Zobrazeno 1 - 10
of 651
pro vyhledávání: '"R R, Tidwell"'
Autor:
Donald A. Patrick, R R Tidwell, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira, C. F. Da Silva, P. B. Da Silva, Kelly Cristina Demarque, Svetlana M. Bakunova, Constança Britto, Stanislav A. Bakunov, T. O. Fulco, Julianna Siciliano de Araújo, F. H. Guedes-da-Silva, Gilkethyla Mexlayne de Oliveira, D. G. J. Batista, M. B. Meuser
Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, including Trypanosoma cruzi , which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9931d7933fdd07aea27acf8c429ef9b4
https://europepmc.org/articles/PMC4808220/
https://europepmc.org/articles/PMC4808220/
Autor:
Joseph Mathu Ndung'u, R R Tidwell, J. M. Ngotho, John K. Thuita, R. E. Mdachi, Grace Murilla, Reto Brun, James Edwin Hall, John Kagira
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:953-957
Owing to the lack of oral drugs for human African trypanosomiasis, patients have to be hospitalized for 10 to 30 days to facilitate treatment with parenterally administered medicines. The efficacy of a novel orally administered prodrug, 2,5-bis(4-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98976b50cd1a192ea2380ee56ee22ce
https://doi.org/10.1128/aac.00831-08
https://doi.org/10.1128/aac.00831-08
Publikováno v:
British Journal of Pharmacology. 152:1155-1171
This review discusses the challenges of chemotherapy for human African trypanosomiasis (HAT). The few drugs registered for use against the disease are unsatisfactory for a number of reasons. HAT has two stages. In stage 1 the parasites proliferate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d66aecdf41518f9cb0591bcb7b70ed
https://doi.org/10.1038/sj.bjp.0707354
https://doi.org/10.1038/sj.bjp.0707354
Publikováno v:
Xenobiotica. 35:211-226
A new aza-analogue of furamidine, 6-[5-(4-amidinophenyl)-furan-2-yl]nicotinamidine (DB820), has potent in vitro antitrypanosomal activity; however, it suffers from poor oral activity because of its positively charged amidine groups. The dimethoxyamid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9fa8fe6e5272e974d97390f8f6bc8
https://doi.org/10.1080/00498250500087671
https://doi.org/10.1080/00498250500087671
Autor:
Brenden C. Bender, David W. Boykin, F. A. Tanious, W D Wilson, J. E. Hall, Donald R. McCurdy, Iris Francesconi, R R Tidwell
Publikováno v:
Journal of Medicinal Chemistry. 42:2260-2265
Dicationic 2,4-bis(4-amidinophenyl)furans 5-10 and 2, 4-bis(4-amidinophenyl)-3,5-dimethylfurans 14 and 15 have been synthesized. Thermal melting studies revealed high binding affinity of the compounds to poly(dA-dT) and to the duplex oligomer d(CGCGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bde90c5fc136d6903e08c73c4c6d86
https://doi.org/10.1021/jm990071c
https://doi.org/10.1021/jm990071c
Autor:
J. E. Hall, R R Tidwell, Donald R. McCurdy, D. W. Boykin, W. D. Wilson, Miroslav Bajić, G. Xiao, Arvind Kumar, Brenden C. Bender
Publikováno v:
European Journal of Medicinal Chemistry. 32:965-972
Summary Synthesis of 2,4-bis-(4-amidinophenyl)-6-methylpyrimidine 5 , 2,4-bis-[(4-imidazolin-2-yl)phenyl]-6-methylpyrimidine 6 , 2,4-bis[(4- N-i -propylamidino)phenyl]-6-methylpyrimidine 7, and 2,4-bis[(4- N -isopentylamidino)phenyl]-6-methylpyrimidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce1c39e09cf4ba631ca3b04d854db80
https://doi.org/10.1016/s0223-5234(97)89640-7
https://doi.org/10.1016/s0223-5234(97)89640-7
Publikováno v:
Biochemistry. 36:15315-15325
The effect of opportunistic infections (OI) on immune-compromised populations has been known for decades, but the recent AIDS epidemic has sparked renewed interest in the development of new anti-OI agents. The mechanism of action of a series of catio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef75009d4b9738df927f8c3b3160580
https://doi.org/10.1021/bi971599r
https://doi.org/10.1021/bi971599r
Publikováno v:
Journal of Medicinal Chemistry. 39:1452-1462
Considerable evidence now indicates that DNA is the receptor site for dicationic benzimidazole anti-opportunistic infections agents (Bell, C. A. ; Dykstra, C. C. ; Naiman, N. A. I. ; Cory, M. ; Fairley, T. A. ; Tidwell, R. R. Antimicrob. Agents Chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47ff9eef4b969a6640aa43dda623a82
https://doi.org/10.1021/jm9507946
https://doi.org/10.1021/jm9507946
Autor:
Jarosław Spychała, Arvind Kumar, Lombardy Rj, Susan Jones, Christine C. Dykstra, W. D. Wilson, Zhou M, R R Tidwell, David W. Boykin, James Edwin Hall
Publikováno v:
Journal of Medicinal Chemistry. 38:912-916
Seven dicationic 2,5-diarylfurans have been synthesized, and their interactions with poly(dA-dT) and the duplex oligomer d(CGCCAATTCGCG)2 were evaluated by Tm measurements. The inhibition of topoisomerase II isolated from Giardia lamblia, the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177d83b88e5abb22d2a78c56bdb0dc91
https://doi.org/10.1021/jm00006a009
https://doi.org/10.1021/jm00006a009
Autor:
R, Varkevisser, M J C, Houtman, T, Linder, K C G, de Git, H D M, Beekman, R R, Tidwell, A P, Ijzerman, A, Stary-Weinzinger, M A, Vos, M A G, van der Heyden
Publikováno v:
British journal of pharmacology. 169(6)
Drug interference with normal hERG protein trafficking substantially reduces the channel density in the plasma membrane and thereby poses an arrhythmic threat. The chemical substructures important for hERG trafficking inhibition were investigated usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b35291a42e866997660978050c336f53
https://pubmed.ncbi.nlm.nih.gov/23586323
https://pubmed.ncbi.nlm.nih.gov/23586323