Inhibition of 5-lipoxygenase blocks IL-1 beta-induced vascular adhesion molecule-1 gene expression in human endothelial cells

Autor: S Lee, K A Felts, G C Parry, L M Armacost, R R Cobb

Publikováno v: The Journal of Immunology. 158:3401-3407

Inflammation is characterized by the recruitment of leukocytes and their subsequent migration from the vasculature into the tissue, where they often cause severe damage. Endothelial cells play a major role in this cascade by expressing cell surface a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82d3b9744925d4d7170554c608fd81e8
https://doi.org/10.4049/jimmunol.158.7.3401

D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells

Autor: R R, Cobb, K A, Felts, G C, Parry, N, Mackman

Publikováno v: Molecular pharmacology. 49(6)

At sites of inflammation, endothelial cells play a major role in defining the types of leukocytes that are recruited to a specific area. This is accomplished, at least in part, through the cytokine induction of cell surface adhesion molecules, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77e7647f38e43653a17e024b6a9d3809
https://pubmed.ncbi.nlm.nih.gov/8649360

A unique alpha chain in hemoglobin of 'Skive' Danish Mus musculus

Autor: Raymond A. Popp, J. B. Whitney, R. R. Cobb, K. A. Comer

Publikováno v: Biochemical genetics. 26(1-2)

The primary structures of the alpha chains in hemoglobins from three stocks of mice with the Hbaw2, Hbaw3, and Hbaw4 haplotypes were determined to establish whether the tentative alpha-chain assignments based on the results of isoelectric focusing pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac4e4786c75a0ed4ac417e509b4fa0c
https://pubmed.ncbi.nlm.nih.gov/3377753

Classical and molecular genetic analyses of his-3 mutants of Neurospora crassa. II. Southern blot analyses and molecular mechanisms of mutagenicity

Autor: J S, Dubins, L K, Overton, R R, Cobb, F J, de Serres

Publikováno v: Mutation research. 215(1)

Previous studies (Overton et al., Mutation Res., 1989) on specific revertibility of 81 his-3 mutants have shown a correlation between complementation pattern and presumed genetic alteration similar to that shown by ad-3B mutants. In the present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b78f1504eaa228abdf178b4ff62431d2
https://pubmed.ncbi.nlm.nih.gov/2530448

Experience from the selection and nutritional preparation for Expedition ICE MAIDEN: the first successful all-female unassisted Antarctic traverse.

Autor: Taylor N; Academic Department of General Practice, Defence Medical Services Research and Clinical Innovation, Birmingham, UK., Gifford RM; University/ British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK r.gifford@ed.ac.uk.; Academic Department of Military Medicine, Defence Medical Services Research and Clinical Innovation, Birmingham, UK., Cobb R; PND Consulting, Birmingham, UK., Wardle SL; Army Personnel Research Capability, Army Headquarters, Andover, UK., Jones S; Antarctic Logistics and Expeditions, Salt Lake City, Utah, USA., Blackadder-Weinstein J; Academic Department of General Practice, Defence Medical Services Research and Clinical Innovation, Birmingham, UK., Hattersley J; Human Metabolic Research Unit, Universities of Coventry and Warwickshire NHS Trust and University of Warwick, Warwick, UK., Wilson A; Human Metabolic Research Unit, Universities of Coventry and Warwickshire NHS Trust and University of Warwick, Warwick, UK., Imray C; Human Metabolic Research Unit, Universities of Coventry and Warwickshire NHS Trust and University of Warwick, Warwick, UK., Greeves JP; Army Personnel Research Capability, Army Headquarters, Andover, UK., Reynolds R; University/ British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Woods DR; Academic Department of Military Medicine, Defence Medical Services Research and Clinical Innovation, Birmingham, UK.; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UK.

Publikováno v: BMJ military health [BMJ Mil Health] 2021 Feb; Vol. 167 (1), pp. 27-32. Date of Electronic Publication: 2019 May 15.