Zobrazeno 1 - 10
of 169
pro vyhledávání: '"R S, Chaganti"'
Publikováno v:
Blood. 91:603-607
The BCL6 gene encodes a POZ/Zinc-finger protein, which acts as a sequence-specific transcriptional repressor. It is expressed in B cells within the germinal centers (GC) and is required for GC formation. In approximately 40% of diffuse large cell lym
Publikováno v:
Blood. 80:2594-2599
In this series of 426 consecutively ascertained, karyotypically abnormal non-Hodgkin's lymphomas (NHLs) derived from 407 patients, a t(9;14)(p13;q32) was encountered in 7 cases; an additional case demonstrated t(9;14)(p1?3;q32). At the time of detect
Publikováno v:
Genes, chromosomescancer. 28(4)
Combining degenerate oligonucleotide-primed PCR (DOP-PCR) with comparative genomic hybridization (CGH) has made it possible to analyze genomic changes in single cells. Although DOP-PCR-CGH methodology has been reported, the reproducibility of the met
Autor:
S, Bala, H, Oliver, B, Renault, K, Montgomery, S, Dutta, P, Rao, J, Houldsworth, R, Kucherlapati, X, Wang, R S, Chaganti, V V, Murty
Publikováno v:
Genes, chromosomescancer. 28(3)
Cytogenetic and molecular analyses have shown that the chromosome band 12q22 is recurrently deleted in male germ cell tumors (GCTs), indicating the presence of a candidate tumor suppressor gene (TSG) in this region. To identify the TSG, we mapped the
Autor:
S P, Schantz, Q, Huang, K, Shah, V V, Murty, T C, Hsu, G, Yu, P E, Andersen, A G, Huvos, R S, Chaganti
Publikováno v:
Carcinogenesis. 21(6)
The interaction between environmental exposures and host susceptibility may lead to specific mutational events within head and neck squamous cell carcinoma (HNSCC). Furthermore, this interplay may determine not only the probability of cancer developm
Autor:
R S, Chaganti, J, Houldsworth
Publikováno v:
Cancer research. 60(6)
Adult human male germ cell tumors (GCTs) provide a unique opportunity to study the generation of a transformed pluripotential cell from a totipotential GC in lineage differentiation and on the path to gametogenesis. The pluripotentiality of the tumor
Autor:
S B, Brown, T T, Brierley, N, Palanisamy, I B, Salusky, W, Goodman, M L, Brandi, T B, Drüeke, E, Sarfati, P, Ureña, R S, Chaganti, J W, Pike, A, Arnold
Publikováno v:
The Journal of clinical endocrinology and metabolism. 85(2)
Most chronic renal failure patients with severe refractory hyperparathyroidism harbor at least one monoclonal parathyroid tumor, but the specific acquired genetic defects that confer this clonal selective advantage remain poorly understood. Somatic i
Autor:
J C, Cigudosa, N Z, Parsa, D C, Louie, D A, Filippa, S C, Jhanwar, B, Johansson, F, Mitelman, R S, Chaganti
Publikováno v:
Genes, chromosomescancer. 25(2)
Cytogenetic analysis was performed on 363 biopsy specimens with histologically confirmed diffuse large B-cell lymphoma (DLBCL), consecutively ascertained at the Memorial Sloan-Kettering Cancer Center, New York, between 1984 and 1994. Among 248 sample
Publikováno v:
Genes, chromosomescancer. 24(4)
The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. The PTEN gene product is a dual-specificity phosphatase with putative tumor suppressor function. Deletions and r
Autor:
S R, Chaganti, P H, Rao, W, Chen, V, Dyomin, S C, Jhanwar, N Z, Parsa, R, Dalla-Favera, R S, Chaganti
Publikováno v:
Genes, chromosomescancer. 23(4)
Chromosomal band 3q27 frequently engages in translocations with a number of sites within the genome, including those containing IG and other genes, during the development of B-cell lymphoma. The BCL6 gene, mapped at 3q27, is deregulated in these tran