Výsledky vyhledávání

Adsorption of methane and carbon dioxide on gas shale and pure mineral samples

Autor: Mark D. Zoback, R S Heller

Publikováno v: Journal of Unconventional Oil and Gas Resources. 8:14-24

We have measured methane and carbon dioxide adsorption isotherms at 40 °C on gas shale samples from the Barnett, Eagle Ford, Marcellus and Montney reservoirs. Carbon dioxide isotherms were included to assess its potential for preferential adsorption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4911fea02463b43ec2a3876b1ef9c5df
https://doi.org/10.1016/j.juogr.2014.06.001

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Exocrine Pancreas in Cats with Diabetes Mellitus

Autor: Melania Osto, Silvia Ferro, Eric Zini, Thomas A. Lutz, Claudia E Reusch, Laura Cavicchioli, Luigi Michele Coppola, Rossella Zanetti, R S Heller, F Lunardi, Franco Guscetti

Pancreatitis has been described in cats with diabetes mellitus, although the number of studies currently available is very limited. In addition, ketoacidosis has been hypothesized to be associated with pancreatitis in diabetic cats. The aims of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1779eb0005ecff1349e44429677b9a78
http://hdl.handle.net/11577/3166704

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Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

Autor: Allan E. Karlsen, Carsten F. Gotfredsen, Jens J. Holst, J. J. Fels, R. S. Heller, Kathrin Maedler, A. M. K. Hansen, D. N. E. Nordestgaard, Thora B. Bodvarsdottir

Publikováno v: Diabetologia. 54:1379-1387

The hormone glucagon-like peptide 1 (GLP-1) is released in response to a meal from the intestinal L-cells, where it is processed from proglucagon by the proconvertase (PC)1/3. In contrast, in the adult islets proglucagon is processed to glucagon by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6a202d2fd7dc28a0a30a47087484da
https://doi.org/10.1007/s00125-011-2080-1

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Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat

Autor: Melania Osto, Aurel Perren, Eric Zini, Thomas A. Lutz, Philippe Linscheid, Marco Franchini, Claudia E Reusch, M Bouwman, R S Heller, Mathias Ackermann, Marc Y. Donath, Franco Guscetti

Publikováno v: Zini, E.; Osto, M.; Franchini, M.; Guscetti, F.; Donath, M. Y.; Perren, Aurel; Heller, R. S.; Linscheid, P.; Bouwman, M.; Ackermann, M.; Lutz, T. A.; Reusch, C. E. (2009). Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat. Diabetologia, 52(2), pp. 336-346. Springer 10.1007/s00125-008-1201-y

Aims/hypothesis: In vitro studies point to a toxic effect of high glucose and non-esterified fatty acids on beta cells. Whether elevated levels of glucose and lipids induce beta cell loss in vivo is less clear. The domestic cat has recently been prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22d9550425c0181e655eb6564f757de
https://doi.org/10.1007/s00125-008-1201-y

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Genetic determinants of pancreatic ε-cell development

Autor: Patrick Collombat, Ole D. Madsen, Gérard Gradwohl, Marjorie Jenny, Ahmed Mansouri, R S Heller, Palle Serup, Georg Mellitzer, Catherine Tomasetto

Publikováno v: Developmental Biology. 286:217-224

Recently, the expression of the peptide hormone ghrelin was detected in alpha-cells of the islets of Langerhans as well as in epsilon-cells, a newly discovered endocrine cell type, but it remains unclear how the latter is related in lineage to the fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ad9a64fe01766b3e10189c5e39d6b5
https://doi.org/10.1016/j.ydbio.2005.06.041

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IMPAN Cells: A Pancreatic Model for Differentiation into Endocrine Cells

Autor: Tino Klein, Palle Serup, R S Heller, Ulrik Frandsen

Publikováno v: Archives of Biochemistry and Biophysics. 395:259-263

It is currently believed that pancreatic progenitor or stem cells exist in the ductal cell population and that these cells have the ability to be grown and differentiated into endocrine cells for the treatment of diabetes. In this study, we have exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adcbf4d4d1932a1df8972a5f3fc14c5
https://doi.org/10.1006/abbi.2001.2579

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Control of endodermal endocrine development by Hes-1

Autor: François Guillemot, Makoto Ishibashi, Palle Serup, R S Heller, Jan Jensen, P Galante, E E Pedersen, Ryoichiro Kageyama, Ole D. Madsen, Jacob Hald

Publikováno v: Nature Genetics. 24:36-44

Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal determination and differentiation factors, and are antagonized by the Notch pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b0f2faffc3f4ffb0196fcf00f65ff6
https://doi.org/10.1038/71657

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Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1

Autor: Joel F. Habener, Christopher Miller, Doris A. Stoffers, R S Heller

Publikováno v: Endocrinology. 140:5374-5381

Expression of the homeodomain transcription factor IDX-1 (also known as IPF-1, STF-1, and PDX-1) is required for pancreas development, because disruption of the gene in mice and humans results in pancreatic agenesis. During embryonic development the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a216d303065feffb416af35dac2dbb4
https://doi.org/10.1210/endo.140.11.7122

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