, sequencing is still often limi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abde3f874824c80a3139a15b06bce88
http://hdl.handle.net/20.500.11769/482415

'Postural first' principle when balance is challenged in elderly people

Autor: Santa Calabrese, Giuseppe Stella, Antonella Iero, Gérome C. Gauchard, Maurizio Elia, Gilles Bosser, Guido Anello, Philippe P. Perrin, Alexis Lion, Paolo Bosco, R. S. Spada

Publikováno v: International Journal of Neuroscience
International Journal of Neuroscience, Taylor & Francis, 2013, 124 (8), pp.558-566. ⟨10.3109/00207454.2013.864288⟩

International audience; Human cognitive processing limits can lead to difficulties in performing two tasks simultaneously. This study aimed to evaluate the effect of cognitive load on both simple and complex postural tasks. Postural control was evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fa0a4430f21f850d02b323c25603e4
https://doi.org/10.3109/00207454.2013.864288

miRNAs Plasma Profiles in Vascular Dementia: Biomolecular Data and Biomedical Implications

Autor: Cinzia Di Pietro, R. S. Spada, Paolo Bosco, Angelo Giuseppe Condorelli, Lucia Tamburello, Davide Barbagallo, Marina Scalia, Marco Ragusa, Mariangela Tornitore, Cristina Barbagallo, Maurizio Elia, Michele Purrello

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 10 (2016)

Vascular dementia (VaD) is a pathogenetically heterogeneous neuropsychiatric syndrome, mainly characterized by cognitive impairment. Among dementias, it is second by incidence after Alzheimer’s dementia (AD). VaD biomolecular bases have been poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02500cf4dc56a2b7801a1d75e3c965bd

Prevalence of dementia in mountainous village of Sicily

Autor: Antonino Romano, Paolo Bosco, Giuseppe Stella, Jean-Louis Guéant, Lahoucine Benamghar, R. S. Spada, Rosa Maria Guéant-Rodriguez, Guido Anello, Santa Calabrese

Publikováno v: Journal of the Neurological Sciences. 283:62-65

The progressive and rapid aging of population is the demographic characteristic in the Western countries. This rapid process of aging is causing an increasing burden on the social and health-care services. In this context, the precise knowledge of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21459d61485b5330eb81eaed827467e4
https://doi.org/10.1016/j.jns.2009.02.311

Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily

Autor: Raffaele Ferri, R. S. Spada, Rosa Maria Guéant-Rodriguez, Adrian Fajardo, Guido Anello, Antonino Romano, Jean-Louis Guéant, Paolo Bosco, Filippo Caraci

Publikováno v: Thrombosis and Haemostasis. 96:154-159

SummaryAssociation between methylenetetrahydrofolate reductase polymorphism (MTHFR 677 C>T), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7a87406ebece2723ca12741e20f474
https://doi.org/10.1160/th06-02-0082