Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R R Beerli"'
Autor:
C. Uermösi, Monika Bauer, Martin F. Bachmann, Gabriela Senti, R. R. Beerli, Thomas M. Kündig, Philippe Saudan, Vania Manolova, Franziska Zabel
Background: Allergen-specific IgGs are known to inhibit IgE-mediated mast cell degranulation by two mechanisms, allergen-neutralization and engagement of the inhibitory FcγRIIB recruiting the phosphatase SHIP-1. Here we unravel an additional mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e36e6db2a06b1e9a7dfaaf79a58af49
https://doi.org/10.5167/uzh-91804
https://doi.org/10.5167/uzh-91804
Publikováno v:
Molecular and Cellular Biology. 15:1182-1191
ErbB-2 becomes rapidly phosphorylated and activated following treatment of many cell lines with epidermal growth factor (EGF) or Neu differentiation factor (NDF). However, these factors do not directly bind ErbB-2, and its activation is likely to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614e92883a95893a1f19cc56c9896d11
https://doi.org/10.1128/mcb.15.3.1182
https://doi.org/10.1128/mcb.15.3.1182
Publikováno v:
Journal of Biological Chemistry. 269:23931-23936
We report a novel approach for specific in vivo inactivation of the ErbB-2 receptor tyrosine kinase and suppression of ErbB-2-induced transformation. Genes encoding single chain antibodies that specifically bind to the extracellular domain of human E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c4911777a1c86f2a35e610fa0354eb
https://doi.org/10.1016/s0021-9258(19)51027-4
https://doi.org/10.1016/s0021-9258(19)51027-4
Publikováno v:
Cancer research. 57(17)
Neu differentiation factor (NDF), a member of the epidermal growth factor (EGF)-related peptide family, activates ErbB2 via heterodimerization with the NDF receptors ErbB3 and ErbB4. In a similar fashion, EGF receptor (EGFR) agonists induce heterodim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5789435c521ab44130bc7b0f592707cf
https://pubmed.ncbi.nlm.nih.gov/9288791
https://pubmed.ncbi.nlm.nih.gov/9288791
Publikováno v:
EGF Receptor in Tumor Growth and Progression ISBN: 9783662033937
More than a decade ago, cytotoxic agents termed immunotoxins were designed by coupling bacterial or plant toxins to monoclonal antibodies specific for molecules on the surface of tumor cells. Advances in various fields of investigation have led to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f66ef2400f01d93965cf42c84f6aa6
https://doi.org/10.1007/978-3-662-03391-3_11
https://doi.org/10.1007/978-3-662-03391-3_11
Publikováno v:
Oncogene. 13(2)
A gene encoding a single-chain antibody (scFv) which specifically binds the epidermal growth factor receptor (EGFR) has been constructed from hybridoma cells producing the R1 monoclonal antibody. The gene, designated scFv-R1R, was introduced into EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1bdfb14a00d5c249fd250d1401d5207
https://pubmed.ncbi.nlm.nih.gov/8710366
https://pubmed.ncbi.nlm.nih.gov/8710366
Autor:
S S, Bacus, Y, Yarden, M, Oren, D M, Chin, L, Lyass, C R, Zelnick, A, Kazarov, W, Toyofuku, J, Gray-Bablin, R R, Beerli, N E, Hynes, M, Nikiforov, R, Haffner, A, Gudkov, K, Keyomarsi
Publikováno v:
Oncogene. 12(12)
Previously we reported that neu differentiation factor (NDF)/heregulin (HRG) elevates tyrosine phosphorylation of its receptors erbB-3, erbB-4, and erbB-2 (through heterodimer formation). We also showed that both NDF/HRG and antibodies to erbB-2 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79408c1355449c1417d1b353343732e7
https://pubmed.ncbi.nlm.nih.gov/8700512
https://pubmed.ncbi.nlm.nih.gov/8700512
Autor:
N E Hynes, Devarajan Karunagaran, E Tzahar, Yosef Yarden, Rony Seger, D Graus-Porta, R R Beerli, B J Ratzkin, Xiaomei Chen
Overexpression of the erbB-2 gene contributes to aggressive behavior of various human adenocarcinomas, including breast cancer, through an unknown molecular mechanism. The erbB-2-encoded protein is a member of the ErbB family of growth factor recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1b07a8ec8f4da540474717a25be349
https://europepmc.org/articles/PMC449940/
https://europepmc.org/articles/PMC449940/
Neu differentiation factor (NDF)-induced signaling involves the activation of members of the ErbB family of receptor tyrosine kinases. Although ectopic expression of recombinant ErbB receptors has yielded valuable insight into their signaling propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5664ab195a13bc4408afa3ed58e1ae2a
https://europepmc.org/articles/PMC230902/
https://europepmc.org/articles/PMC230902/
Publikováno v:
Biochemical and biophysical research communications. 204(2)
A gene encoding a single-chain antibody which specifically binds the human epidermal growth factor (EGF) receptor has been constructed and expressed intracellularly. The single-chain antibody is derived from monoclonal antibody 225 which competes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb3a3b023c97ec35dee50c3c287dc07
https://pubmed.ncbi.nlm.nih.gov/7980527
https://pubmed.ncbi.nlm.nih.gov/7980527