Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R Ryan Meyerhoff"'
Autor:
M Anthony Moody, Ruijun Zhang, Emmanuel B Walter, Christopher W Woods, Geoffrey S Ginsburg, Micah T McClain, Thomas N Denny, Xi Chen, Supriya Munshaw, Dawn J Marshall, John F Whitesides, Mark S Drinker, Joshua D Amos, Thaddeus C Gurley, Joshua A Eudailey, Andrew Foulger, Katherine R DeRosa, Robert Parks, R Ryan Meyerhoff, Jae-Sung Yu, Daniel M Kozink, Brice E Barefoot, Elizabeth A Ramsburg, Surender Khurana, Hana Golding, Nathan A Vandergrift, S Munir Alam, Georgia D Tomaras, Thomas B Kepler, Garnett Kelsoe, Hua-Xin Liao, Barton F Haynes
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25797 (2011)
During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal triva
Externí odkaz:
https://doaj.org/article/4d8cdd55621e469d9b7ec0a026be6367
Autor:
Daniela Fera, Matthew S. Lee, Kevin Wiehe, R. Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, William E. Walkowicz, Therese Ton, Jeffrey O. Zhou, Samuel Danishefsky, Barton F. Haynes, Stephen C. Harrison
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The V3 region of HIV Env elicits broadly neutralizing antibodies (bnAbs) in patients and represents a potential vaccine antigen. Here, Fera et al. show that the structure of a synthetic V3-glycopeptide closely resembles the conformation in intact HIV
Externí odkaz:
https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
Autor:
Kevin O. Saunders, Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R. Ryan Meyerhoff, Robert Parks, William E. Walkowicz, Baptiste Aussedat, Nelson R. Wu, Fangping Cai, Yusuf Vohra, Peter K. Park, Amanda Eaton, Eden P. Go, Laura L. Sutherland, Richard M. Scearce, Dan H. Barouch, Ruijun Zhang, Tarra Von Holle, R. Glenn Overman, Kara Anasti, Rogier W. Sanders, M. Anthony Moody, Thomas B. Kepler, Bette Korber, Heather Desaire, Sampa Santra, Norman L. Letvin, Gary J. Nabel, David C. Montefiori, Georgia D. Tomaras, Hua-Xin Liao, S. Munir Alam, Samuel J. Danishefsky, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://doaj.org/article/f020d40e9877461f93e8d9d15c7fa9e4
Autor:
Naomi Bronkema, S. Munir Alam, M. Anthony Moody, David C. Montefiori, Wilton B. Williams, Kartik Manne, Andrew Foulger, Victoria Stalls, Matthew S. Lee, Thomas B. Kepler, Daniela Fera, John R. Perfect, Hui Li, Mario J. Borgnia, Celia C. LaBranche, Allen L. Hsu, Michael S. Seaman, Robert Parks, Joseph R. Francica, Kevin Wiehe, Mattia Bonsignori, Peter D. Kwong, Katarzyna Janowska, Ye Zhou, Robert A. Seder, Geoffrey M. Lynn, Priyamvada Acharya, R. Ryan Meyerhoff, Robert J. Edwards, Rory Henderson, Nathan I. Nicely, Richard Laga, Kevin O. Saunders, William E. Walkowicz, Garnett Kelsoe, Katayoun Mansouri, Alberto Bartesaghi, Sampa Santra, Guillaume Stewart-Jones, George M. Shaw, Barton F. Haynes, Todd Bradley, Baptiste Aussedat
SummaryThe HIV-1 envelope (Env) is comprised by mass of over 50% glycans. A goal of HIV-1 vaccine development is the induction of Env glycan-reactive broadly neutralizing antibodies (bnAbs). The 2G12 bnAb recognizes an Env glycan cluster using a uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d7a6461325995b4d86f3c77c84df10
https://doi.org/10.1101/2020.06.30.178921
https://doi.org/10.1101/2020.06.30.178921
Autor:
Victoria Stalls, Gregory D. Sempowski, Katarzyna Janowska, Robert Parks, Rory Henderson, Margaret Deyton, Thomas H. Oguin, R. Ryan Meyerhoff, Wilton B. Williams, Katayoun Mansouri, Kartik Manne, Jordan Sprenz, Robert J. Edwards, Megan Kopp, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes
Publikováno v:
bioRxiv
