Comatulins A–E, Taurine-Conjugated Anthraquinones from the Australian Crinoid Comatula rotalaria

Autor: R. S. Addison, Jonathan M. White, Merrick Ekins, Sasha Hayes, Kah Yean Lum, Rohan A. Davis, James Anthony St John, Aya C Taki, Ian Tietjen, Robin B. Gasser

Publikováno v: Journal of Natural Products. 83:1971-1979

Chemical investigations of two specimens of the Australian crinoid Comatula rotalaria afforded five new taurine-conjugated anthraquinones, comatulins A–E (1–5), together with 11 known marine natura...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b797a472cc446896ebf6e3c828b38a48
https://doi.org/10.1021/acs.jnatprod.0c00267

Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

Autor: Sasha Hayes, Bill C.H. Chang, Andreas Hofmann, Tao Wang, H. M. P. Dilrukshi Herath, Rohan A. Davis, Jose F. Garcia-Bustos, Abdul Jabbar, R. S. Addison, Sarah Preston, Anson V. Koehler, Robin B. Gasser, Topul Rali

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 72-79 (2019)
International Journal for Parasitology: Drugs and Drug Resistance

Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e27caf76536c9b8afaf19e050c58e
http://www.sciencedirect.com/science/article/pii/S2211320718301581

Midazolam Metabolism: Implications for Individualised Dosing?

Autor: Jeffrey Lipman, Carole L. Foot, Jason A. Roberts, R. S. Addison, Mark G. Coulthard

Publikováno v: Scopus-Elsevier

Aim: To compare the clearance of midazolam and its metabolites in critically ill paediatric and adult patients. Method: A prospective study conducted in paediatric and adult intensive care units. Patients over 2 years of age receiving midazolam for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa463f51fe5fbe4d5b9244e216450a
https://doi.org/10.1002/j.2055-2335.2009.tb00452.x

Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations

Autor: R. S. Addison, A. Matthias, Kenneth Watson, Kerry Bone, R. P. Lehmann, Linda L. Agnew

Publikováno v: Phytomedicine. 14:587-590

The relative oral bioavailability of alkylamides from two different Echinacea dosage forms (liquid and tablet) were compared in a small two-way crossover study in humans (n=3). The liquid preparation investigated contained a mixture of Echinacea purp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762eb75e151663c83134ab788366fe69
https://doi.org/10.1016/j.phymed.2006.12.021

Synthesis, Biological Activity, and Preliminary Pharmacokinetic Evaluation of Analogues of a Phosphosulfomannan Angiogenesis Inhibitor (PI-88)

Autor: Tomislav Karoli, Ligong Liu, Jon K. Fairweather, R. S. Addison, Cai Ping Li, Edward Hammond, Kicki Bergefall, Edward Trybala, Vito Ferro, Siska Cochran

Publikováno v: Journal of Medicinal Chemistry. 48:8229-8236

The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that is currently undergoing clinical evaluation in cancer patients. As well as its anticancer properties, 1 displays a number of other interesting biological activitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b995c34eb6cd5fbf5b3a24d6ff9d0c
https://doi.org/10.1021/jm050618p