SummaryThe COVID-19 pandemic caused by SARS-CoV-2 has escalated into a global crisis. The spike (S) protein that mediates cell entry and membrane fusion is the current focus of vaccine and therapeutic antibody development efforts. The S protein, like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f640dfed198231724eb1e9dfe17d2
https://europepmc.org/articles/PMC7337383/
https://europepmc.org/articles/PMC7337383/
Autor:
William E. Walkowicz, Samuel J. Danishefsky, Barton F. Haynes, Baptiste Aussedat, Mattia Bonsignori, Daniela Fera, Jeffrey O. Zhou, Stephen C. Harrison, Alessandro Piai, Matthew S. Lee, R. Ryan Meyerhoff, Kevin Wiehe, Therese Ton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591802380d054e8a134dc37e8b49f997
https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
Autor:
Hanghang Wang, Chi-Fu Jeffrey Yang, Nicholas R. Mayne, Sai Yendamuri, Keith W. VanDusen, Sameer A. Hirji, R. Ryan Meyerhoff, Todd L. Demmy, Mark F. Berry, Thomas A. D'Amico, Robert J. McKenna, Athar Battoo
Publikováno v:
J Thorac Cardiovasc Surg
OBJECTIVE: The objective of this study was to evaluate the impact of the video-assisted thoracoscopic (VATS) approach on the outcomes of patients who underwent pneumonectomy. METHODS: The effect of the surgical approach on perioperative complications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3981f95d9e568e590755a5283313cd
https://europepmc.org/articles/PMC7028319/
https://europepmc.org/articles/PMC7028319/
Autor:
Katarzyna Janowska, Guillaume Stewart-Jones, Ye Zhou, Bhavna Hora, Naomi Bronkema, Tyler Evangelous, Alberto Bartesaghi, John R. Perfect, Hui Li, Robert A. Seder, Michael S. Seaman, Celia C. LaBranche, A. Yousef Abuahmad, Jordan Sprenz, Joseph R. Francica, M. Anthony Moody, Baptiste Aussedat, S. Munir Alam, Garnett Kelsoe, Sampa Santra, Barton F. Haynes, Richard Laga, Priyamvada Acharya, Katayoun Mansouri, Daniela Fera, Victoria Stalls, Nathan I. Nicely, Margaret Deyton, Allen L. Hsu, Madison Berry, George M. Shaw, Megan Kopp, William E. Walkowicz, David C. Montefiori, Gregory D. Sempowski, Matthew S. Lee, Sophie M. C. Gobeil, Mario J. Borgnia, Todd Bradley, Thomas H. Oguin, R. Ryan Meyerhoff, Robert Parks, Kevin Wiehe, Mattia Bonsignori, Peter D. Kwong, Kartik Manne, Geoffrey M. Lynn, Rory Henderson, Robert J. Edwards, Wilton B. Williams, Andrew Foulger, Kevin O. Saunders
Publikováno v:
Cell
Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a6c55602fcef3c8867380821339b62
http://europepmc.org/articles/PMC8135257
http://europepmc.org/articles/PMC8135257
Autor:
Paul J. Speicher, Brandon W. Yan, Matthew G. Hartwig, Chi-Fu Jeffrey Yang, David H. Harpole, Thomas A. D'Amico, Shakir M. Saud, R. Ryan Meyerhoff, Mark F. Berry, Brian C. Gulack
Publikováno v:
Clinical Lung Cancer. 17:419-426
Although malignant pleural mesothelioma (MPM) is generally a disease associated with more advanced age, the association of age, treatment, and outcomes has not been well-characterized. We evaluated the impact of age on outcomes in patients with MPM t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6257b455de1d6c19919a10bd5e0250e
https://doi.org/10.1016/j.cllc.2016.03.002
https://doi.org/10.1016/j.cllc.2016.03.002
Autor:
Kevin, Wiehe, Todd, Bradley, R Ryan, Meyerhoff, Connor, Hart, Wilton B, Williams, David, Easterhoff, William J, Faison, Thomas B, Kepler, Kevin O, Saunders, S Munir, Alam, Mattia, Bonsignori, Barton F, Haynes
Publikováno v:
Cell hostmicrobe. 23(6)
HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent AID activity, while improba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9337461b16ac5b361c4d2ec7eb8509d4
https://pubmed.ncbi.nlm.nih.gov/29861171
https://pubmed.ncbi.nlm.nih.gov/29861171